Acute Colon Inflammation Triggers Primary Motor Cortex Glial Activation, Neuroinflammation, Neuronal Hyperexcitability, and Motor Coordination Deficits

Autor: Livia Carrascal, María D. Vázquez-Carretero, Pablo García-Miranda, Ángela Fontán-Lozano, María L. Calonge, Anunciación A. Ilundáin, Carmen Castro, Pedro Nunez-Abades, María J. Peral

Publikováno v: idUS. Depósito de Investigación de la Universidad de Sevilla
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International Journal of Molecular Sciences; Volume 23; Issue 10; Pages: 5347

Neuroinflammation underlies neurodegenerative diseases. Herein, we test whether acute colon inflammation activates microglia and astrocytes, induces neuroinflammation, disturbs neuron intrinsic electrical properties in the primary motor cortex, and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc701dd605c9372e6d60e3cefe0d18db
https://doi.org/10.3390/ijms23105347

Reelin-Dab1 signaling system in human colorectal cancer

Autor: María D. Vázquez-Carretero, Anunciación A. Ilundáin, Pablo García-Miranda, José Manuel Serrano-Morales, M.J. Peral

Publikováno v: Molecular Carcinogenesis. 56:712-721

Reelin is an extracellular matrix protein that plays a critical role in neuronal migration. Here we show that the mucosa of human colon expresses reelin, its receptors ApoER2 and VLDLR, and its effector protein Dab1. Immunohistochemical analyses reve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68c7a90767c05ddbe553b86c5819fcdc
https://doi.org/10.1002/mc.22527

Reelin protects from colon pathology by maintaining the intestinal barrier integrity and repressing tumorigenic genes

Autor: María D. Vázquez-Carretero, José Manuel Serrano-Morales, Ana E. Carvajal, M.J. Peral, M. L. Calonge, Anunciación A. Ilundáin, Pablo García-Miranda

Publikováno v: idUS. Depósito de Investigación de la Universidad de Sevilla
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We previously reported that reelin, an extracellular matrix protein first known for its key role in neuronal migration, reduces the susceptibility to dextran sulphate sodium (DSS)-colitis. The aim of the current study was to determine whether reelin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a39ea2e2a53f75e8f8593f59d49d783
https://pubmed.ncbi.nlm.nih.gov/28572005

Dab1 and reelin participate in a common signal pathway that controls intestinal crypt/villus unit dynamics

Autor: M.J. Peral, M. L. Calonge, María D. Vázquez-Carretero, Anunciación A. Ilundáin, Pablo García-Miranda

Publikováno v: Biology of the Cell. 106:83-96

Background information The myofibroblasts placed underneath the epithelium of the rodent small intestine express reelin, and the reelin absence modifies both the morphology and the cell renewal processes of the crypt–villus unit. In the developing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a0d28f65c3d7be5d95229b9f5a980ea
https://doi.org/10.1111/boc.201300078

The Synaptojanins in the murine small and large intestine

Autor: María D. Vázquez-Carretero, José Manuel Serrano-Morales, M.J. Peral, Anunciación A. Ilundáin, Pablo García-Miranda, Ana E. Carvajal

Publikováno v: Journal of bioenergetics and biomembranes. 48(6)

The expression of the phosphoinositides phosphatases Synaptojanins (Synjs) 1 and 2 has been shown in brain and in some peripheral tissues, but their expression in the intestine has not been reported. Herein we show that the small and large intestine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e154ed20b0d9ce203144b6a66fa111c8
https://pubmed.ncbi.nlm.nih.gov/27878645