Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Anup Bhusal"'
Autor:
Anup Bhusal, Kyoungho Suk
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103219- (2024)
Summary: The blood-brain barrier hinders drug delivery to the central nervous system (CNS), particularly for large molecules. Here, we present a protocol for delivering proteins, peptides, and short hairpin RNAs (shRNAs) via the intrathecal (IT) rout
Externí odkaz:
https://doaj.org/article/1ad03f8bab074264a1d599a571ae5552
Autor:
Anup Bhusal, Jae-Hong Kim, Seung-Chan Kim, Eun Mi Hwang, Hoon Ryu, Md. Sekendar Ali, Seung-Chun Park, Won-Ha Lee, Kyoungho Suk
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113813- (2024)
Summary: Peptidoglycan recognition protein 1 (PGLYRP1) is a pattern-recognition protein that mediates antibacterial actions and innate immune responses. Its expression and role in neuroinflammatory conditions remain unclear. We observed the upregulat
Externí odkaz:
https://doaj.org/article/77f0b69a857743ef8a5ae0810ddf5ed5
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S216- (2023)
Externí odkaz:
https://doaj.org/article/ea11ff9d4afa4e409a5bc8ac15e2e68a
Autor:
Francesca Sciarretta, Veronica Ceci, Marta Tiberi, Fabio Zaccaria, Haoyun Li, Zhong-Yan Zhou, Qiyang Sun, Daniels Konja, Alessandro Matteocci, Anup Bhusal, Martina Verri, Diego Fresegna, Sara Balletta, Andrea Ninni, Claudia Di Biagio, Marco Rosina, Kyoungho Suk, Diego Centonze, Yu Wang, Valerio Chiurchiù, Katia Aquilano, Daniele Lettieri-Barbato
Publikováno v:
Molecular Metabolism, Vol 76, Iss , Pp 101783- (2023)
Objective: Accumulating evidence suggests that dysfunctional adipose tissue (AT) plays a major role in the risk of developing multiple sclerosis (MS), the most common immune-mediated and demyelinating disease of the central nervous system. However, t
Externí odkaz:
https://doaj.org/article/773476dec45d4371b40347909e199e36
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Externí odkaz:
https://doaj.org/article/218199bdbe57480bbbadade3bf35254c
Publikováno v:
Cells, Vol 12, Iss 13, p 1750 (2023)
It is now well established that glial cells play an equal, if not greater, role in regulating intricate functions of the central nervous system (CNS) compared with neurons [...]
Externí odkaz:
https://doaj.org/article/279c5e3761674faca00abbb4041597da
Autor:
Md Habibur Rahman, Anup Bhusal, Jae-Hong Kim, Mithilesh Kumar Jha, Gyun Jee Song, Younghoon Go, Il-Sung Jang, In-Kyu Lee, Kyoungho Suk
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Hypothalamic inflammation is involved in the pathogenesis of diabetes. The underlying mechanisms are unclear. Here, the authors show that astrocytic PDK2 ablation or inhibition attenuates hypothalamic inflammation in mouse models of diabetes.
Externí odkaz:
https://doaj.org/article/ab0aa5b82f814602985d6ffd3a2191a4
Autor:
Jae-Hong Kim, Osung Kwon, Anup Bhusal, Jiyoun Lee, Eun Mi Hwang, Hoon Ryu, Jae-Yong Park, Kyoungho Suk
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Transgenic mice are a useful tool for exploring various aspects of gene function. A key element of this approach is the targeted overexpression of specific genes in cells or tissues. Herein, we report for the first time, the generation and characteri
Externí odkaz:
https://doaj.org/article/31d17ddda9864379a19e10a5509ad342
Publikováno v:
Cells, Vol 11, Iss 23, p 3886 (2022)
Recent studies have suggested that mouse cathelicidin-related antimicrobial peptide (CRAMP) and its human homologue leucine leucine-37 (LL-37) play critical roles in innate immune responses. Here, we studied the role of mouse CRAMP in bacterial endot
Externí odkaz:
https://doaj.org/article/13709bd6e174478793654f1cc22d5330
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Lipocalin-2 (LCN2) is a 25 kDa secreted protein that belongs to the family of lipocalins, a group of transporters of small hydrophobic molecules such as iron, fatty acids, steroids, and lipopolysaccharide in circulation. LCN2 was previously found to
Externí odkaz:
https://doaj.org/article/cd65e1e903674d54a106c56f043aec42