Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Anupama Shirali"'
Autor:
Zahra Rattray, Gang Deng, Shenqi Zhang, Anupama Shirali, Christopher K. May, Xiaoyong Chen, Benedette J. Cuffari, Jun Liu, Pan Zou, Nicholas J.W. Rattray, Caroline H. Johnson, Valentina Dubljevic, James A. Campbell, Anita Huttner, Joachim M. Baehring, Jiangbing Zhou, James E. Hansen
Publikováno v:
JCI Insight, Vol 6, Iss 14 (2021)
The blood-brain barrier (BBB) prevents antibodies from penetrating the CNS and limits conventional antibody-based approaches to brain tumors. We now show that ENT2, a transporter that regulates nucleoside flux at the BBB, may offer an unexpected path
Externí odkaz:
https://doaj.org/article/21ffa509b1144881818a9f13faf9e597
Autor:
Shu-fei Lin PhD, Frederic Bois PhD, Daniel Holden BA, Nabeel Nabulsi PhD, Richard Pracitto MS, Hong Gao MS, Michael Kapinos BS, Jo-ku Teng BS, Anupama Shirali PhD, Jim Ropchan PhD, Richard E. Carson PhD, Charles S. Elmore PhD, Neil Vasdev PhD, Yiyun Huang PhD
Publikováno v:
Molecular Imaging, Vol 16 (2017)
The myriad physiological functions of γ-amino butyric acid (GABA) are mediated by the GABA-benzodiazepine receptor complex comprising of the GABA A , GABA B , and GABA C groups. The various GABA A subunits with region-specific distributions in the b
Externí odkaz:
https://doaj.org/article/497bac56eec240b688692fea73023b35
Autor:
Xiaoyong Chen, Benedette J. Cuffari, Valentina Dubljevic, Anupama Shirali, Jiangbing Zhou, James A. Campbell, Stephen C. Suits, Kim M. O’Sullivan, James E. Hansen
Publikováno v:
ImmunoHorizons. 6:356-365
Nuclear-penetrating anti-DNA autoantibodies have therapeutic potential as delivery agents and in targeting DNA and the DNA damage response (DDR). Derivatives of such Abs have advanced to human testing in genetic disease and are in preparation for onc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c5a8b20cc9bd6138f2fc2085b107fa
https://doi.org/10.4049/immunohorizons.2100091
https://doi.org/10.4049/immunohorizons.2100091
Autor:
Xiaoyong Chen, Xiangjun Tang, Benedette J. Cuffari, Caroline Tang, Xingchun Gao, Philip W. Noble, Melissa R. Young, Olivia M. Turk, Anupama Shirali, Joseph Gera, Robert N. Nishimura, Jiangbing Zhou, James E. Hansen
Cytoplasmic DNA triggers a cGAS-mediated signaling cascade that promotes an innate immune response and is potentially actionable in cancer immunotherapy. Here we show that a cytoplasmic-localizing lupus anti-DNA autoantibody activates cGAS and facili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::687060f5a805c416e3b8b25dbe9dcbe9
https://doi.org/10.1101/2023.02.11.527649
https://doi.org/10.1101/2023.02.11.527649
Autor:
Hongmei Jia, Yingfang He, Shu-fei Lin, Jim Ropchan, Anupama Shirali, Evan Baum, Yiyun Huang, Michael Kapinos, Zhengxin Cai, Hong Gao, Daniel Holden, Songye Li
Publikováno v:
ACS Chemical Neuroscience. 11:1673-1681
We report a convenient radiosynthesis and the first positron emission tomography (PET) imaging evaluation of [18F]FBFP as a potent sigma-1 (σ1) receptor radioligand with advantageous characteristics. [18F]FBFP was synthesized in one step from an iod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34d47c9efe3c9f8819d722ce0cbaf6c8
https://doi.org/10.1021/acschemneuro.0c00171
https://doi.org/10.1021/acschemneuro.0c00171
Autor:
Xiaoai Wu, Nabeel Nabulsi, Daniel Holden, David Labaree, Marcel Lindemann, Takuya Toyonaga, Jim Ropchan, Songye Li, Shu-fei Lin, Yiyun Huang, Evan Baum, Richard Pracitto, Wenjie Zhang, Sjoerd J. Finnema, Zhengxin Cai, Anupama Shirali, Richard E. Carson
Publikováno v:
ACS Chemical Neuroscience. 11:592-603
Synaptic vesicle glycoprotein 2A (SV2A) is a 12-pass transmembrane glycoprotein ubiquitously expressed in presynaptic vesicles. In vivo imaging of SV2A using PET has potential applications in the d...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fdaa22f516164376fbe2797aeed6ea8
https://doi.org/10.1021/acschemneuro.9b00618
https://doi.org/10.1021/acschemneuro.9b00618
Autor:
Christopher K. May, Valentina Dubljevic, Nicholas J. W. Rattray, Jun Liu, Anita J. Huttner, Benedette Cuffari, James A. Campbell, Caroline H. Johnson, Gang Deng, Anupama Shirali, Jiangbing Zhou, Zahra Rattray, Pan Zou, Joachim M. Baehring, Shenqi Zhang, Xiaoyong Chen, James E. Hansen
Publikováno v:
JCI Insight
The blood-brain barrier (BBB) prevents antibodies from penetrating the CNS and limits conventional antibody-based approaches to brain tumors. We now show that ENT2, a transporter that regulates nucleoside flux at the BBB, may offer an unexpected path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a523d86871b548f02cb725986fe8dc
https://strathprints.strath.ac.uk/76801/1/Rattray_etal_JCII_2021_ENT2_facilitates_brain_endothelial_cell_penetration_and_blood_brain_barrier.pdf
https://strathprints.strath.ac.uk/76801/1/Rattray_etal_JCII_2021_ENT2_facilitates_brain_endothelial_cell_penetration_and_blood_brain_barrier.pdf
Autor:
Teresa Lara-Jaime, Beata Planeta, David Matuskey, Richard E. Carson, Jim Ropchan, Anupama Shirali, Shannan Henry, Yiyun Huang, Susan Bellaire, Michael Kapinos, David Labaree, Jean-Dominique Gallezot, Mark Walzer, Richard Pracitto, Nabeel Nabulsi, Gerard J. Marek, Hong Gao, Shu-fei Lin, Nancy Yuan
Publikováno v:
Journal of Nuclear Medicine. 60:1140-1146
The 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme converts cortisone to cortisol and participates in the regulation of glucocorticoid levels in tissues. 11β-HSD1 is expressed in the liver, kidney, adipose tissue, placenta, and brain. 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08a4febdb7cf656fc48bfc735235eca6
https://doi.org/10.2967/jnumed.118.219766
https://doi.org/10.2967/jnumed.118.219766
Autor:
Anupama Shirali, Antonio Navarro, Nabeel Nabulsi, Teresa Lara-Jaime, Soheila Najafzadeh, Cynthia Darshini Jesudason, Lawrence J. Slieker, Vanessa N. Barth, Richard E. Carson, Yiyun Huang, Daniel Holden, David Labaree, Jim Ropchan, Hong Gao, Frederic Bois, Ming-Qiang Zheng, Shu-fei Lin, Nancy Kant
Publikováno v:
Journal of Nuclear Medicine. 60:1147-1153
The M1 muscarinic acetylcholine receptor (mAChR) plays an important role in learning and memory, and therefore is a target for development of drugs for treatment of cognitive impairments in Alzheimer’s disease and schizophrenia. The availability of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a27b56f1fbc3e5047f028354844b285b
https://doi.org/10.2967/jnumed.118.222034
https://doi.org/10.2967/jnumed.118.222034
Autor:
Anupama Shirali, Jim Ropchan, Jo-ku Teng, Ming-Qiang Zheng, Mika Naganawa, Songye Li, Yiyun Huang, Shu-fei Lin, Hong Gao, Richard Pracitto
Publikováno v:
Molecular Pharmaceutics. 16:1523-1531
The kappa opioid receptor (KOR) is involved in depression, alcoholism, and drug abuse. The current agonist radiotracer 11C-GR103545 is not ideal for imaging KOR due to its slow tissue kinetics in h...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e5f0434f8e5728bf9888f2431be495
https://doi.org/10.1021/acs.molpharmaceut.8b01209
https://doi.org/10.1021/acs.molpharmaceut.8b01209