Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Anuj Khandelwal"'
Autor:
Anuj Khandelwal, Caitlin N. Kent, Maurie Balch, Shuxia Peng, Sanket J. Mishra, Junpeng Deng, Victor W. Day, Weiya Liu, Chitra Subramanian, Mark Cohen, Jeffery M. Holzbeierlein, Robert Matts, Brian S. J. Blagg
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
The molecular chaperone Hsp90 oversees the folding of many proteins associated with cancer progression but existing small-molecule inhibitors of this pathway are not isoform-selective. Here, the authors rationally design an Hsp90 inhibitor that displ
Externí odkaz:
https://doaj.org/article/22d6d57dbf0548efa5ef84106a4676a4
Autor:
Alice Sheehan, Andrew E. Messer, Maria Papadaki, Afnan Choudhry, Vladimír Kren, David Biedermann, Brian Blagg, Anuj Khandelwal, Steven B. Marston
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
The inherited cardiomyopathies, hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) are relatively common, potentially life-threatening and currently untreatable. Mutations are often in the contractile proteins of cardiac muscle and ca
Externí odkaz:
https://doaj.org/article/9f4cc4a1c9ae44e7b2ed21de81cc6c4f
Publikováno v:
Indian Journal of Psychological Medicine, Vol 38, Iss 4, Pp 361-363 (2016)
Genital self-mutilation (GSM) is a much rare finding and more commonly associated with psychosis when it comes to comparison with self-mutilation as a whole. There have been anecdotal case reports of GSM in psychotic disorders with most of them being
Externí odkaz:
https://doaj.org/article/04a531c8d0c64bea821a03019879b9e4
Autor:
Agnieszka Lewandowska, Corinne P. Soutar, Alexander I. Greenwood, Evgeny Nimerovsky, Ashley M. De Lio, Jordan T. Holler, Grant S. Hisao, Anuj Khandelwal, Jiabao Zhang, Anna M. SantaMaria, Charles D. Schwieters, Taras V. Pogorelov, Martin D. Burke, Chad M. Rienstra
Publikováno v:
Nat Struct Mol Biol
Amphotericin B (AmB) is a powerful but toxic fungicide that operates via enigmatic small molecule–small molecule interactions. This mechanism has challenged the frontiers of structural biology for half a century. We recently showed AmB primarily fo
Publikováno v:
2021 International Conference on Artificial Intelligence and Machine Vision (AIMV).
Autor:
Jocelyn Trottier, Fereshteh Fani, Martin D. Burke, Philippe Leprohon, Hélène Gingras, Anuj Khandelwal, Angana Mukherjee, Marc Ouellette, Jiabao Zhang, Christelle Morelle, Olivier Barbier
Publikováno v:
ACS infectious diseases. 7(8)
Chemotherapy against the neglected tropical disease visceral leishmaniasis (VL) is suboptimal with only four licensed drugs. Amphotericin B (AmB), despite its toxicity, remained a second line drug for a long time. However, the demonstration that lipo
Autor:
Premanand Ghadekar, Anant Dhok, Sonica Kulkarni, Ayush Tejwani, Anuj Khandelwal, Srivallabh Mangrulkar
Publikováno v:
Communications in Computer and Information Science ISBN: 9789811566332
The healthcare domain is always upgrading itself in order to provide better care. The use of digital media for medical purposes has been on the rise. Naturally, these methods are being used to store and retrieve medical records. These records are wid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::447b0512b8fd821b523d7db8dff7b2a4
https://doi.org/10.1007/978-981-15-6634-9_44
https://doi.org/10.1007/978-981-15-6634-9_44
Autor:
Chitra Subramanian, Robert L. Matts, Brian S. J. Blagg, Anuj Khandelwal, Weiya Liu, Jeffery M. Holzbeierlein, Junpeng Deng, Mark S. Cohen, Victor W. Day, Sanket J. Mishra, Caitlin N. Kent, Maurie Balch, Shuxia Peng
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
Nature Communications
Nature Communications
The 90 kDa heat shock protein (Hsp90) is a molecular chaperone responsible for folding proteins that are directly associated with cancer progression. Consequently, inhibition of the Hsp90 protein folding machinery results in a combinatorial attack on
Publikováno v:
Medicinal Research Reviews. 36:92-118
The 90 kDa heat shock proteins (Hsp90) are responsible for the conformational maturation of nascent polypeptides and the rematuration of denatured proteins. Proteins dependent upon Hsp90 are associated with all six hallmarks of cancer. Upon Hsp90 inh
Publikováno v:
Indian Journal of Psychological Medicine
Indian Journal of Psychological Medicine, Vol 38, Iss 4, Pp 361-363 (2016)
Indian Journal of Psychological Medicine, Vol 38, Iss 4, Pp 361-363 (2016)
Genital self-mutilation (GSM) is a much rare finding and more commonly associated with psychosis when it comes to comparison with self-mutilation as a whole. There have been anecdotal case reports of GSM in psychotic disorders with most of them being