Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Anushka C. Galasiti Kankanamalage"'
Autor:
Chamandi S. Dampalla, Athri D. Rathnayake, Anushka C. Galasiti Kankanamalage, Yunjeong Kim, Krishani Dinali Perera, Harry Nhat Nguyen, Matthew J. Miller, Trent K. Madden, Hunter R. Picard, Hayden A. Thurman, Maithri M. Kashipathy, Lijun Liu, Kevin P. Battaile, Scott Lovell, Kyeong-Ok Chang, William C. Groutas
Publikováno v:
Journal of medicinal chemistry. 65(11)
The worldwide impact of the ongoing COVID-19 pandemic on public health has made imperative the discovery and development of direct-acting antivirals aimed at targeting viral and/or host targets. SARS-CoV-2 3C-like protease (3CL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38cfbb5ab002c494a881639063e91ab
https://pubmed.ncbi.nlm.nih.gov/35638577
https://pubmed.ncbi.nlm.nih.gov/35638577
Autor:
Yunjeong Kim, Hongwei Liu, Anushka C Galasiti Kankanamalage, Sahani Weerasekara, Duy H Hua, William C Groutas, Kyeong-Ok Chang, Niels C Pedersen
Publikováno v:
PLoS Pathogens, Vol 12, Iss 5, p e1005650 (2016)
[This corrects the article DOI: 10.1371/journal.ppat.1005531.].
Externí odkaz:
https://doaj.org/article/2b89e5c55d964faf823724452da99743
Autor:
Yunjeong Kim, Hongwei Liu, Anushka C Galasiti Kankanamalage, Sahani Weerasekara, Duy H Hua, William C Groutas, Kyeong-Ok Chang, Niels C Pedersen
Publikováno v:
PLoS Pathogens, Vol 12, Iss 3, p e1005531 (2016)
Coronaviruses infect animals and humans causing a wide range of diseases. The diversity of coronaviruses in many mammalian species is contributed by relatively high mutation and recombination rates during replication. This dynamic nature of coronavir
Externí odkaz:
https://doaj.org/article/e109fd72db904f9baf1f4c95c7706550
Autor:
Chunshan Xie, Qian Zhang, Anindya Sarkar, Joseph G. Naglich, Heng Cheng, Prasanna Sivaprakasam, Sanjeev Gangwar, Anushka C. Galasiti Kankanamalage, Dale L. Boger
Publikováno v:
Med Chem Res
A comprehensive SAR study of a putative TLR 3/8/9 agonist was conducted. Despite the excitement surrounding the potential of the first small molecule TLR3 agonist with a compound that additionally displayed agonist activity for TLR8 and TLR9, compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d364d59216dd425471435e4566507e53
https://pubmed.ncbi.nlm.nih.gov/34421287
https://pubmed.ncbi.nlm.nih.gov/34421287
Autor:
Scott Lovell, Vishnu C. Damalanka, Kyeong-Ok Chang, William C. Groutas, Anthony R. Fehr, A.D. Rathnayake, Stanley Perlman, N. Mehzabeen, Gerald H. Lushington, Yunjeong Kim, Anushka C. Galasiti Kankanamalage, Kevin P. Battaile
Publikováno v:
European Journal of Medicinal Chemistry
There are currently no approved vaccines or small molecule therapeutics available for the prophylaxis or treatment of Middle East Respiratory Syndrome coronavirus (MERS-CoV) infections. MERS-CoV 3CL protease is essential for viral replication; conseq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9decd322911b3d1f46facd972034ae7c
https://doi.org/10.1016/j.ejmech.2018.03.004
https://doi.org/10.1016/j.ejmech.2018.03.004
Autor:
Hongwei Liu, Yunjeong Kim, Kyeong-Ok Chang, Michael J. Bannasch, William C. Groutas, Juliana M. Meadows, Anushka C. Galasiti Kankanamalage, Niels C Pedersen, Chrissy Eckstrand
Publikováno v:
Journal of Feline Medicine and Surgery
Objectives The safety and efficacy of the 3C-like protease inhibitor GC376 was tested on a cohort of client-owned cats with various forms of feline infectious peritonitis (FIP). Methods Twenty cats from 3.3–82 months of age (mean 10.4 months) with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518267f5578ab4e1a8dd05cfa98d2176
http://europepmc.org/articles/PMC5871025
http://europepmc.org/articles/PMC5871025
Autor:
Anushka C. Galasiti Kankanamalage, Steven C. Cardinale, A.D. Rathnayake, Michelle M. Butler, William C. Groutas, Terry L. Bowlin, Yunjeong Kim, Kyeong-Ok Chang, Kevin R. Alliston
Publikováno v:
Journal of Medicinal Chemistry. 60:6239-6248
Ester and carbamate prodrugs of aldehyde bisulfite adduct inhibitors were synthesized in order to improve their pharmacokinetic and pharmacodynamic properties. The inhibitory activity of the compounds against norovirus 3C-like protease in enzyme and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64acea92c68a9f4276157cca99c69743
https://doi.org/10.1021/acs.jmedchem.7b00497
https://doi.org/10.1021/acs.jmedchem.7b00497
Autor:
William C. Groutas, Anushka C. Galasiti Kankanamalage, Kyeong-Ok Chang, N. Mehzabeen, D. M.Padmasankha Dissanayake, Vishnu C. Damalanka, Sean T. Doyle, Gerald H. Lushington, Yunjeong Kim, Scott Lovell, Amer F. Alsoudi, A.D. Rathnayake, Kevin P. Battaile, Pathum M. Weerawarna
Publikováno v:
European Journal of Medicinal Chemistry
Human noroviruses are the primary cause of epidemic and sporadic acute gastroenteritis. The worldwide high morbidity and mortality associated with norovirus infections, particularly among the elderly, immunocompromised patients and children, constitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5303166f3e6abcbe081b0a16e1cb84c5
https://doi.org/10.1016/j.ejmech.2016.11.027
https://doi.org/10.1016/j.ejmech.2016.11.027
Autor:
Kevin P. Battaile, William C. Groutas, Kevin R. Alliston, Kyeong-Ok Chang, Vishnu C. Damalanka, Gerald H. Lushington, Scott Lovell, Yunjeong Kim, N. Mehzabeen, Anushka C. Galasiti Kankanamalage, Pathum M. Weerawarna
Publikováno v:
European Journal of Medicinal Chemistry
Outbreaks of acute gastroenteritis caused by noroviruses constitute a public health concern worldwide. To date, there are no approved drugs or vaccines for the management and prophylaxis of norovirus infections. A potentially effective strategy for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74d33f5bcdfa668b9c000a25065aad5
https://doi.org/10.1016/j.ejmech.2016.04.013
https://doi.org/10.1016/j.ejmech.2016.04.013
Autor:
Pathum M. Weerawarna, Yunjeong Kim, Anushka C. Galasiti Kankanamalage, William C. Groutas, Kyeong-Ok Chang
Publikováno v:
Expert Opinion on Therapeutic Patents
Human noroviruses are the primary causative agents of acute gastroenteritis and are a pressing public health burden worldwide. There are currently no vaccines or small molecule therapeutics available for the treatment or prophylaxis of norovirus infe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6328c5f808565074f8ac5656a6a5e32