Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Aohua Wang"'
Autor:
Tiantian Yang, Aohua Wang, Di Nie, Weiwei Fan, Xiaohe Jiang, Miaorong Yu, Shiyan Guo, Chunliu Zhu, Gang Wei, Yong Gan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Displaying the correct surface functionality at the right time is important for efficient drug delivery. Here, the authors report on the pH-responsive, sequential presentation of cell-penetrating peptide and liver-targeting moiety designed to improve
Externí odkaz:
https://doaj.org/article/3d81ccdc25f54a5892122f0eaf3dad1a
Autor:
Jingyi Li, Yaqi Zhang, Miaorong Yu, Aohua Wang, Yu Qiu, Weiwei Fan, Lars Hovgaard, Mingshi Yang, Yiming Li, Rui Wang, Xiuying Li, Yong Gan
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 3, Pp 1460-1472 (2022)
Transporters are traditionally considered to transport small molecules rather than large-sized nanoparticles due to their small pores. In this study, we demonstrate that the upregulated intestinal transporter (PCFT), which reaches a maximum of 12.3-f
Externí odkaz:
https://doaj.org/article/98219f5a36ae4da8af469622a2e64706
Rapid transport of deformation-tuned nanoparticles across biological hydrogels and cellular barriers
Autor:
Miaorong Yu, Lu Xu, Falin Tian, Qian Su, Nan Zheng, Yiwei Yang, Jiuling Wang, Aohua Wang, Chunliu Zhu, Shiyan Guo, XinXin Zhang, Yong Gan, Xinghua Shi, Huajian Gao
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Penetration of the mucus and tumor interstitial matrix is an important consideration for drug delivery devices. Here, the authors report on a study into the optimization of rigidity for the transport of nanoparticles through biological hydrogels usin
Externí odkaz:
https://doaj.org/article/62b09f2339fb4640a540c588e511272e
Publikováno v:
Forests, Vol 11, Iss 3, p 306 (2020)
Phytophthora cinnamomi is a devastating pathogen causing root and crown rot and dieback diseases of nearly 5000 plant species. Accurate and rapid detection of P. cinnamomi plays a fundamental role within the current disease prevention and management
Externí odkaz:
https://doaj.org/article/1d82c28c7bf94b419062b243d4a34e9e
Autor:
Shiyan Guo, Yihan Zhou, Chunliu Zhu, Lefei Hu, Huixian Weng, Wenzhe Li, Hu Lei, Ning Wang, Aohua Wang, Miaorong Yu, Yong Gan
Publikováno v:
Chinese Chemical Letters. 33:1889-1894
Permeation enhancers (PEs), such as N-[8-(2-hydroxybenzoyl)amino]-caprylate (SNAC), have been reported to improve the oral absorption of various macromolecules. However, the bioavailabilities of these formulations are quite low and variable due to th
Autor:
Lars Hovgaard, Yiming Li, Miaorong Yu, Yaqi Zhang, Mingshi Yang, Jingyi Li, Yu Qiu, Weiwei Fan, Rui Wang, Aohua Wang, Yong Gan, Xiuying Li
Publikováno v:
Li, J, Zhang, Y, Yu, M, Wang, A, Qiu, Y, Fan, W, Hovgaard, L, Yang, M, Li, Y, Wang, R, Li, X & Gan, Y 2022, ' The upregulated intestinal folate transporters direct the uptake of ligand-modified nanoparticles for enhanced oral insulin delivery ', Acta Pharmaceutica Sinica B, vol. 12, no. 3, pp. 1460-1472 . https://doi.org/10.1016/j.apsb.2021.07.024
Transporters are traditionally considered to transport small molecules rather than large-sized nanoparticles due to their small pores. In this study, we demonstrate that the upregulated intestinal transporter (PCFT), which reaches a maximum of 12.3-f
Autor:
Tiantian Yang, Aohua Wang, Di Nie, Weiwei Fan, Xiaohe Jiang, Miaorong Yu, Shiyan Guo, Chunliu Zhu, Gang Wei, Yong Gan
Mutual interference between surface ligands on multifunctional nanoparticles remains a significant obstacle to achieving the optimal drug-delivery efficacy. Inspired by viruses that modulate surface proteins conformation to enable sequential display
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43ea94e4d9ae16cc3f3f5cc27cba590d
https://doi.org/10.21203/rs.3.rs-1480087/v1
https://doi.org/10.21203/rs.3.rs-1480087/v1
Autor:
Lu Xu, Faridoon, Ning Wang, Wei Huang, Chunliu Zhu, Miaorong Yu, Ejaj Ahmad, Aohua Wang, Yong Gan, Wei Zhang, Ziyue Xi, Jingyi Li
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 342
The efficacy of oral insulin drug delivery is seriously hampered by multiple gastrointestinal barriers, especially transepithelial barriers, including apical endocytosis, lysosomal degradation, cytosolic diffusion and basolateral exocytosis. In this
Autor:
Aohua Wang, Yue Wu, Stephen T. Buckley, Mingshi Yang, Yong Gan, Weiwei Fan, Lars Hovgaard, Jorrit Jeroen Water
Publikováno v:
Journal of Pharmaceutical Sciences. 108:2128-2135
Absorption enhancers are often a major component of solid oral peptide formulations as compared to the active pharmaceutical ingredient and excipients. This commonly results in poor tabletability that is hard to mitigate in direct compaction by addit
Autor:
Yuan Liu, Aohua Wang, Yaqi Zhang, Miaorong Yu, Xinghua Shi, Kun Qian, Falin Tian, Di Nie, Yiwei Yang, Yong Gan
Publikováno v:
Science Advances
Germ-mimetic nanoparticles with extended and packed polymer chains can overcome multiple barriers more efficiently.
Polyethylene glycols (PEGs) can improve the diffusivity of nanoparticles (NPs) in biological hydrogels, while extended PEG chains
Polyethylene glycols (PEGs) can improve the diffusivity of nanoparticles (NPs) in biological hydrogels, while extended PEG chains