Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Anujaianthi Kuzhandaivel"'
Autor:
Gonzalo M. Sanchez, Liza Alkhori, Eduardo Hatano, Sebastian W. Schultz, Anujaianthi Kuzhandaivel, Shadi Jafari, Björn Granseth, Mattias Alenius
Publikováno v:
Cell Reports, Vol 14, Iss 3, Pp 464-470 (2016)
Hedgehog (Hh) signaling is a key regulatory pathway during development and also has a functional role in mature neurons. Here, we show that Hh signaling regulates the odor response in adult Drosophila olfactory sensory neurons (OSNs). We demonstrate
Externí odkaz:
https://doaj.org/article/e4e6bb1f785f4efcbd4deae39849de23
Publikováno v:
Cell Reports, Vol 7, Iss 3, Pp 672-680 (2014)
Cilia mediate Hedgehog (Hh) signaling in vertebrates and Hh deregulation results in several clinical manifestations, such as obesity, cognitive disabilities, developmental malformations, and various cancers. Drosophila cells are nonciliated during de
Externí odkaz:
https://doaj.org/article/56f1858b0f214a1d88165067fd95be0d
Publikováno v:
European Journal of Neuroscience. 33:2216-2227
Delayed neuronal destruction after acute spinal injury is attributed to excitotoxicity mediated by hyperactivation of poly(ADP-ribose) polymerase-1 (PARP-1) that induces ‘parthanatos’, namely a non-apoptotic cell death mechanism. With an in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cd6cb102e7c6bcc0bbf7e46cbe9c96f
https://doi.org/10.1111/j.1460-9568.2011.07714.x
https://doi.org/10.1111/j.1460-9568.2011.07714.x
Autor:
Anujaianthi Kuzhandaivel, Miranda Mladinic, Gayane Margaryan, Giuliano Taccola, Andrea Nistri
Publikováno v:
Annals of the New York Academy of Sciences. 1198:242-251
Although spinal injury is a major cause of chronic disability, the mechanisms responsible for the lesion pathophysiology and their dynamic evolution remain poorly understood. Hence, current treatments aimed at blocking damage extension are unsatisfac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1feee20a3c23240856d94ffd4b5c51ee
https://doi.org/10.1111/j.1749-6632.2009.05427.x
https://doi.org/10.1111/j.1749-6632.2009.05427.x
Publikováno v:
Cell Reports, Vol 7, Iss 3, Pp 672-680 (2014)
Cilia mediate Hedgehog (Hh) signaling in vertebrates and Hh deregulation results in several clinical manifestations, such as obesity, cognitive disabilities, developmental malformations, and various cancers. Drosophila cells are nonciliated during de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40b8276e2888380439a9a6029f0e602
https://pubmed.ncbi.nlm.nih.gov/24768000
https://pubmed.ncbi.nlm.nih.gov/24768000
Autor:
Athena Akrami, Marco Milanese, Anujaianthi Kuzhandaivel, Elena Bianchetti, Giambattista Bonanno, Sara Ebrahimi Nasrabady, Andrea Nistri
Overactivity of poly(ADP-ribose) polymerase enzyme 1 (PARP-1) is suggested to be a major contributor to neuronal damage following brain or spinal cord injury, and has led to study the PARP-1 inhibitor 2-(dimethylamino)-N-(5,6-dihydro-6-oxophenanthrid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67038e1e4ab891399d388a97384bdc87
http://hdl.handle.net/20.500.11767/14908
http://hdl.handle.net/20.500.11767/14908
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 5 (2011)
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience
Understanding the pathophysiological changes triggered by an acute spinal cord injury is a primary goal to prevent and treat chronic disability with a mechanism-based approach. After the primary phase of rapid cell death at the injury site, secondary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18da6bcd4fc378f86265b522605f3e1d
http://journal.frontiersin.org/Journal/10.3389/fncel.2011.00009/full
http://journal.frontiersin.org/Journal/10.3389/fncel.2011.00009/full
Excitotoxicity is considered to be a major pathophysiological mechanism responsible for extensive neuronal death after acute spinal injury. The chief effector of such a neuronal death is thought to be the hyperactivation of intracellular PARP-1 that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63b455f9811110c09ab1c4ab268e9bc
http://hdl.handle.net/20.500.11767/14625
http://hdl.handle.net/20.500.11767/14625
Publikováno v:
Neuroscience. 169(1)
The current etiopathogenesis of spinal cord injury comprises a growing number of nontraumatic causes, including ischemia generating hypoxic-dysmetabolic conditions. To mimic the metabolic disruption accompanying nontraumatic acute spinal cord injury
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191827891baa32190296c20e8f558a74
https://pubmed.ncbi.nlm.nih.gov/20466038
https://pubmed.ncbi.nlm.nih.gov/20466038