Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Anyong Xie"'
Autor:
Fang Zhang, Pengyi Yan, Huijing Yu, Huangying Le, Zixuan Li, Jiahuan Chen, Xiaodong Liang, Shiyan Wang, Weiting Wei, Li Liu, Yan Zhang, Xing Ji, Anyong Xie, Wantao Chen, Zeguang Han, William T. Pu, Sun Chen, Yingwei Chen, Kun Sun, Baoxie Ge, Bing Zhang
Publikováno v:
Cell Reports, Vol 32, Iss 4, Pp 107974- (2020)
Summary: Attenuated DNA repair leads to genomic instability and tumorigenesis. BRCA1/BARD1 are the best-known tumor suppressors that promote homology recombination (HR) and arrest cell cycle. However, it remains ambiguous whether and how their E3 lig
Externí odkaz:
https://doaj.org/article/abe438e6f2284744a70a670ae7b7c734
Autor:
Jinhua Han, Chunyan Ruan, Michael S. Y. Huen, Jiadong Wang, Anyong Xie, Chun Fu, Ting Liu, Jun Huang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The genomic instability phenotype characteristic of BRCA2-deficient cells is not fully mechanistically understood. Here the authors show BRCA2 inactivation destabilizes RPA-coated single-stranded DNA and leads to toxic non homologous end-joining even
Externí odkaz:
https://doaj.org/article/b460e0da0ea64118a5802381662c288d
Autor:
Josée Guirouilh-Barbat, Camille Gelot, Anyong Xie, Elodie Dardillac, Ralph Scully, Bernard S Lopez
Publikováno v:
PLoS Genetics, Vol 12, Iss 10, p e1006230 (2016)
DNA double-strand breaks (DSB) are very harmful lesions that can generate genome rearrangements. In this study, we used intrachromosomal reporters to compare both the efficiency and accuracy of end-joining occurring with close (34 bp apart) vs. dista
Externí odkaz:
https://doaj.org/article/fb7a564808c345528c10708661e020aa
Autor:
Andrea J Hartlerode, Yinghua Guan, Anbazhagan Rajendran, Kiyoe Ura, Gunnar Schotta, Anyong Xie, Jagesh V Shah, Ralph Scully
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49211 (2012)
Recruitment of 53BP1 to chromatin flanking double strand breaks (DSBs) requires γH2AX/MDC1/RNF8-dependent ubiquitination of chromatin and interaction of 53BP1 with histone H4 methylated on lysine 20 (H4K20me). Several histone methyltransferases have
Externí odkaz:
https://doaj.org/article/51153115b6584b1b91bea854d1bd5d6d
Autor:
David M. Livingston, Jarrod A. Marto, Myles Brown, Ralph Scully, Michael J. Eck, Eunyoung Park, Shiliang A. Cao, Elgene Lim, Anyong Xie, Kimberly J. Toomire, Scott B. Ficarro, Sarah A. Petit, Yiduo Hu
This file includes supplementary figure legends, supplementary methods, and supplementary references.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3278f377c44a95432d4f6c30356d1caa
https://doi.org/10.1158/2159-8290.22530476
https://doi.org/10.1158/2159-8290.22530476
Autor:
David M. Livingston, Jarrod A. Marto, Myles Brown, Ralph Scully, Michael J. Eck, Eunyoung Park, Shiliang A. Cao, Elgene Lim, Anyong Xie, Kimberly J. Toomire, Scott B. Ficarro, Sarah A. Petit, Yiduo Hu
This file includes Supplementary Figures S1-S9. Figure S1. PARP1 is a partner of the RAP80-BRCA1 complex and promotes BRCA1 PARsylation. Figure S2. In vitro PARP1-driven PARsylation of BRCA1 fragments. Figure S3. Identification of a BRCA1 sequence re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e05f0ce78325fe611e2a06512d302a
https://doi.org/10.1158/2159-8290.22530479.v1
https://doi.org/10.1158/2159-8290.22530479.v1
Autor:
Hai Liu, Yiyang Hong, Guanyu Wang, Haozhe Li, Xingjian Dong, Jingjing Tao, Anyong Xie, Yili Feng, Yihong Wang, Zhenyu Liuyang, Qinghua Dong, Jing Zhang, Zhongyang Jiang
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Radiation-induced oral mucositis is a major adverse event of radiotherapy. Severe oral mucositis may cause unwanted interruption in radiotherapy and reduce long-term survival in cancer patients receiving radiotherapy, but until now, there have been n
Publikováno v:
J Zhejiang Univ Sci B
The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) is widely used for targeted genomic and epigenomic modifications and imaging in cells and organisms, and holds tremendous promise in clinical ap
Autor:
Yi-Li Feng, Guo-Fang Yan, Hui Lin, Yang Huang, Hao Dan Li, Na Kong, Anyong Xie, Si-Cheng Liu, Tao Guo, Xiujun Cai, Ji-Feng Xiang, Ye Feng
Publikováno v:
Nucleic Acids Research
Phosphorylated histone H2AX, termed ‘γH2AX’, mediates the chromatin response to DNA double strand breaks (DSBs) in mammalian cells. H2AX deficiency increases the numbers of unrepaired DSBs and translocations, which are partly associated with def
Autor:
Baoxie Ge, Weiting Wei, Shiyan Wang, Sun Chen, Yingwei Chen, Jiahuan Chen, Li Liu, Wantao Chen, Xiaodong Liang, Bing Zhang, Xing Ji, Fang Zhang, Zixuan Li, Huangying Le, William T. Pu, Anyong Xie, Huijing Yu, Pengyi Yan, Yan Zhang, Kun Sun, Ze-Guang Han
Publikováno v:
Cell Reports, Vol 32, Iss 4, Pp 107974-(2020)
Summary Attenuated DNA repair leads to genomic instability and tumorigenesis. BRCA1/BARD1 are the best-known tumor suppressors that promote homology recombination (HR) and arrest cell cycle. However, it remains ambiguous whether and how their E3 liga