Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Anura L. Jayewardene"'
Autor:
Anura L. Jayewardene, Francesca T. Aweeka, Patricia Lizak, Florence Marzan, Xiaohua Li, Liusheng Huang
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 50:959-965
To study the pharmacokinetic profile of artemether in children and in the context of antiviral drugs for HIV infected patients co-infected with malaria, an LC-MS/MS method was developed and validated to simultaneously determine artemether and its met
Autor:
Terrence F. Blaschke, Francesca T. Aweeka, S Au, Jingduan Chi, Lourdes Thevanayagam, Toshiro Motoya, Judith A. Stone, Anura L. Jayewardene
Publikováno v:
HIV Medicine. 7:122-128
Objectives To determine the characteristics of the binding of nelfinavir and active M8 to α1-acid glycoprotein (AAG) and human serum albumin (HSA), and to examine the displacement effects of drugs binding extensively to AAG (ritonavir and saquinavir
Autor:
Patricia Lizak, Miriam Chernoff, John Spritzler, Jeffrey M. Jacobson, Carol Braun Trapnell, Francesca T. Aweeka, Anura L. Jayewardene, S. Eralp Bellibas
Publikováno v:
The Journal of Clinical Pharmacology. 41:1091-1097
Thalidomide has increasing clinical benefits, including the healing of aphthous ulcers in patients with HIV. Unfortunately, pharmacological information addressing the pharmacokinetics (PK) of this compound in HIV patients is limited. Concern exists a
Autor:
Silvija I. Staprans, S.E. Bellibas, Tatjana Novakovic-Agopian, Richard W. Price, Patricia Lizak, Brian P. Kearney, Anura L. Jayewardene, Francesca T. Aweeka
Publikováno v:
Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 20:39-43
OBJECTIVE To assess the penetration of the HIV-1 protease inhibitor, nelfinavir, into cerebrospinal fluid (CSF). DESIGN Nelfinavir, a commonly used HIV-1 protease inhibitor (PI), is highly effective for reducing plasma viral load. It is deployed clin
Autor:
Dirk Lebrecht, Nils Venhoff, Fran Aweeka, Ana C Venhoff, Anura L Jayewardene, Ulrich A. Walker
Publikováno v:
JAIDS Journal of Acquired Immune Deficiency Syndromes. 48:114-116
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 21:2947-2956
The size of intracellular 2′-deoxythymidine-5′-triphosphate (dTTP) pools is an important indicator of cytotoxicity in cells exposed to antiviral drugs and mutagens. We describe an ion paired reverse-phase high performance liquid chromatographic (
Autor:
Patricia Lizak, Anura L. Jayewardene, Françoise Kramer, Charles van der Horst, John G. Gambertoglio, Bruce Polsky, Francesca T. Aweeka, William Tong, Lisa Emrick, Mark A. Jacobson
Publikováno v:
Clinical Pharmacology & Therapeutics. 57:403-412
Introduction The use of foscarnet and ganciclovir as a combination treatment for cytomegalovirus retinitis is increasing because of limitations associated with single agent therapy. Methods The pharmacokinetics of foscarnet and ganciclovir were deter
Publikováno v:
Journal of Liquid Chromatography. 17:4157-4167
An ion paired reversed - phase high performance liquid chromatographic assay for ceftizoxime in human abscess fluid using barbital as the internal standard is described. Sample preparation consists of precipitating the proteins in diluted abscess flu
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 12:1311-1316
A paired ion reversed-phase high performance liquid chromatographic method for simultaneous determination of iothalamic acid (Io) and para aminohippuric acid (PAH) in urine is described. The method uses a single internal standard for both drugs. The
Publikováno v:
Journal of Liquid Chromatography. 17:2395-2412
An ion paired reversed—phase high performance liquid chromatographic assay for iothalamic acid and para aminohippuric acid in the same sample of plasma is described. The analysis uses one internal standard for both drugs. Sample preparation consist