Discovery of nonbenzamidine factor VIIa inhibitors using a biaryl acid scaffold

Autor: Bolton, Scott A., Sutton, James C., Anumula, Rushith, Bisacchi, Gregory S., Jacobson, Bruce, Slusarchyk, William A., Treuner, Uwe D., Wu, Shung C., Zhao, Guohua, Pi, Zulan, Sheriff, Steven, Smirk, Rebecca A., Bisaha, Sharon, Cheney, Daniel L., Wei, Anzhi, Schumacher, William A., Hartl, Karen S., Liu, Eddie, Zahler, Robert, Seiler, Steven M.

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 15 September 2013 23(18):5239-5243

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Design and Synthesis of Phenylpyrrolidine Phenylglycinamides As Highly Potent and Selective TF-FVIIa Inhibitors.

Autor: Zhang X; Bristol-Myers Squibb R&D , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534-2130, United States., Jiang W; Bristol-Myers Squibb R&D , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534-2130, United States., Jacutin-Porte S; Bristol-Myers Squibb R&D , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534-2130, United States., Glunz PW; Bristol-Myers Squibb R&D , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534-2130, United States., Zou Y; Bristol-Myers Squibb R&D , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534-2130, United States., Cheng X; Bristol-Myers Squibb R&D , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534-2130, United States., Nirschl AH; Bristol-Myers Squibb R&D , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534-2130, United States., Wurtz NR; Bristol-Myers Squibb R&D , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534-2130, United States., Luettgen JM; Bristol-Myers Squibb R&D , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534-2130, United States., Rendina AR; Bristol-Myers Squibb R&D , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534-2130, United States., Luo G; Bristol-Myers Squibb R&D , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534-2130, United States., Harper TM; Bristol-Myers Squibb R&D , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534-2130, United States., Wei A; Bristol-Myers Squibb R&D , US Route 206 & Province Line Road, Princeton, New Jersey 08543-4000, United States., Anumula R; Biocon BMS R&D Center (BBRC), Syngene International Ltd. , Plot No. 2 & 3, Bommasandra IV Phase, Jigani Link Road, Bangalore 560 099, India., Cheney DL; Bristol-Myers Squibb R&D , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534-2130, United States., Knabb RM; Bristol-Myers Squibb R&D , US Route 206 & Province Line Road, Princeton, New Jersey 08543-4000, United States., Wong PC; Bristol-Myers Squibb R&D , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534-2130, United States., Wexler RR; Bristol-Myers Squibb R&D , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534-2130, United States., Priestley ES; Bristol-Myers Squibb R&D , 311 Pennington-Rocky Hill Road, Pennington, New Jersey 08534-2130, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2013 Dec 26; Vol. 5 (2), pp. 188-92. Date of Electronic Publication: 2013 Dec 26 (Print Publication: 2014).