Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Anuraag Bukkuri"'
Autor:
Anuraag Bukkuri, Kenneth J. Pienta, Robert H. Austin, Emma U. Hammarlund, Sarah R. Amend, Joel S. Brown
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The polyaneuploid cancer cell (PACC) state promotes cancer lethality by contributing to survival in extreme conditions and metastasis. Recent experimental evidence suggests that post-therapy PACC-derived recurrent populations display cross-r
Externí odkaz:
https://doaj.org/article/bcbd6c09da064051a756848a4f23f88c
Autor:
Anuraag Bukkuri, Joel S. Brown
Publikováno v:
Methods in Ecology and Evolution, Vol 14, Iss 6, Pp 1475-1488 (2023)
Abstract State‐structured populations are ubiquitous in biology, from the age‐structure of animal societies to the life cycles of parasitic species. Understanding how this structure contributes to eco‐evolutionary dynamics is critical not only
Externí odkaz:
https://doaj.org/article/f5185b2413cf47558820f86f7965ec5a
Autor:
Anuraag Bukkuri, Kenneth J. Pienta, Sarah R. Amend, Robert H. Austin, Emma U. Hammarlund, Joel S. Brown
Publikováno v:
Ecology and Evolution, Vol 13, Iss 10, Pp n/a-n/a (2023)
Abstract Evolvability is the capacity of a population to generate heritable variation that can be acted upon by natural selection. This ability influences the adaptations and fitness of individual organisms. By viewing this capacity as a trait, evolv
Externí odkaz:
https://doaj.org/article/7e4d9299408e4b9199e84cb6dae86b05
Autor:
Anuraag Bukkuri, Kenneth J. Pienta, Robert H. Austin, Emma U. Hammarlund, Sarah R. Amend, Joel S. Brown
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Therapeutic resistance is one of the main reasons for treatment failure in cancer patients. The polyaneuploid cancer cell (PACC) state has been shown to promote resistance by providing a refuge for cancer cells from the effects of therapy an
Externí odkaz:
https://doaj.org/article/5e255d74321e44159eab4104663af1f8
Autor:
Anuraag Bukkuri, Kenneth J. Pienta, Robert H. Austin, Emma U. Hammarlund, Sarah R. Amend, Joel S. Brown
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Recent evidence suggests that a polyaneuploid cancer cell (PACC) state may play a key role in the adaptation of cancer cells to stressful environments and in promoting therapeutic resistance. The PACC state allows cancer cells to pause cell
Externí odkaz:
https://doaj.org/article/f9e258e630024871bac773c4cd734baa
Publikováno v:
npj Systems Biology and Applications, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract The tragedy of the commons occurs when competition among individual members of a group leads to overexploitation of a shared resource to the detriment of the overall population. We hypothesize that cancer cells may engage in a tragedy of the
Externí odkaz:
https://doaj.org/article/350476ca1f5b4d3a9f3e5a1f82bc87fb
Autor:
Anuraag Bukkuri, Frederick R. Adler
Publikováno v:
Frontiers in Ecology and Evolution, Vol 9 (2021)
All biological systems depend on signals for coordination: signals which pass information among agents that run the gamut from cells to organisms. However, their very importance makes signals vulnerable to subversion. How can a receiver know whether
Externí odkaz:
https://doaj.org/article/f88e01fe75694302a506de430675b2c9
Publikováno v:
Frontiers in Ecology and Evolution, Vol 9 (2021)
Intratumoral molecular cancer cell heterogeneity is conventionally ascribed to the accumulation of random mutations that occasionally generate fitter phenotypes. This model is built upon the “mutation-selection” paradigm in which mutations drive
Externí odkaz:
https://doaj.org/article/3631624fa9904105aed7c00c08651a18
Publikováno v:
Frontiers in Artificial Intelligence, Vol 4 (2021)
The emergence of the information age in the last few decades brought with it an explosion of biomedical data. But with great power comes great responsibility: there is now a pressing need for new data analysis algorithms to be developed to make sense
Externí odkaz:
https://doaj.org/article/8ff16926d04b47d58eafc45cbe55a484
Autor:
Anuraag Bukkuri
Publikováno v:
Biomath, Vol 9, Iss 2 (2020)
We consider a mathematical model of human immunodeficiency virus (HIV) infection dynamics of T lymphocyte (T cell), infected T cell, and viral populations under reverse transcriptase inhibitor (RTI) andprotease inhibitor (PI) treatment. Existence, un
Externí odkaz:
https://doaj.org/article/bcc20d099d474e0f8914c8336d635968