Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Anupama Reddy"'
Autor:
Scott M. Haake, Erin J. Plosa, Jonathan A. Kropski, Lindsay A. Venton, Anupama Reddy, Fabian Bock, Betty T. Chang, Allen J. Luna, Kateryna Nabukhotna, Zhi-Qi Xu, Rebecca A. Prather, Sharon Lee, Harikrishna Tanjore, Vasiliy V. Polosukhin, Olga M. Viquez, Angela Jones, Wentian Luo, Matthew H. Wilson, W. Kimryn Rathmell, Pierre P. Massion, Ambra Pozzi, Timothy S. Blackwell, Roy Zent
Publikováno v:
JCI Insight, Vol 7, Iss 15 (2022)
Integrins — the principal extracellular matrix (ECM) receptors of the cell — promote cell adhesion, migration, and proliferation, which are key events for cancer growth and metastasis. To date, most integrin-targeted cancer therapeutics have disr
Externí odkaz:
https://doaj.org/article/265f440d006847c6922cd3a32eff3553
Autor:
Jianguo Huang, Mark Chen, Melodi Javid Whitley, Hsuan-Cheng Kuo, Eric S. Xu, Andrea Walens, Yvonne M. Mowery, David Van Mater, William C. Eward, Diana M. Cardona, Lixia Luo, Yan Ma, Omar M. Lopez, Christopher E. Nelson, Jacqueline N. Robinson-Hamm, Anupama Reddy, Sandeep S. Dave, Charles A. Gersbach, Rebecca D. Dodd, David G. Kirsch
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Site-specific recombination and CRISPR-Cas9 have been used to generate genetically engineered mouse models of cancer. Here the authors compare sarcomas generated using both systems and see similar genetic and cellular phenotypes, suggesting CRISPR-Ca
Externí odkaz:
https://doaj.org/article/43b8c0058e5a4216b4fb7dadf1a3b419
Autor:
Dora Posfai, Kayla Sylvester, Anupama Reddy, Jack G Ganley, Johannes Wirth, Quinlan E Cullen, Tushar Dave, Nobutaka Kato, Sandeep S Dave, Emily R Derbyshire
Publikováno v:
PLoS Pathogens, Vol 14, Iss 5, p e1007057 (2018)
Within the liver a single Plasmodium parasite transforms into thousands of blood-infective forms to cause malaria. Here, we use RNA-sequencing to identify host genes that are upregulated upon Plasmodium berghei infection of hepatocytes with the hypot
Externí odkaz:
https://doaj.org/article/5afc4dbb8588431aaa25768808694a9a
Autor:
Sumedha Roy, Amanda J. Moore, Cassandra Love, Anupama Reddy, Deepthi Rajagopalan, Sandeep S. Dave, Leping Li, Cornelis Murre, Yuan Zhuang
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
A family of transcription factors known as E proteins, and their antagonists, Id proteins, regulate T cell differentiation at critical developmental checkpoints. Id proteins promote the differentiation of conventional αβ T cells and suppress the ex
Externí odkaz:
https://doaj.org/article/bd7c443808564641a3bbc5923eb0e58a
Autor:
Priya H. Dedhia, MD, PhD, Kerri Lopez, BS, Anupama Reddy, DO, Jonathan B. McHugh, MD, Eric Langer, DO, Barbra S. Miller, MD
Publikováno v:
AACE Clinical Case Reports, Vol 3, Iss 2, Pp e106-e110 (2017)
ABSTRACT: Objective: Identification of multiple endocrine abnormalities can result from endocrine or nonendocrine malignancies, genetic syndromes, or systemic diseases. Here, we evaluate an unusual presentation of several endocrine pathologies.Method
Externí odkaz:
https://doaj.org/article/2f2bbd1a35604c0d969228a112951f77
Autor:
Anupama Reddy, Joseph D Growney, Nick S Wilson, Caroline M Emery, Jennifer A Johnson, Rebecca Ward, Kelli A Monaco, Joshua Korn, John E Monahan, Mark D Stump, Felipa A Mapa, Christopher J Wilson, Janine Steiger, Jebediah Ledell, Richard J Rickles, Vic E Myer, Seth A Ettenberg, Robert Schlegel, William R Sellers, Heather A Huet, Joseph Lehár
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146635 (2016)
Externí odkaz:
https://doaj.org/article/59c3f93f2d5c4482aef340a64a791f66
Autor:
Anupama Reddy, Joseph D Growney, Nick S Wilson, Caroline M Emery, Jennifer A Johnson, Rebecca Ward, Kelli A Monaco, Joshua Korn, John E Monahan, Mark D Stump, Felipa A Mapa, Christopher J Wilson, Janine Steiger, Jebediah Ledell, Richard J Rickles, Vic E Myer, Seth A Ettenberg, Robert Schlegel, William R Sellers, Heather A Huet, Joseph Lehár
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138486 (2015)
Death Receptor 5 (DR5) agonists demonstrate anti-tumor activity in preclinical models but have yet to demonstrate robust clinical responses. A key limitation may be the lack of patient selection strategies to identify those most likely to respond to
Externí odkaz:
https://doaj.org/article/65b59ba5d911495fa33f7b9acb527174
A meta-analysis approach for characterizing pan-cancer mechanisms of drug sensitivity in cell lines.
Autor:
Kendric Wang, Raunak Shrestha, Alexander W Wyatt, Anupama Reddy, Joseph Lehár, Yuzhou Wang, Anna Lapuk, Colin C Collins
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103050 (2014)
Understanding the heterogeneous drug response of cancer patients is essential to precision oncology. Pioneering genomic analyses of individual cancer subtypes have begun to identify key determinants of resistance, including up-regulation of multi-dru
Externí odkaz:
https://doaj.org/article/99cce34b08ca4448b564d292a3de2905
Autor:
Kshitij Wagh, Aatish Bhatia, Gabriela Alexe, Anupama Reddy, Vijay Ravikumar, Michael Seiler, Michael Boemo, Ming Yao, Lee Cronk, Asad Naqvi, Shridar Ganesan, Arnold J Levine, Gyan Bhanot
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44751 (2012)
The Maasai are a pastoral people in Kenya and Tanzania, whose traditional diet of milk, blood and meat is rich in lactose, fat and cholesterol. In spite of this, they have low levels of blood cholesterol, and seldom suffer from gallstones or cardiac
Externí odkaz:
https://doaj.org/article/142fd9fa43584b858db1017907d65c59
Autor:
Beat Nyfeler, Yan Chen, Xiaoyan Li, Maria Pinzon-Ortiz, Zuncai Wang, Anupama Reddy, Elina Pradhan, Rita Das, Joseph Lehár, Robert Schlegel, Peter M Finan, Z Alexander Cao, Leon O Murphy, Alan Huang
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48548 (2012)
The mammalian target of rapamycin (mTOR) is regulated by oncogenic growth factor signals and plays a pivotal role in controlling cellular metabolism, growth and survival. Everolimus (RAD001) is an allosteric mTOR inhibitor that has shown marked effic
Externí odkaz:
https://doaj.org/article/32cb2963c67d49559e5f3173e7cb5b38