Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Anush Oganesian"'
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142787 (2015)
α1a Adrenergic receptors (α1aARs) are the predominant AR subtype in human vascular smooth muscle cells (SMCs). α1aARs in resistance vessels are crucial in the control of blood pressure, yet the impact of naturally occurring human α1aAR genetic va
Externí odkaz:
https://doaj.org/article/1e302a1672474a29826fc37760c896f4
Autor:
Maren Kleine-Brueggeney, Anush Oganesian, Ekaterina Babaeva, Debra A. Schwinn, Irina Gradinaru
Publikováno v:
Cellular Signalling. 26:1985-1997
The role of naturally occurring human α1a-Adrenergic Receptor (α1aAR) genetic variants associated with cardiovascular disorders is poorly understood. Here, we present the novel findings that expression of human α1aAR-247R (247R) genetic variant in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629a7991163db771292a737792500330
https://doi.org/10.1016/j.cellsig.2014.05.007
https://doi.org/10.1016/j.cellsig.2014.05.007
Publikováno v:
Anesthesia & Analgesia. 117:33-37
Genomic variation is an important factor in why supposedly “similar” patients react differently to drugs, have different disease course(s), and varying clinical outcomes. This review provides an update on concepts in modern genomic medicine with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b4bd19ffd7023dee04d91e9c966f455
https://doi.org/10.1213/ane.0b013e31829ec0c7
https://doi.org/10.1213/ane.0b013e31829ec0c7
Publikováno v:
Circulation Research. 119
α 1- adrenergic receptors (α 1a , α 1b , α 1d ), members of G protein-coupled receptor (GPCR) family, regulate stress-facilitated changes in the cardiovascular (CV) system and human blood pressure (BP) via smooth muscle cell (SMC) proliferation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c42f7eddeb84756c68e1651eeec77238
https://doi.org/10.1161/res.119.suppl_1.308
https://doi.org/10.1161/res.119.suppl_1.308
Publikováno v:
Proceedings of the National Academy of Sciences. 108:19796-19801
We previously identified a naturally occurring human SNP, G247R, in the third intracellular loop of the α 1a -adrenergic receptor (α 1a -247R) and demonstrated that constitutive expression of α 1a -247R results in twofold increased cell proliferat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433625c04650c9a46cd794b0583d2370
https://doi.org/10.1073/pnas.1116271108
https://doi.org/10.1073/pnas.1116271108
Publikováno v:
Journal of Biological Chemistry. 285:10487-10496
Phogrin is a transmembrane protein expressed in cells with stimulus-coupled peptide hormone secretion, including pancreatic beta cells, in which it is localized to the membrane of insulin-containing dense-core vesicles. By sequence, phogrin is a memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f76c5a41a5031081249e8d644b6381
https://doi.org/10.1074/jbc.m109.066563
https://doi.org/10.1074/jbc.m109.066563
Publikováno v:
Hypertension. 66
Objectives : Human α 1 adrenergic receptors (AR), members of G protein-coupled receptor superfamily (GPCR) regulate blood pressure via smooth muscle cell (SMC) proliferation and vasoconstriction. We showed that α 1a AR-G247R (247R) genetic variant,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e370aa63360e4ffed7051f0b3fb3714
https://doi.org/10.1161/hyp.66.suppl_1.p194
https://doi.org/10.1161/hyp.66.suppl_1.p194
Publikováno v:
Hypertension. 64
Objectives: Alpha1-Adrenergic Receptors (α1ARs), members of the G protein-coupled receptor (GPCR) superfamily, play a major role in regulating cardiovascular (CV) function. Recently, we discovered that naturally occurring human α1aAR-G247R (247R) g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::914c56758c17c328bd7381bed2fd05b6
https://doi.org/10.1161/hyp.64.suppl_1.052
https://doi.org/10.1161/hyp.64.suppl_1.052
Publikováno v:
Circulation Research. 115
Activation of α 1 -Adrenergic Receptors (α 1 ARs), members of the G protein-coupled receptor (GPCR) superfamily, in response to stimulation of the sympathetic nervous system by catecholamines plays a major role in regulating cardiovascular (CV) fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1344ffe6c3372c6d922064e64704eec5
https://doi.org/10.1161/res.115.suppl_1.200
https://doi.org/10.1161/res.115.suppl_1.200
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 34
Activation of α1-Adrenergic Receptors (α1ARs), members of the G protein-coupled receptor (GPCR) superfamily, in response to stimulation of the sympathetic nervous system by catecholamines plays a major role in regulating cardiovascular (CV) functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc76b3267c47473cb67e8ded5eb05016
https://doi.org/10.1161/atvb.34.suppl_1.348
https://doi.org/10.1161/atvb.34.suppl_1.348