Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Anup D Shah"'
Autor:
Pablo M Casillas-Espinosa, Alison Anderson, Anna Harutyunyan, Crystal Li, Jiyoon Lee, Emma L Braine, Rhys D Brady, Mujun Sun, Cheng Huang, Christopher K Barlow, Anup D Shah, Ralf B Schittenhelm, Richelle Mychasiuk, Nigel C Jones, Sandy R Shultz, Terence J O'Brien
Publikováno v:
eLife, Vol 12 (2023)
There are no pharmacological disease-modifying treatments with an enduring effect to mitigate the seizures and comorbidities of established chronic temporal lobe epilepsy (TLE). This study aimed to evaluate for disease modifying effects of sodium sel
Externí odkaz:
https://doaj.org/article/4e8722171a41474ebb674b4e800efafa
Autor:
Anna Harutyunyan, Debbie Chong, Rui Li, Anup D. Shah, Zahra Ali, Cheng Huang, Christopher K. Barlow, Piero Perucca, Terence J. O’Brien, Nigel C. Jones, Ralf B. Schittenhelm, Alison Anderson, Pablo M. Casillas-Espinosa
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 6063 (2022)
Absence epilepsy syndromes are part of the genetic generalized epilepsies, the pathogenesis of which remains poorly understood, although a polygenic architecture is presumed. Current focus on single molecule or gene identification to elucidate epilep
Externí odkaz:
https://doaj.org/article/f97e819b694a4e54817e1b21a02300b1
Autor:
Louise Pham, David K. Wright, William T. O'Brien, Jesse Bain, Cheng Huang, Mujun Sun, Pablo M. Casillas-Espinosa, Anup D. Shah, Ralf B. Schittenhelm, Christopher G. Sobey, Rhys D. Brady, Terence J. O'Brien, Richelle Mychasiuk, Sandy R. Shultz, Stuart J. McDonald
Publikováno v:
Neurobiology of Disease, Vol 148, Iss , Pp 105151- (2021)
A history of mild traumatic brain injury (mTBI) is linked to a number of chronic neurological conditions, however there is still much unknown about the underlying mechanisms. To provide new insights, this study used a clinically relevant model of rep
Externí odkaz:
https://doaj.org/article/0242553506df4e8a87f3334e2abe75b1
Autor:
Andre Mu, William P. Klare, Sarah L. Baines, C. N. Ignatius Pang, Romain Guérillot, Nichaela Harbison-Price, Nadia Keller, Jonathan Wilksch, Nguyen Thi Khanh Nhu, Minh-Duy Phan, Bernhard Keller, Brunda Nijagal, Dedreia Tull, Saravanan Dayalan, Hwa Huat Charlie Chua, Dominik Skoneczny, Jason Koval, Abderrahman Hachani, Anup D. Shah, Nitika Neha, Snehal Jadhav, Sally R. Partridge, Amanda J. Cork, Kate Peters, Olivia Bertolla, Stephan Brouwer, Steven J. Hancock, Laura Álvarez-Fraga, David M. P. De Oliveira, Brian Forde, Ashleigh Dale, Warasinee Mujchariyakul, Calum J. Walsh, Ian Monk, Anna Fitzgerald, Mabel Lum, Carolina Correa-Ospina, Piklu Roy Chowdhury, Robert G. Parton, James De Voss, James Beckett, Francois Monty, Jessica McKinnon, Xiaomin Song, John R. Stephen, Marie Everest, Matt I. Bellgard, Matthew Tinning, Michael Leeming, Dianna Hocking, Leila Jebeli, Nancy Wang, Nouri Ben Zakour, Serhat A. Yasar, Stefano Vecchiarelli, Tonia Russell, Thiri Zaw, Tyrone Chen, Don Teng, Zena Kassir, Trevor Lithgow, Adam Jenney, Jason N. Cole, Victor Nizet, Tania C. Sorrell, Anton Y. Peleg, David L. Paterson, Scott A. Beatson, Jemma Wu, Mark P. Molloy, Anna E. Syme, Robert J. A. Goode, Adam A. Hunter, Grahame Bowland, Nicholas P. West, Marc R. Wilkins, Steven P. Djordjevic, Mark R. Davies, Torsten Seemann, Benjamin P. Howden, Dana Pascovici, Sonika Tyagi, Ralf B. Schittenhelm, David P. De Souza, Malcolm J. McConville, Jonathan R. Iredell, Stuart J. Cordwell, Richard A. Strugnell, Timothy P. Stinear, Mark A. Schembri, Mark J. Walker
Publikováno v:
Nature Communications. 14
Even in the setting of optimal resuscitation in high-income countries severe sepsis and septic shock have a mortality of 20–40%, with antibiotic resistance dramatically increasing this mortality risk. To develop a reference dataset enabling the ide
Autor:
Sandy R. Shultz, Anup D. Shah, Cheng Huang, Larissa K. Dill, Ralf B. Schittenhelm, M. Cristina Morganti-Kossmann, Bridgette D. Semple
Publikováno v:
Journal of Neuroinflammation. 19
The pathophysiology of traumatic brain injury (TBI) requires further characterization to fully elucidate changes in molecular pathways. Cerebrospinal fluid (CSF) provides a rich repository of brain-associated proteins. In this retrospective observati
Autor:
Pablo M Casillas-Espinosa, Alison Anderson, Anna Harutyunyan, Crystal Li, Jiyoon Lee, Emma L Braine, Rhys D Brady, Mujun Sun, Cheng Huang, Christopher K Barlow, Anup D Shah, Ralf B Schittenhelm, Richelle Mychasiuk, Nigel C Jones, Sandy R Shultz, Terence J O'Brien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99b99a69b8fef6867aab95837e9130f6
https://doi.org/10.7554/elife.78877.sa2
https://doi.org/10.7554/elife.78877.sa2
Autor:
Alon M Douek, Abbas Salavaty, Florian Kreuder, Sebastian-Alexander Stamatis, Joel R Steele, Iresha Hanchapola, Anup D Shah, Ralf B Schittenhelm, Mirana Ramialison, Peter D Currie, Jan Kaslin
Mucopolysaccharidoses are lysosomal storage diseases that collectively represent a major cause of lethal, treatment-refractory childhood dementias 1–7 Clinically-useful interventions are hampered due to an incomplete understanding of their neuropat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f6830f198a248d2772208598c3f9520
https://doi.org/10.1101/2022.10.03.510585
https://doi.org/10.1101/2022.10.03.510585
Autor:
Macsue Jacques, Shanie Landen, Javier Alvarez Romero, Danielle Hiam, Ralf B. Schittenhelm, Iresha Hanchapola, Anup D. Shah, Nir Eynon
ObjectiveExercise is a major regulator of muscle metabolism, and health benefits acquired by exercise are a result of molecular shifts occurring across multiple OMIC levels (i.e. epigenome, transcriptome, proteome). Identifying robust targets associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5182c91928d387475f76e75de3a602c
https://doi.org/10.1101/2022.07.11.499662
https://doi.org/10.1101/2022.07.11.499662
Autor:
Pablo M Casillas-Espinosa, Alison Anderson, Anna Harutyunyan, Crystal Li, Jiyoon Lee, Emma L Braine, Rhys D Brady, Mujun Sun, Cheng Huang, Christopher K Barlow, Anup D Shah, Ralf B Schittenhelm, Richelle Mychasiuk, Nigel C Jones, Sandy R Shultz, Terence J O'Brien
There are no pharmacological disease-modifying treatments with an enduring effect to mitigate the seizures and comorbidities of established chronic temporal lobe epilepsy (TLE). This study aimed to evaluate for disease modifying effects of sodium sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb3eb3799b40df2dd64169ff98287da
https://doi.org/10.1101/2022.05.17.492323
https://doi.org/10.1101/2022.05.17.492323
Autor:
Yijun Pan, Yoshiteru Kagawa, Jiaqi Sun, Bradley J. Turner, Cheng Huang, Anup D. Shah, Ralf B. Schittenhelm, Joseph A. Nicolazzo
Publikováno v:
Pharmaceutics; Volume 14; Issue 12; Pages: 2803
For peripherally administered drugs to reach the central nervous system (CNS) and treat amyotrophic lateral sclerosis (ALS), they must cross the blood–brain barrier (BBB). As mounting evidence suggests that the ultrastructure of the BBB is altered