Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Ao‐Ran Sui"'
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Akademický článek
Scorpion Venom Heat–Resistant Synthesized Peptide Increases Stress Resistance and Extends the Lifespan of Caenorhabditis elegans via the Insulin/IGF-1-Like Signal Pathway
Autor: Ying-Zi Wang, Song-Yu Guo, Rui-Li Kong, Ao-Ran Sui, Zhen-Hua Wang, Rong-Xiao Guan, Kundu Supratik, Jie Zhao, Shao Li
Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)
Improving healthy life expectancy by targeting aging-related pathological changes has been the spotlight of geroscience. Scorpions have been used in traditional medicine in Asia and Africa for a long time. We have isolated heat-resistant peptides fro
Externí odkaz: https://doaj.org/article/5ba577b2e10a4f02a344df623007f971
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4
Akademický článek
Scorpion Venom Heat-Resistant Peptide Attenuates Microglia Activation and Neuroinflammation
Autor: Xue-Fei Wu, Chun Li, Guang Yang, Ying-Zi Wang, Yan Peng, Dan-Dan Zhu, Ao-Ran Sui, Qiong Wu, Qi-Fa Li, Bin Wang, Na Li, Yue Zhang, Bi-Ying Ge, Jie Zhao, Shao Li
Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)
Background: Intervention of neuroinflammation in central nervous system (CNS) represents a potential therapeutic strategy for a host of brain disorders. The scorpion Buthus martensii Karsch (BmK) and its venom have long been used in the Orient to tre
Externí odkaz: https://doaj.org/article/5a88f2c5892842368e5bf1b9b5b11d64
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5
Scorpion venom heat-resistant synthetic peptide protects dopamine neurons against 6-hydroxydopamine neurotoxicity in C. elegans
Autor: Song-Yu, Guo, Rong-Xiao, Guan, Xiao-Dong, Chi, Yue-Zhang, Ao-Ran, Sui, Wei, Zhao, Kundu, Supratik, Jin-Yi, Yang, Jie, Zhao, Shao, Li
Publikováno v: Brain Research Bulletin. 190:195-203
Parkinson's disease (PD) is a common neurodegenerative disease. The main pathological feature is the degeneration and loss of dopaminergic neurons in the substantia nigra, which leads to the significant decrease of dopamine content in the striatum. O
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a054bb16b7ecaacb4f90d4fd8ddfd042
https://doi.org/10.1016/j.brainresbull.2022.09.022
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7
AQP4-A25Q Point Mutation in Mice Depolymerizes Orthogonal Arrays of Particles and Decreases Polarized Expression of AQP4 Protein in Astrocytic Endfeet at the Blood–Brain Barrier
Autor: Dan-Dan Zhu, Guang Yang, Yue-Lin Huang, Ting Zhang, Ao-Ran Sui, Na Li, Wei-Heng Su, Hai-Lun Sun, Jing-Jing Gao, Michael Ntim, Rong-Xiao Guan, Ling-Ling Jin, Jian Yu, Zhi-Yong Huang, Tong-Hui Ma, Shao Li
Publikováno v: J Neurosci
Aquaporin-4 (AQP4) is characterized by the formation of orthogonal arrays of particles (OAPs) comprising its M1 and M23 isoforms in the plasma membrane. However, the biological importance of OAP formation is obscure. Here, we developed an OAP depolym
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a20ef277f0b8f15aa1865b4a7b861850
https://europepmc.org/articles/PMC9637001/
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8
Scorpion venom heat‐resistant synthesized peptide ameliorates 6‐OHDA‐induced neurotoxicity and neuroinflammation: likely role of Na v 1.6 inhibition in microglia
Autor: Ao-Ran Sui, Donglai Li, Jie Zhao, Xue-Fei Wu, Xiujie Li, Khizar Khan, Na Li, Shao Li, Sheng Li, Bi-Ying Ge
Publikováno v: British Journal of Pharmacology. 178:3553-3569
BACKGROUND AND PURPOSE Microglia-related inflammation is associated with the pathology of Parkinson's disease. Functional voltage-gated sodium channels (VGSCs) are involved in regulating microglial function. Here, we aim to investigate the effects of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dba4a7602f3ac8df3362408890ce8a23
https://doi.org/10.1111/bph.15502
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