Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Aochiu Chen"'
Autor:
Jeffrey T. Mindrebo, Ashay Patel, Woojoo E. Kim, Tony D. Davis, Aochiu Chen, Thomas G. Bartholow, James J. La Clair, J. Andrew McCammon, Joseph P. Noel, Michael D. Burkart
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The formation of C-C bonds in fatty acid and polyketide biosynthesis depends on β-ketoacyl-acyl carrier protein (ACP) synthases (KSs). Here, the authors present structures of E.coli KSs bound to substrate mimetic bearing ACPs, providing insights int
Externí odkaz:
https://doaj.org/article/8b2f324577e8467b8bb69a969b0ffd83
Publikováno v:
Biochemistry; 12/19/2023, Vol. 62 Issue 24, p3548-3553, 6p
Publikováno v:
Chemical science, vol 13, iss 15
The β-ketoacyl-acyl carrier protein synthase, or ketosynthase (KS), catalyses carbon-carbon bond formation in fatty acid and polyketide biosynthesis via a decarboxylative Claisen-like condensation. In prokaryotes, standalone elongating KSs interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9113c69e2d28df55111e8d7512354162
https://doi.org/10.1039/d1sc07256k
https://doi.org/10.1039/d1sc07256k
Autor:
Aochiu Chen, Jeffrey T. Mindrebo, Tony D. Davis, Woojoo E. Kim, Yohei Katsuyama, Ziran Jiang, Yasuo Ohnishi, Joseph P. Noel, Michael D. Burkart
Publikováno v:
Acta crystallographica. Section D, Structural biology. 78(Pt 9)
Ketosynthases (KSs) catalyse essential carbon–carbon bond-forming reactions in fatty-acid biosynthesis using a two-step, ping-pong reaction mechanism. In Escherichia coli, there are two homodimeric elongating KSs, FabB and FabF, which possess overl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ddac663ab6c89e806b5195c14705f5
https://pubmed.ncbi.nlm.nih.gov/36048156
https://pubmed.ncbi.nlm.nih.gov/36048156
Autor:
Aochiu Chen, Jeffrey T. Mindrebo, Tony D. Davis, Woojoo E. Kim, Yohei Katsuyama, Ziran Jiang, Yasuo Ohnishi, Joseph P. Noel, Michael D. Burkart
Ketosynthases (KS) catalyse essential carbon-carbon bond forming reactions in fatty acid biosynthesis using a two-step, ping-pong reaction mechanism. In E. coli, there are two homodimeric elongating KSs, FabB and FabF, both of which possess overlappi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22b6f1dac41ec51eb2215919587db698
https://doi.org/10.1101/2022.04.04.486996
https://doi.org/10.1101/2022.04.04.486996
Autor:
Jeffrey T. Mindrebo, Aochiu Chen, Woojoo E. Kim, Rebecca N. Re, Tony D. Davis, Joseph P. Noel, Michael D. Burkart
Publikováno v:
ACS Catal
Ketosynthases (KSs) catalyze carbon-carbon bond forming reactions in fatty acid synthases (FASs) and polyketide synthases (PKSs). KSs utilize a two-step ping pong kinetic mechanism to carry out an overall decarboxylative thio-Claisen condensation tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe1cb1dc8d76dc847171902e6bdcee6
https://europepmc.org/articles/PMC9524369/
https://europepmc.org/articles/PMC9524369/
Autor:
Aochiu Chen, Michael D. Burkart, Jeffrey T. Mindrebo, Joseph P. Noel, Tony D. Davis, Rebecca N. Re, Woojoo E. Kim
Ketosynthases (KSs) catalyze carbon-carbon bond forming reactions in fatty acid synthases (FASs) and polyketide synthases (PKSs). KSs utilize a two-step ping pong kinetic mechanism to carry out an overall decarboxylative thio-Claisen condensation tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f18dd97b5b465f22011ab467b06e1c22
https://doi.org/10.1101/2021.02.13.431092
https://doi.org/10.1101/2021.02.13.431092
Autor:
Yohei Katsuyama, Shinya Fushinobu, Aochiu Chen, Danyao Du, Yasuo Ohnishi, Tony D. Davis, Masanobu Horiuchi, Michael D. Burkart
Publikováno v:
Nat Chem Biol
In type II polyketide synthases (PKSs), the ketosynthase–chain length factor (KS–CLF) complex catalyzes polyketide chain elongation with the acyl carrier protein (ACP). Highly reducing type II PKSs, represented by IgaPKS, produce polyene structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e543e55885043f2574940341a6c61e9
https://europepmc.org/articles/PMC7556716/
https://europepmc.org/articles/PMC7556716/
Autor:
James J. La Clair, Woojoo E. Kim, Tony D. Davis, Jeffrey T. Mindrebo, Michael D. Burkart, Aochiu Chen, J. Andrew McCammon, Thomas G. Bartholow, Ashay Patel, J.P. Noel
Formation of carbon-carbon bonds via β-ketoacyl-acyl carrier protein (ACP) synthases (KS), are key reactions duringde novofatty acid and polyketide biosynthesis. KSs recognize multiple ACPs and choreograph ping-pong mechanisms often in an iterative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e2efb4c4fe905ca16f303eee6b6c8f4
https://doi.org/10.1101/644518
https://doi.org/10.1101/644518
Autor:
Aochiu Chen, Avi I. Flamholz, Cecilia Blikstad, Kelly M. Wetmore, Luke M. Oltrogge, John J Desmarais, Eli J Dugan, Spencer Diamond, J. Wang, Thomas G. Laughlin, David F. Savage
Many bacterial autotrophs rely on CO2concentrating mechanisms (CCMs) to assimilate carbon. Although many CCM proteins have been identified, including a 200+ MDa protein organelle called the carboxysome, a systematic screen of CCM components has not b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a27ddda1556dd4cb779f24f17795f15