Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Anurag Sharadendu"'
Autor:
Hugo M. Vargas, Yang Xu, Jerry Siu, Janet Buys, Michelle Horner, Jian Lin, Ashis Saha, Han Xu, Michele McElvain, Anurag Sharadendu, Scot Middleton, Roland Burli, Yael Marantz, Dalia Segal, Kevin Salyers, Mercedes Lobera, Dilara Mccauley, Srinivas Chereku, Xiang Yu, Nili Schutz, Michael Schrag
Publikováno v:
ACS Medicinal Chemistry Letters. 2:97-101
We have discovered novel benzofuran-based S1P1 agonists with excellent in vitro potency and selectivity. 1-((4-(5-Benzylbenzofuran-2-yl)-3-fluorophenyl)methyl) azetidine-3-carboxylic acid (18) is a potent S1P1 agonist with >1000× selectivity over S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff8291efcc95ecdaf3a6ce8e57343599
https://doi.org/10.1021/ml100227q
https://doi.org/10.1021/ml100227q
Autor:
Anurag Sharadendu, Saeed Ramezani, Martin A. Shapiro, H. D. Hollis Showalter, E. Themis Joannides, Xiujuan Wu, Judy Yip, Bird Paul, John M. Domagala, Brian M. Watson, Stephen J. Gracheck, Tuan P. Tran, Chan Ha, Rajeshwar Singh, Edmund L. Ellsworth, Michael Stier, Joseph P. Sanchez, Dai Q. Nguyen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1312-1320
A series of 3-aminoquinazolinediones was synthesized and evaluated for its antibacterial and DNA gyrase activity. The SAR around the quinazolinedione core was explored and the optimal substitutions were combined to give two compounds, 2r and 2s , wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4af73f438dba10d7f564e0a34ff3416
https://doi.org/10.1016/j.bmcl.2006.12.005
https://doi.org/10.1016/j.bmcl.2006.12.005
Autor:
Anurag Sharadendu, Larry Weiler
Publikováno v:
Tetrahedron Letters. 39:2443-2446
Reduction of 3-oxo-15-hexadecanolide ( 1 ) was carried out with high stereoselectivity and good chemical yield. The relative stereochemistry of the minor β-hydroxy lactone 3 was determined by X-ray crystallography. The dianion of 2 underwent stereos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7924c89d9a6735a9ac432833843712b4
https://doi.org/10.1016/s0040-4039(98)00236-6
https://doi.org/10.1016/s0040-4039(98)00236-6
Autor:
Michelle Horner, Kristine M. Muller, Xuxia Zhang, Xiang Yu, Nili Schutz, Jerry Siu, Dalia Rivenzon-Segal, Roland Burli, Zhang Zhaoda, Susana C. Neira, Hugo M. Vargas, Alexander J. Pickrell, Jennifer E. Golden, Yang Xu, Victor J. Cee, Michael Schrag, Scot Middleton, Jian Lin, Yael Marantz, Andrea Itano, Mercedes Lobera, Han Xu, Brian A. Lanman, Michele McElvain, Janet Buys, Anu Gore, Srinivasa R Cheruku, Anurag Sharadendu, Mike Fiorino, Mike Frohn
Optimization of a benzofuranyl S1P1 agonist lead compound (3) led to the discovery of 1-(3-fluoro-4-(5-(2-fluorobenzyl)benzo[d]thiazol-2-yl)benzyl)azetidine-3-carboxylic acid (14), a potent S1P1 agonist with minimal activity at S1P3. Dosed orally at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4114b66ba763963fd644e7ff1f508317
https://europepmc.org/articles/PMC4018108/
https://europepmc.org/articles/PMC4018108/
Publikováno v:
ChemInform. 27
Alkylation of the dianion of 3-oxo-13-tetradecanolide(1) was carried out in high stereoselectivity and chemical yield. The relative stereochemistry of the two distant chiral centers were determined by chemical transformation of 2 to dibenzoates 6 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e200fbea75d7fb05105ab03366984e4d
https://doi.org/10.1002/chin.199643151
https://doi.org/10.1002/chin.199643151
Autor:
Anurag Sharadendu, Larry Weiler
Publikováno v:
ChemInform. 29
Reduction of 3-oxo-15-hexadecanolide ( 1 ) was carried out with high stereoselectivity and good chemical yield. The relative stereochemistry of the minor β-hydroxy lactone 3 was determined by X-ray crystallography. The dianion of 2 underwent stereos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f57a451be12ca05146cbeb9928219cd
https://doi.org/10.1002/chin.199828197
https://doi.org/10.1002/chin.199828197
Autor:
Oren M. Becker, Merav Fichman, Alexander Heifetz, Chen Dongli, Michael Kauffman, Dhanoa Dale S, Yael Marantz, Srinivasa Rao Cheruku, Sharon Shacham, Raphael Nudelman, Silvia Noiman, Anurag Sharadendu, Pradyumna Mohanty
Publikováno v:
Journal of medicinal chemistry. 49(11)
We report the discovery of a novel, potent, and selective amidosulfonamide nonazapirone 5-HT1A agonist for the treatment of anxiety and depression, which is now in Phase III clinical trials for generalized anxiety disorder (GAD). The discovery of 20m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31e77b183143d1a3fe29804546d7fdf
https://pubmed.ncbi.nlm.nih.gov/16722631
https://pubmed.ncbi.nlm.nih.gov/16722631