Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Anusha P. Dias"'
Autor:
Alexander F Palazzo, Michael Springer, Yoko Shibata, Chung-Sheng Lee, Anusha P Dias, Tom A Rapoport
Publikováno v:
PLoS Biology, Vol 5, Iss 12, p e322 (2007)
In eukaryotic cells, most mRNAs are exported from the nucleus by the transcription export (TREX) complex, which is loaded onto mRNAs after their splicing and capping. We have studied in mammalian cells the nuclear export of mRNAs that code for secret
Externí odkaz:
https://doaj.org/article/a287424096ac43c68485a6fdcd2d525f
Autor:
Chung-Sheng Lee, Mark P. Jedrychowski, Anusha P. Dias, Arvind H. Patel, Jeanne L. Hsu, Robin Reed
Publikováno v:
Nucleic Acids Research
The conserved RNA helicase DDX3 is of major medical importance due to its involvement in numerous cancers, human hepatitis C virus (HCV) and HIV. Although DDX3 has been reported to have a wide variety of cellular functions, its precise role remains o
Autor:
Anusha P. Dias, Karyn M. Austin, Robin Reed, Maggie Malsch, Chung Sheng Lee, Karthik A. Ganapathi, Akiko Shimamura
Publikováno v:
Blood. 110:1458-1465
Shwachman-Diamond syndrome (SDS) is an autosomal recessive disorder characterized by bone marrow failure, exocrine pancreatic dysfunction, and leukemia predisposition. Mutations in the SBDS gene are identified in most patients with SDS. SBDS encodes
Autor:
Robin Reed, Ke Wang, Min Shi, Yanhua Du, Anusha P. Dias, She Chen, Malcolm Whitman, Lantian Wang, Enduo Wang, Heng Zhang, Ke Sheng, Changlan Zhu, Hong Cheng
Publikováno v:
Cell Discovery
mRNAs containing premature termination codons (PTCs) are known to be degraded via nonsense-mediated mRNA decay (NMD). Unexpectedly, we found that mRNAs containing any type of PTCs (UAA, UAG, and UGA) are detained in the nucleus, whereas their wild-ty
Publikováno v:
Cell. 127:1389-1400
SummaryPre-mRNAs undergo splicing to remove introns, and the spliced mRNA is exported to the cytoplasm for translation. Here we investigated the mechanism for recruitment of the conserved mRNA export machinery (TREX complex) to mRNA. We show that the
Autor:
Erich Grotewold, Anusha P. Dias
Publikováno v:
Biochemical Engineering Journal. 14:207-216
Transcription factors are emerging as powerful tools to manipulating plant metabolism. R2R3 Myb genes have expanded dramatically in the plants, where they are involved in the regulation of plant form and metabolic diversity. However, the function of
Publikováno v:
Plant Physiology. 131:610-620
R2R3 Myb genes are widely distributed in the higher plants and comprise one of the largest known families of regulatory proteins. Here, we provide an evolutionary framework that helps explain the origin of the plant-specific R2R3 Myb genes from widel
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 108(44)
A great deal is known about the export of spliced mRNAs, but little is known about the export of mRNAs encoded by human cellular genes that naturally lack introns. Here, we investigated the requirements for export of three naturally intronless mRNAs
The TREX complex, which functions in mRNA export, is recruited to mRNA during splicing. Both the splicing machinery and the TREX complex are concentrated in 20-50 discrete foci known as nuclear speckle domains. In this study, we use a model system wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e19d9f26777d571b619cbbc56157850
https://europepmc.org/articles/PMC3793428/
https://europepmc.org/articles/PMC3793428/
The numerous steps in protein gene expression are extensively coupled to one another through complex networks of physical and functional interactions. Indeed, >25 coupled reactions, often reciprocal, have been documented among such steps as transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39a086ebd87b5db9a9f96cc2c2dea14
https://europepmc.org/articles/PMC2265164/
https://europepmc.org/articles/PMC2265164/