Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Anwu Zhou"'
Autor:
Michael A. Kalwat, Karina Rodrigues-dos-Santos, Derk D. Binns, Shuguang Wei, Anwu Zhou, Matthew R. Evans, Bruce A. Posner, Michael G. Roth, Melanie H. Cobb
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
PurposeType 1 diabetes (T1D) accounts for an estimated 5% of all diabetes in the United States, afflicting over 1.25 million individuals. Maintaining long-term blood glucose control is the major goal for individuals with T1D. In T1D, insulin-secretin
Externí odkaz:
https://doaj.org/article/5b86bc5e2aad4d56b25d4ff17c19aa48
Autor:
Chensu Wang, Hanspeter Niederstrasser, Peter M. Douglas, Rueyling Lin, Juan Jaramillo, Yang Li, Nathaniel W. Oswald, Anwu Zhou, Elizabeth A. McMillan, Saurabh Mendiratta, Zhaohui Wang, Tian Zhao, Zhiqaing Lin, Min Luo, Gang Huang, Rolf A. Brekken, Bruce A. Posner, John B. MacMillan, Jinming Gao, Michael A. White
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Activation of autophagy, via the transcription factor TFEB, is a promising strategy to treat metabolic diseases. Here, the authors report three novel classes of small molecules that promote TFEB nuclear translocation, and provide evidence for the the
Externí odkaz:
https://doaj.org/article/81b35dd22d994409b4c733145887247d
Autor:
Michael Ramirez, Satwik Rajaram, Robert J. Steininger, Daria Osipchuk, Maike A. Roth, Leanna S. Morinishi, Louise Evans, Weiyue Ji, Chien-Hsiang Hsu, Kevin Thurley, Shuguang Wei, Anwu Zhou, Prasad R. Koduru, Bruce A. Posner, Lani F. Wu, Steven J. Altschuler
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Cancer cells that survive initial drug treatment can persist in the presence of drugs. Here, the authors generate persister cells that are resistant to the EGFR tyrosine kinase inhibitor erlotinib and show by single cell analysis that multiple mechan
Externí odkaz:
https://doaj.org/article/bd1a3c50ad1a402d9bff233756a1c84e
Autor:
Chensu Wang, Hanspeter Niederstrasser, Peter M. Douglas, Rueyling Lin, Juan Jaramillo, Yang Li, Nathaniel W. Oswald, Anwu Zhou, Elizabeth A. McMillan, Saurabh Mendiratta, Zhaohui Wang, Tian Zhao, Zhiqaing Lin, Min Luo, Gang Huang, Rolf A. Brekken, Bruce A. Posner, John B. MacMillan, Jinming Gao, Michael A. White
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
The originally published version of this Article contained an error in the spelling of the author Nathaniel W. Oswald, which was incorrectly given as Nathaniel W. Olswald. This has now been corrected in both the PDF and HTML versions of the Article.
Externí odkaz:
https://doaj.org/article/687eb1f136554668849053fc57577f2a
Autor:
Kalwat, Michael A., Rodrigues-dos-Santos, Karina, Binns, Derk D., Shuguang Wei, Anwu Zhou, Evans, Matthew R., Posner, Bruce A., Roth, Michael G., Cobb, Melanie H.
Publikováno v:
Frontiers in Endocrinology; 2023, p1-10, 10p
Autor:
Sergio Wittlin, Sachel Mok, Benoît Laleu, Anwu Zhou, Susan A. Charman, Margaret A. Phillips, Tomas Yeo, David A. Fidock, Alisje Churchyard, Joseph M. Ready, Francisco-Javier Gamo, Ioanna Deni, John Okombo, Bruce A. Posner, Aloysus K. Lawong, Jessica L. Bridgford, Elizabeth A. Winzeler, Benigno Crespo, Michael J. Palmer, Hanspeter Niederstrasser, Josefine Striepen, Suraksha Gahalawat, Jake Baum, Nimisha Mittal
Publikováno v:
Journal of Medicinal Chemistry. 64:2739-2761
Malaria control programs continue to be threatened by drug resistance. To identify new antimalarials, we conducted a phenotypic screen and identified a novel tetrazole-based series that shows fast-kill kinetics and a relatively low propensity to deve
Autor:
Aloysus, Lawong, Suraksha, Gahalawat, John, Okombo, Josefine, Striepen, Tomas, Yeo, Sachel, Mok, Ioanna, Deni, Jessica L, Bridgford, Hanspeter, Niederstrasser, Anwu, Zhou, Bruce, Posner, Sergio, Wittlin, Francisco Javier, Gamo, Benigno, Crespo, Alisje, Churchyard, Jake, Baum, Nimisha, Mittal, Elizabeth, Winzeler, Benoît, Laleu, Michael J, Palmer, Susan A, Charman, David A, Fidock, Joseph M, Ready, Margaret A, Phillips
Publikováno v:
J Med Chem
Malaria control programs continue to be threatened by drug resistance. To identify new antimalarials we conducted a phenotypic screen and identified a novel tetrazole-based series that shows fast-kill kinetics and a relatively low propensity to devel
Autor:
Pierre-Emmanuel Rautou, Jihoon Nah, Junichi Sadoshima, Anwu Zhou, Yang Liu, Álvaro F. Fernández, Marion Tanguy, Beth Levine, Ming Chang Hu, Bruce A. Posner, Vanessa Ginet, Guanghua Xiao, Mingjun Shi, Julien Puyal, Valérie Paradis, Zhongju Zou
Publikováno v:
JCI insight, vol. 5, no. 1, pp. e133282
Autosis is a distinct form of cell death that requires both autophagy genes and the Na+,K+-ATPase pump. However, the relationship between the autophagy machinery and Na+,K+-ATPase is unknown. We explored the hypothesis that Na+,K+-ATPase interacts wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e283a34ec502b8fce3946670aad20b5
Autor:
Yongjie Wei, José Carlos Rodríguez Pérez, Jenna B. Yehl, Matthew J. Ranaghan, Beth Levine, Zhongju Zou, Bruce A. Posner, Yi Chun Kuo, Adam Skepner, Shuguang Wei, Joshua A. Bittker, Wei Chung Chiang, Anwu Zhou
Publikováno v:
ACS Chemical Biology. 13:2247-2260
Autophagy, a lysosomal degradation pathway, plays a crucial role in cellular homeostasis, development, immunity, tumor suppression, metabolism, prevention of neurodegeneration, and lifespan extension. Thus, pharmacological stimulation of autophagy ma
Publikováno v:
Wireless Personal Communications. 103:575-583
The automobile recall has been implemented in China for more than 10 years, the recall process has entered a mature stage and the recall rate also tends to be stable. However, the automobile recall, quite common in abroad, has a serious impact on the