Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Aoi Akitsu"'
Autor:
Aoi Akitsu, Yoichiro Iwakura
Publikováno v:
Bio-Protocol, Vol 6, Iss 17 (2016)
Infiltration of leukocytes into joints is one of the main features of autoimmune inflammatory arthritis. Here, we describe the protocol for isolation of joint-infiltrating cells in mice. This protocol is useful to analyze cell surface antigens and in
Externí odkaz:
https://doaj.org/article/709c352a71624516868b78eaa3656cf6
Autor:
Jonathan S. Duke-Cohan, Aoi Akitsu, Robert J. Mallis, Cameron M. Messier, Patrick H. Lizotte, Jon C. Aster, Wonmuk Hwang, Matthew J. Lang, Ellis L. Reinherz
Publikováno v:
Nature
Programming T lymphocytes to distinguish self from non-self is a vital, multi-step process arising in the thymus(1–4). Signalling through the pre-T cell receptor (preTCR), a CD3-associated heterodimer comprising an invariant pTα chain and a clone-
Autor:
David A. Barbie, Matthew G. Oser, Ellis L. Reinherz, Scott Rodig, Robin Edwards, Evisa Gjini, Pasi A. Jänne, Kathleen Pfaff, Michael Y. Tolstorukov, Lynette M. Sholl, Fangxin Hong, Benjamin Chen, Xi-Tao Wang, Ana Lako, Eliezer M. Van Allen, Mark M. Awad, Cloud P. Paweletz, Prafulla C. Gokhale, Brendan Reardon, Hideo Watanabe, Maya Fridrikh, Aoi Akitsu, Shunsuke Kitajima, Israel Cañadas, Takahiko Murayama, Alison D. Santucci, Victor Quadros, Andrew Portell, Patrick H. Lizotte, Luke J. Taus, Michael J. Poitras, Jonathan S. Duke-Cohan, Bruce B. Reinhold, Saemi Han, Brandon Piel, Tran C. Thai, Deli Hong, Marco Campisi, Maria Saigí, Amir Vajdi, Jacquelyn O. Wolff, Erik H. Knelson, Navin R. Mahadevan
Small cell lung carcinoma (SCLC) is highly mutated, yet durable response to immune checkpoint blockade (ICB) is rare. SCLC also exhibits cellular plasticity, which could influence its immunobiology. Here we discover that a distinct subset of SCLC uni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4647caa0d1c61ca9a140b00973df6824
https://doi.org/10.1158/2159-8290.c.6549244.v1
https://doi.org/10.1158/2159-8290.c.6549244.v1
Autor:
David A. Barbie, Matthew G. Oser, Ellis L. Reinherz, Scott Rodig, Robin Edwards, Evisa Gjini, Pasi A. Jänne, Kathleen Pfaff, Michael Y. Tolstorukov, Lynette M. Sholl, Fangxin Hong, Benjamin Chen, Xi-Tao Wang, Ana Lako, Eliezer M. Van Allen, Mark M. Awad, Cloud P. Paweletz, Prafulla C. Gokhale, Brendan Reardon, Hideo Watanabe, Maya Fridrikh, Aoi Akitsu, Shunsuke Kitajima, Israel Cañadas, Takahiko Murayama, Alison D. Santucci, Victor Quadros, Andrew Portell, Patrick H. Lizotte, Luke J. Taus, Michael J. Poitras, Jonathan S. Duke-Cohan, Bruce B. Reinhold, Saemi Han, Brandon Piel, Tran C. Thai, Deli Hong, Marco Campisi, Maria Saigí, Amir Vajdi, Jacquelyn O. Wolff, Erik H. Knelson, Navin R. Mahadevan
Supplementary Table S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bdb01871ac4703e7fdf6229583a3de7
https://doi.org/10.1158/2159-8290.22540003.v1
https://doi.org/10.1158/2159-8290.22540003.v1
Autor:
David A. Barbie, Matthew G. Oser, Ellis L. Reinherz, Scott Rodig, Robin Edwards, Evisa Gjini, Pasi A. Jänne, Kathleen Pfaff, Michael Y. Tolstorukov, Lynette M. Sholl, Fangxin Hong, Benjamin Chen, Xi-Tao Wang, Ana Lako, Eliezer M. Van Allen, Mark M. Awad, Cloud P. Paweletz, Prafulla C. Gokhale, Brendan Reardon, Hideo Watanabe, Maya Fridrikh, Aoi Akitsu, Shunsuke Kitajima, Israel Cañadas, Takahiko Murayama, Alison D. Santucci, Victor Quadros, Andrew Portell, Patrick H. Lizotte, Luke J. Taus, Michael J. Poitras, Jonathan S. Duke-Cohan, Bruce B. Reinhold, Saemi Han, Brandon Piel, Tran C. Thai, Deli Hong, Marco Campisi, Maria Saigí, Amir Vajdi, Jacquelyn O. Wolff, Erik H. Knelson, Navin R. Mahadevan
Supplementary Figures 1-12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219fb0a74b9ede1ef293c6a7f98f274e
https://doi.org/10.1158/2159-8290.22540006.v1
https://doi.org/10.1158/2159-8290.22540006.v1
Autor:
Aoi Akitsu, Ellis L. Reinherz, Xiaolong Li, Abhinav Dubey, Kemin Tan, Matthew J. Lang, Jonathan S. Duke-Cohan, Jia-huai Wang, Paul W. Tetteh, Wonmuk Hwang, Haribabu Arthanari, Robert J. Mallis, Réka Mizsei, Gerhard Wagner
Publikováno v:
Science
PreTCRs use horizontal docking geometry The T cell receptor (TCR) recognizes peptide-bound major histocompatibility complex molecules (pMHCs) and consists of an α chain in association with a β chain. Both chains have hypervariable complementarity-d
Autor:
Yulia Makusheva, Soo-Hyun Chung, Aoi Akitsu, Natsumi Maeda, Takumi Maruhashi, Xiao-Qi Ye, Tomonori Kaifu, Shinobu Saijo, Haiyang Sun, Wei Han, Ce Tang, Yoichiro Iwakura
Publikováno v:
Experimental animals. 71(3)
Clec1A, a member of C-type lectin receptor family, has a carbohydrate recognition domain in its extracellular region, but no known signaling motif in the cytoplasmic domain. Clec1a is highly expressed in endothelial cells and weakly in dendritic cell
Autor:
Rebecca E. Hussey, Adrienne M. Luoma, Paul W. Tetteh, Kristine N. Brazin, Robert J. Mallis, Erin J. Adams, Hannah M. Stephens, Pedro A. Reche, Aoi Akitsu, Debasis Banik, Wonmuk Hwang, Brian Lawney, Ellis L. Reinherz, Sophie Krahnke, Jonathan S. Duke-Cohan, Dibyendu Kumar Das, Caitlin D. Castro, Matthew J. Lang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance TCR mechanosensing is thought necessary for digital sensitivity of αβT cell response to scant pMHC antigens. We use bioinformatic analysis, molecular dynamics, single-molecule optical tweezers techniques, cellular activation, and RNA-s
Autor:
Mallis, Robert J., Duke-Cohan, Jonathan S., Das, Dibyendu Kumar, Aoi Akitsu, Luoma, Adrienne M., Banik, Debasis, Stephens, Hannah M., Tetteh, Paul W., Castro, Caitlin D., Krahnke, Sophie, Hussey, Rebecca E., Lawney, Brian, Brazin, Kristine N., Reche, Pedro A., Wonmuk Hwang, Adams, Erin J., Lang, Matthew J., Reinherz, Ellis L.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 6/29/2021, Vol. 118 Issue 26, p1-12, 12p
Autor:
Yoichiro Iwakura, Aoi Akitsu
Publikováno v:
Immunology
Summary Interleukin‐17 (IL‐17) is a pro‐inflammatory cytokine and is involved in the development of many diseases. Recent studies have revealed that IL‐17‐producing γδ T cells (γδ17 cells) in addition to IL‐17‐producing CD4+ T cells