Výsledky vyhledávání - "Anwar B. Beshir"

Supplementary Figure 1 from Polycomb Protein EZH2 Regulates Tumor Invasion via the Transcriptional Repression of the Metastasis Suppressor RKIP in Breast and Prostate Cancer

Autor: Kam C. Yeung, Ivana de la Serna, Ben Bonavida, Evan Keller, Fahd Al-Mulla, Stephanie Daignault, Rohit Mehra, Gabriel Fenteany, Anwar B. Beshir, Peter S. Bazeley, Sandy Beach, Sungdae Park, Jingwei Feng, Himangi Marathe, Stavroula Baritaki, Gang Ren

PDF file, 267KB, Supplementary figure 1. a) Heat maps of RKIP, EZH2, Snail and E-cad expression profiles obtained by interrogating publicly available DNA microarray expression datasets (33). The abbreviations are as follows: NAP: normal adjacent pros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7274b3422fbdada58ee90746f0b4a1
https://doi.org/10.1158/0008-5472.22389609.v1

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A Tale of Two Lab Courses: An Account and Reflection on the Teaching Challenges Experienced by Organic and Analytical Chemistry Laboratories During the COVID-19 Period

Autor: Kiet Tran, Abhay Vaze, Anwar B. Beshir

Publikováno v: Journal of Chemical Education

A comparison of the experiences of both organic and analytical lab faculty during the COVID-19 pandemic distance learning initiative is described here. Faculty of both lab courses experienced four shared challenges in the transition to the online for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ee07733fb57e83d8c256f3df469276

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Akademický článek

Cucurbitacin I inhibits cell motility by indirectly interfering with actin dynamics.

Autor: David A Knecht, Rebecca A LaFleur, Alem W Kahsai, Christian E Argueta, Anwar B Beshir, Gabriel Fenteany

Publikováno v: PLoS ONE, Vol 5, Iss 11, p e14039 (2010)

Cucurbitacins are plant natural products that inhibit activation of the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway by an unknown mechanism. They are also known to cause changes in the organization of the

Externí odkaz: https://doaj.org/article/70c4fe0d9283497bbc5fc0cee1a22462

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Diversity Through a Branched Reaction Pathway: Generation of Multicyclic Scaffolds and Identification of Antimigratory Agents

Autor: Ohyun Kwon, Sabrina Castellano, Gabriel Fenteany, Sape S. Kinderman, Zhiming Wang, Anwar B. Beshir, Christian E. Argueta

Publikováno v: Chemistry: A European Journal, 17(2), 649-654. Wiley-VCH Verlag

A library of 91 heterocyclic compounds composed of 16 distinct scaffolds has been synthesized through a sequence of phosphine-catalyzed ring-forming reactions, Tebbe reactions, Diels-Alder reactions, and, in some cases, hydrolysis. This effort in div

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dde39a6245463b37e2d586326437569
https://doi.org/10.1002/chem.201002195

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Synthesis and structure–activity relationships of metal–ligand complexes that potently inhibit cell migration

Autor: Sankar K. Guchhait, José A. Gascón, Anwar B. Beshir, Gabriel Fenteany

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:498-504

We screened the National Cancer Institute Diversity Set compound collection for small molecules that affect mammalian cell migration and identified NSC 295642 as an inhibitor of cell motility with nanomolar potency. We found by LC–MS and X-ray crys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876b43b7ff9bb3a95642834b8df399c0
https://doi.org/10.1016/j.bmcl.2007.11.099

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Polycomb protein EZH2 regulates tumor invasion via the transcriptional repression of the metastasis suppressor RKIP in breast and prostate cancer

Autor: Stavroula Baritaki, Sungdae Park, Peter S. Bazeley, Evan T. Keller, Sandy Beach, Jingwei Feng, Fahd Al-Mulla, Ivana L. de la Serna, Kam C. Yeung, Himangi Marathe, Stephanie Daignault, Rohit Mehra, Ben Bonavida, Gang Ren, Gabriel Fenteany, Anwar B. Beshir

Publikováno v: Cancer research. 72(12)

Epigenetic modifications such as histone methylation play an important role in human cancer metastasis. Enhancer of zeste homolog 2 (EZH2), which encodes the histone methyltransferase component of the polycomb repressive complex 2 (PRC2), is overexpr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5dc9834d49411d15378b249ea369b3e
https://pubmed.ncbi.nlm.nih.gov/22505648

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Locostatin Disrupts Association of Raf Kinase Inhibitor Protein With Binding Proteins by Modifying a Conserved Histidine Residue in the Ligand-Binding Pocket

Autor: Lochana C. Menikarachchi, José A. Gascón, Anwar B. Beshir, Gabriel Fenteany, Christian E. Argueta

Raf kinase inhibitor protein (RKIP) interacts with a number of different proteins and regulates multiple signaling pathways. Here, we show that locostatin, a small molecule that covalently binds RKIP, not only disrupts interactions of RKIP with Raf-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca0eb171fb765326cdd6300a42d8ecb
https://europepmc.org/articles/PMC3121171/

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Raf kinase inhibitor protein positively regulates cell-substratum adhesion while negatively regulating cell-cell adhesion

Autor: Huihui Tang, Gabriel Fenteany, Kam C. Yeung, Kevin T. Mc Henry, Roberto Montesano, Anwar B. Beshir, Shoutian Zhu

Publikováno v: Journal of cellular biochemistry, Vol. 103, No 3 (2008) pp. 972-85

Raf kinase inhibitor protein (RKIP) regulates a number of cellular processes, including cell migration. Exploring the role of RKIP in cell adhesion, we found that overexpression of RKIP in Madin-Darby canine kidney (MDCK) epithelial cells increases a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0048574f021c83409edccd401f657a36
https://archive-ouverte.unige.ch/unige:2110

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