Zobrazeno 1 - 10
of 319
pro vyhledávání: '"Anuradha Ray"'
Autor:
Benjamin S. Johnson, Daniela Farkas, Rabab El-Mergawy, Jessica A. Adair, Ajit Elhance, Moemen Eltobgy, Francesca M. Coan, Lexie Chafin, Jessica A. Joseph, Alex Cornwell, Finny J. Johns, Lorena Rosas, Mauricio Rojas, Laszlo Farkas, Joseph S. Bednash, James D. Londino, Prabir Ray, Anuradha Ray, Valerian Kagan, Janet S. Lee, Bill B. Chen, Rama K. Mallampalli
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The severity of bacterial pneumonia can be worsened by impaired innate immunity resulting in ineffective pathogen clearance. We describe a mitochondrial protein, aspartyl-tRNA synthetase (DARS2), which is released in circulation during bacte
Externí odkaz:
https://doaj.org/article/2405260ebea942bc953a30e62d0266df
Autor:
Kazuhiro Yamada, Claudette St. Croix, Donna B. Stolz, Yulia Y. Tyurina, Vladimir A. Tyurin, Laura R. Bradley, Alexander A. Kapralov, Yanhan Deng, Xiuxia Zhou, Qi Wei, Bo Liao, Nobuhiko Fukuda, Mara Sullivan, John Trudeau, Anuradha Ray, Valerian E. Kagan, Jinming Zhao, Sally E. Wenzel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract A stable mitochondrial pool is crucial for healthy cell function and survival. Altered redox biology can adversely affect mitochondria through induction of a variety of cell death and survival pathways, yet the understanding of mitochondria
Externí odkaz:
https://doaj.org/article/1c733dcdc5e7478d914aed5291e53938
Autor:
Sudipta Das, Tomasz W. Kaminski, Brent T. Schlegel, William Bain, Sanmei Hu, Akruti Patel, Sagar L. Kale, Kong Chen, Janet S. Lee, Rama K. Mallampalli, Valerian E. Kagan, Dhivyaa Rajasundaram, Bryan J. McVerry, Prithu Sundd, Georgios D. Kitsios, Anuradha Ray, Prabir Ray
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Respiratory infection by Pseudomonas aeruginosa, common in hospitalized immunocompromised and immunocompetent ventilated patients, can be life-threatening because of antibiotic resistance. This raises the question of whether the host’s imm
Externí odkaz:
https://doaj.org/article/20bfc93bfde543cea0885eef6a5ff29b
Autor:
Tomeka L. Suber, Stacy G. Wendell, Steven J. Mullett, Benjamin Zuchelkowski, William Bain, Georgios D. Kitsios, Bryan J. McVerry, Prabir Ray, Anuradha Ray, Rama K. Mallampalli, Yingze Zhang, Faraaz Shah, Seyed Mehdi Nouraie, Janet S. Lee
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background Fatty acid oxidation (FAO) defects have been implicated in experimental models of acute lung injury and associated with poor outcomes in critical illness. In this study, we examined acylcarnitine profiles and 3-methylhistidine as
Externí odkaz:
https://doaj.org/article/e91f4ac58d6b42149004a4ddaf38fe22
Autor:
Georgios D. Kitsios, Seyed Mehdi Nouraie, Shulin Qin, Yingze Zhang, Prabir Ray, Anuradha Ray, Janet S. Lee, Alison Morris, Bryan J. McVerry, William Bain
Publikováno v:
ERJ Open Research, Vol 9, Iss 3 (2023)
Externí odkaz:
https://doaj.org/article/267e0ba88d604c9a84b4a16ecdc6cc52
Autor:
William Bain, Mohammadreza Tabary, Sara R. Moore, Xiaojing An, Georgios D. Kitsios, Bryan J. McVerry, Prabir Ray, Anuradha Ray, Rama K. Mallampalli, Viviana P. Ferreira, Janet S. Lee, S. Mehdi Nouraie
Publikováno v:
ERJ Open Research, Vol 9, Iss 3 (2023)
Background Effective regulation of complement activation may be crucial to preserving complement function during acute respiratory distress syndrome (ARDS). Factor H is the primary negative regulator of the alternative pathway of complement. We hypot
Externí odkaz:
https://doaj.org/article/3243b63a7e464800b085d884997730f5
Autor:
Tadao Nagasaki, Alexander J. Schuyler, Jinming Zhao, Svetlana N. Samovich, Kazuhiro Yamada, Yanhan Deng, Scott P. Ginebaugh, Stephanie A. Christenson, Prescott G. Woodruff, John V. Fahy, John B. Trudeau, Detcho Stoyanovsky, Anuradha Ray, Yulia Y. Tyurina, Valerian E. Kagan, Sally E. Wenzel
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 1 (2022)
Altered redox biology challenges all cells, with compensatory responses often determining a cell’s fate. When 15 lipoxygenase 1 (15LO1), a lipid-peroxidizing enzyme abundant in asthmatic human airway epithelial cells (HAECs), binds phosphatidyletha
Externí odkaz:
https://doaj.org/article/45e6d435807b449cbb11a73fc2795bf4
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100847- (2021)
Summary: Bulk expression data from heterogeneous cell populations pose a challenge for investigators, as differences in cell numbers and transcriptional programs may complicate analysis. To improve the performance of bulk RNA sequencing on mixed popu
Externí odkaz:
https://doaj.org/article/4299c19b6f05428b986c836bdf3b8a83
Autor:
Matthew J. Camiolo, Xiuxia Zhou, Qi Wei, Humberto E. Trejo Bittar, Naftali Kaminski, Anuradha Ray, Sally E. Wenzel
Publikováno v:
JCI Insight, Vol 6, Iss 21 (2021)
Asthma is a common disease with profoundly variable natural history and patient morbidity. Heterogeneity has long been appreciated, and much work has focused on identifying subgroups of patients with similar pathobiological underpinnings. Previous st
Externí odkaz:
https://doaj.org/article/ac27576b5c58412c83d0dff478b50aff
Autor:
Matthew J. Camiolo, Xiaoying Zhou, Timothy B. Oriss, Qi Yan, Michael Gorry, William Horne, John B. Trudeau, Kathryn Scholl, Wei Chen, Jay K. Kolls, Prabir Ray, Florian J. Weisel, Nadine M. Weisel, Nima Aghaeepour, Kari Nadeau, Sally E. Wenzel, Anuradha Ray
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108974- (2021)
Summary: Clinical definitions of asthma fail to capture the heterogeneity of immune dysfunction in severe, treatment-refractory disease. Applying mass cytometry and machine learning to bronchoalveolar lavage (BAL) cells, we find that corticosteroid-r
Externí odkaz:
https://doaj.org/article/c9fa672d9c7c4ce5951873f34b1a1ccf