Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Aoi Uchida"'
Autor:
Ryo Ito, Shiyu Xie, Myagmar Tumenjargal, Yuto Sugahara, Chaoran Yang, Hiroki Takahashi, Makoto Arai, Shin-Ichi Inoue, Aoi Uchida, Kenji Nakano, Hyunmi Choi, Ge Yang, Yanan Zhao, Rei Yamaguchi, Hitomi Jin, Hina Sagae, Youichiro Wada, Toshiya Tanaka, Hiroshi Kimura, Tatsuhiko Kodama, Hiroyuki Aburatani, Kazuhisa Takeda, Takeshi Inagaki, Timothy F. Osborne, Takeshi Yoneshiro, Yoshihiro Matsumura, Juro Sakai
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109398- (2024)
Summary: Mitochondria play a vital role in non-shivering thermogenesis in both brown and subcutaneous white adipose tissues (BAT and scWAT, respectively). However, specific regulatory mechanisms driving mitochondrial function in these tissues have be
Externí odkaz:
https://doaj.org/article/04a6729f65d1452297c0ef6f43b6e818
Autor:
Hiroki Takahashi, Ge Yang, Takeshi Yoneshiro, Yohei Abe, Ryo Ito, Chaoran Yang, Junna Nakazono, Mayumi Okamoto-Katsuyama, Aoi Uchida, Makoto Arai, Hitomi Jin, Hyunmi Choi, Myagmar Tumenjargal, Shiyu Xie, Ji Zhang, Hina Sagae, Yanan Zhao, Rei Yamaguchi, Yu Nomura, Yuichi Shimizu, Kaito Yamada, Satoshi Yasuda, Hiroshi Kimura, Toshiya Tanaka, Youichiro Wada, Tatsuhiko Kodama, Hiroyuki Aburatani, Min-Sheng Zhu, Takeshi Inagaki, Timothy F. Osborne, Takeshi Kawamura, Yasushi Ishihama, Yoshihiro Matsumura, Juro Sakai
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
How β-AR signaling coordinates epigenetic and transcriptional pathways is unknown. Here the authors show that cold-induced β-AR signaling negatively regulates MYPT1-PP1β phosphatase activity to orchestrate both pathways for beige adipogenesis.
Externí odkaz:
https://doaj.org/article/208e13262a3c409a916118bc6968d38e
Autor:
Yoshihiro Matsumura, Ryo Ito, Ayumu Yajima, Rei Yamaguchi, Toshiya Tanaka, Takeshi Kawamura, Kenta Magoori, Yohei Abe, Aoi Uchida, Takeshi Yoneshiro, Hiroyuki Hirakawa, Ji Zhang, Makoto Arai, Chaoran Yang, Ge Yang, Hiroki Takahashi, Hitomi Fujihashi, Ryo Nakaki, Shogo Yamamoto, Satoshi Ota, Shuichi Tsutsumi, Shin-ichi Inoue, Hiroshi Kimura, Youichiro Wada, Tatsuhiko Kodama, Takeshi Inagaki, Timothy F. Osborne, Hiroyuki Aburatani, Koichi Node, Juro Sakai
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
How enhancers transition from a hypoacetylated primed state to a hyperacetylated-active state in response to differentiation stimuli is incompletely understood. Here the authors show that SETD5 forms a complex with NCoR-HDAC3 co-repressor to prevent
Externí odkaz:
https://doaj.org/article/2640437aeaa849649cfb58cee545c8e6
Autor:
Yohei Abe, Yosuke Fujiwara, Hiroki Takahashi, Yoshihiro Matsumura, Tomonobu Sawada, Shuying Jiang, Ryo Nakaki, Aoi Uchida, Noriko Nagao, Makoto Naito, Shingo Kajimura, Hiroshi Kimura, Timothy F. Osborne, Hiroyuki Aburatani, Tatsuhiko Kodama, Takeshi Inagaki, Juro Sakai
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
JMJD1A is essential for thermogenic gene induction in brown adipose tissue. Here the authors show that white adipose tissue beige-ing requires both β-adrenergic-dependent phosphorylation of S265 and demethylation activity of JMJD1A while brown adipo
Externí odkaz:
https://doaj.org/article/8e2974ccca4346e5a092dfe5a533855a
Autor:
Hiroki Takahashi, Ge Yang, Takeshi Yoneshiro, Yohei Abe, Ryo Ito, Chaoran Yang, Junna Nakazono, Aoi Uchida, Makoto Arai, Hitomi Jin, Rei Yamaguchi, Yu Nomura, Kaito Yamada, Satoshi Yasuda, Hiroshi Kimura, Toshiya Tanaka, Youichiro Wada, Tatsuhiko Kodama, Hiroyuki Aburatani, Min-Sheng Zhu, Takeshi Inagaki, Timothy Osborne, Takeshi Kawamura, Yasushi Ishihama, Yoshihiro Matsumura, Juro Sakai
Protein kinase A promotes beige adipogenesis downstream from β-adrenergic receptor signaling by phosphorylating proteins, including histone H3 lysine 9 (H3K9) demethylase JMJD1A. To ensure homeostasis, this process needs to be reversible however, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d91ecb21d749c7b0d0942d8e46ae1ae2
https://doi.org/10.21203/rs.3.rs-1495671/v1
https://doi.org/10.21203/rs.3.rs-1495671/v1
Autor:
Toshiya Tanaka, Aoi Uchida, Takeshi Inagaki, Shogo Yamamoto, Tatsuhiko Kodama, Yoshihiro Matsumura, Ryo Ito, Yohei Abe, Youichiro Wada, Ryo Nakaki, Hiroyuki Aburatani, Koichi Node, Shuichi Tsutsumi, Rei Yamaguchi, Makoto Arai, Hitomi Fujihashi, Hiroki Takahashi, Ji Zhang, Kenta Magoori, Hiroyuki Hirakawa, Takeshi Kawamura, Hiroshi Kimura, Shin Ichi Inoue, Juro Sakai, Chaoran Yang, Ayumu Yajima, Timothy F. Osborne, Ge Yang, Satoshi Ota, Takeshi Yoneshiro
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
Enhancer activation is essential for cell-type specific gene expression during cellular differentiation, however, how enhancers transition from a hypoacetylated “primed” state to a hyperacetylated-active state is incompletely understood. Here, we
Autor:
Tatsuhiko Kodama, Hideo Harigae, Timothy F. Osborne, Toshiya Tanaka, Aoi Uchida, Takao Hamakubo, Hiroto Ohguchi, Insook Kim, Takeshi Sasaki, Frank J. Gonzalez, Kenta Magoori, Masashi Okamura, Iori Sakakibara, Hiromi Kudo, Juro Sakai, Kenji Daigo
Publikováno v:
Molecular and Cellular Biology. 28:3917-3931
Type 1 iodothyronine deiodinase (Dio1), a selenoenzyme catalyzing the bioactivation of thyroid hormone, is highly expressed in the liver. Dio1 mRNA and enzyme activity levels are markedly reduced in the livers of hepatocyte nuclear factor 4alpha (HNF
Autor:
Masashi Okamura, Tatsuhiko Kodama, Yosuke Inagaki, Juro Sakai, Tokuo T. Yamamoto, Toshiya Tanaka, Aoi Uchida, Yasuyo Urashima, Yukio Ikeda, Haruhisa Iguchi
Publikováno v:
Journal of Biological Chemistry. 282:19052-19061
Sex-determining region Y-box (SOX) 6 negatively regulates glucose-stimulated insulin secretion from beta-cells and is a down-regulated transcription factor in the pancreatic islet cells of hyperinsulinemic obese mice. To determine the contribution of
Publikováno v:
Neuroscience Research. 54:288-294
Zaltoprofen, a preferential COX-2 inhibitor, exhibited a potent inhibitory action on the nociceptive responses induced by a retrograde infusion of bradykinin into the right common carotid artery in rats. However, other COX-2 preferential inhibitors s
Autor:
Ryoichi X. Ioka, Shuying Jiang, Tatsuhiko Kodama, Timothy F. Osborne, Riuko Ohashi, Takashi Maejima, Yukio Ikeda, Juro Sakai, Haruhisa Iguchi, Koichi Sumi, Tokuo T. Yamamoto, Yasuyo Urashima, Masashi Yanagisawa, Hiroto Ohguchi, Noriaki Kojima, Masashi Okamura, Kenta Magoori, Satoshi Iwasaki, Shinobu Takayasu, Makoto Naito, Toshiya Tanaka, Aoi Uchida, Go Hasegawa
Publikováno v:
Journal of Biological Chemistry. 280:37669-37680
In obesity-related insulin resistance, pancreatic islets compensate for insulin resistance by increasing secretory capacity. Here, we report the identification of sex-determining region Y-box 6 (SOX6), a member of the high mobility group box superfam