Oxidative stress and docosahexaenoic acid injury lead to increased necroptosis and ferroptosis in retinal pigment epithelium

Autor: Almar Neiteler, Anwar A. Palakkan, Kevin M. Gallagher, James A. Ross

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Abstract Age-related macular degeneration (AMD) is a complex disease caused by different genetic and environmental risk factors leading to loss of cells in the central part of the retina. Oxidative stress appears to be an important environmental risk

Externí odkaz: https://doaj.org/article/abf3bd8c408b4ac48d0084b4abffa633

Renal engineering: Strategies to address the problem of the ureter

Autor: Jamie A. Davies, Mona Elhendawi, Anwar A. Palakkan, May Sallam

Current techniques for making renal organoids generate tis- sues that show function when transplanted into a host, but they have no ureter through which urine can drain. There are at least 4 possible strategies for adding a ureter: connecting to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2659::7498bfa80b57d732c25f69e6b7a486be
https://zenodo.org/record/7638892

Differentiation of a contractile, ureter-like tissue, from Embryonic Stem cell-derived ureteric bud and Ex-Fetu mesenchyme

Autor: Lorna Marson, Anwar Azad Palakkan, Mona Elhendawi, Christopher G. Mills, Julia Tarnick, Jamie A. Davies, May Sallam

Publikováno v: Sallam, M, Palakkan, A, Mills, C, Tarnick, J, Elhendawi, M, Marson, L & Davies, J 2020, ' Differentiation of a contractile, ureter-like tissue, from Embryonic Stem cell-derived ureteric bud and Ex-Fetu mesenchyme ', Journal of the American Society of Nephrology, vol. 31, no. 10, pp. 2253-2262 . https://doi.org/10.1681/ASN.2019101075

Background There is intense interest in replacing kidneys from stem cells. It is now possible to produce, from embryonic or induced pluripotent stem cells, kidney organoids that represent immature kidneys and display some physiologic functions. Howev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13edbe4a005d6b82659e5b45e48eb549
https://hdl.handle.net/20.500.11820/bd1f1a20-df3c-4efe-84a2-35667f398461

Human Induced Pluripotent Stem Cell-Derived Definitive Endoderm Bulk Culture and Hepatic Differentiation

Autor: Anwar A, Palakkan, Jyoti, Nanda, James A, Ross

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1994

We have developed a method to bulk culture definitive endoderm cells generated from human iPSCs which can be stored and differentiated to hepatocytes. Human iPSC-derived definitive endoderm cells were sorted based on the expression of CXCR4. The sort

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::77591c5db24d4d322084c90963251c67
https://pubmed.ncbi.nlm.nih.gov/31124103

Standardizing transdifferentiation of rabbit bone marrow mesenchymal stem cells to corneal lineage by simulating corneo-limbal cues

Autor: Anwar Azad Palakkan, Tilak Prasad, Anil Kumar Pr, Saumi Mathews, T. V. Kumary, Balul Venugopa

Publikováno v: Journal of Stem Cell Research and Medicine. 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf1fa9fc3982d4d053c8da6b916e9367
https://doi.org/10.15761/jscrm.1000119