Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Anya Alayev"'
Autor:
David Musheyev, Anya Alayev
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 3, Iss 4, Pp 480-496 (2022)
Endocrine resistance is a major hurdle in the treatment of estrogen receptor (ER)-positive breast cancer. When abnormally regulated, molecular signals responsible for cellular proliferation, as well as ER itself, allow for cellular evasion of ER-depe
Externí odkaz:
https://doaj.org/article/da2f07bccb3f4b108c31fb6e76eac465
Autor:
David Musheyev, Esther Miller, Natania Birnbaum, Elisheva Miller, Shoshana Erblich, Alyssa Schuck, Anya Alayev
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0283047 (2023)
Breast cancer is the second leading cause of cancer-related deaths in women and triple-negative breast cancer (TNBC), in particular, is an aggressive and highly metastatic type of breast cancer that does not respond to established targeted therapies
Externí odkaz:
https://doaj.org/article/4a0f75a71a8c4095a2297fae4a450622
Autor:
Marina K. Holz, Olle Stål, Jane J. Yu, Bo Nordenskjöld, Tommy Fornander, Elin Lager, Naomi S. Schwartz, Anya Alayev, Lance D. Miller, Yang Sun, Josefine Bostner, Subrata Manna
ERRα protein expression and clinicopathological variables with respect to estrogen receptor (ER) and HER2 status.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d8789e95afadbc3761d60e870922765
https://doi.org/10.1158/1078-0432.22458858
https://doi.org/10.1158/1078-0432.22458858
Autor:
Marina K. Holz, Olle Stål, Jane J. Yu, Bo Nordenskjöld, Tommy Fornander, Elin Lager, Naomi S. Schwartz, Anya Alayev, Lance D. Miller, Yang Sun, Josefine Bostner, Subrata Manna
Supplementary figure 1: Validation of the ERRα antibody used for immunohistochemical analysis; Supplementary Figure 2: The prognostic value of ERRα protein expression and subcellular location in adjuvant-untreated ER-negative patients; Supplementar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22712a7dcd4758c30bbf7d0cdcfdc24
https://doi.org/10.1158/1078-0432.22458861.v1
https://doi.org/10.1158/1078-0432.22458861.v1
Autor:
Marina K. Holz, Olle Stål, Jane J. Yu, Bo Nordenskjöld, Tommy Fornander, Elin Lager, Naomi S. Schwartz, Anya Alayev, Lance D. Miller, Yang Sun, Josefine Bostner, Subrata Manna
Purpose: Estrogen-related receptor alpha (ERRα) signaling has recently been implicated in breast cancer. We investigated the clinical value of ERRα in randomized cohorts of tamoxifen-treated and adjuvant-untreated patients.Experimental Design: Cox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886b5063a94eb2db9119e2455100e02b
https://doi.org/10.1158/1078-0432.c.6524055.v1
https://doi.org/10.1158/1078-0432.c.6524055.v1
Autor:
David Musheyev, Anya Alayev
Publikováno v:
Exploration of targeted anti-tumor therapy. 3(4)
Endocrine resistance is a major hurdle in the treatment of estrogen receptor (ER)-positive breast cancer. When abnormally regulated, molecular signals responsible for cellular proliferation, as well as ER itself, allow for cellular evasion of ER-depe
Abstract 1976: Ras-Raf-MEK-ERK signaling pathway: a novel target of ERRα and tamoxifen in TNBC cells
Publikováno v:
Cancer Research. 81:1976-1976
TNBC, or triple-negative breast cancer, is an aggressive type of breast cancer that is associated with a worse prognosis, higher rates of metastases, and a poorer outcome. Historically, TNBC has been proven challenging to treat, due to disease hetero
Autor:
Xiaolei Liu, Elizabeth J. Kopras, Yang Liu, Chenggang Li, Anya Alayev, David R. Plas, Erik Zhang, Kantha Medepalli, Kouhei Masuda, Brian J. Siroky, David J. Kwiatkowski, Yang Sun, Marina K. Holz, Julia Sun, David Neal Franz, Michael T. Borchers, Darcy A. Krueger, Jamie K. Capal, Kathryn A. Wikenheiser-Brokamp, Jane J. Yu, Andrew R. Osterburg, Na Li, Maxwell Mays
Publikováno v:
Molecular Cancer Research. 15:1318-1330
Tuberous sclerosis complex (TSC) is a tumor-suppressor syndrome affecting multiple organs, including the brain, skin, kidneys, heart, and lungs. TSC is associated with mutations in TSC1 or TSC2, resulting in hyperactivation of mTOR complex 1 (mTORC1)
Autor:
Naomi S. Schwartz, Marina K. Holz, Rachel S. Salamon, Anya Alayev, Sara L. Wiener, Adi Y. Berman
Publikováno v:
Journal of Cellular Physiology. 232:436-446
Loss of TSC1 function, a crucial negative regulator of mTOR signaling, is a common alteration in bladder cancer. Mutations in other members of the PI3K pathway, leading to mTOR activation, are also found in bladder cancer. This provides rationale for
Autor:
Rachel S. Salamon, Rose Snyder, Anya Alayev, Rafael Cuesta, Naomi S. Schwartz, Marina K. Holz, Sara Malka Berger
Publikováno v:
Oncogene
Breast cancer is the leading cause of cancer-related deaths among women. Approximately 75% of breast cancers are estrogen receptor α (ERα) positive, underscoring the dependence of cancer cells on estrogen for growth and survival. Patients treated w