Výsledky vyhledávání - "Anuj K. Kashyap"

Akademický článek

Chlamydia evasion of neutrophil host defense results in NLRP3 dependent myeloid-mediated sterile inflammation through the purinergic P2X7 receptor

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Myeloid cells are implicated in the innate immune and inflammatory response during infection with Chlamydia trachomatis. Here the authors show the evasion of the neutrophil response to infection and concomitant induction of sterile immunity via the p

Externí odkaz: https://doaj.org/article/9b6d6afc6d5a40fdb29b81834b7b8934

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Chlamydia evasion of neutrophil host defense results in NLRP3 dependent myeloid-mediated sterile inflammation through the purinergic P2X7 receptor

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Chlamydia trachomatis infection causes severe inflammatory disease resulting in blindness and infertility. The pathophysiology of these diseases remains elusive but myeloid cell-associated inflammation has been implicated. Here we show NLRP3 inflamma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca5cd91c56c4532f3326cf5fda2394c
https://pubmed.ncbi.nlm.nih.gov/34526512

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Transcriptional Response of Respiratory Epithelium to Nontuberculous Mycobacteria

Autor: John S. Tsang, Steven M. Holland, Juraj Kabat, Adrian M. Zelazny, Masashi Matsuyama, Anuj K. Kashyap, Olena Kamenyeva, Andrew J. Martins, Kenneth N. Olivier, Shamira J. Shallom, Elizabeth P. Sampaio

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 58:241-252

The incidence of pulmonary nontuberculous mycobacteria (NTM) disease is increasing, but host responses in respiratory epithelium infected with NTM are not fully understood. In this work, we aimed to identify infection-relevant gene expression signatu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32cb352471984be824d66e0255c044eb
https://doi.org/10.1165/rcmb.2017-0218oc

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CARD19, the protein formerly known as BinCARD, is a mitochondrial protein that does not regulate Bcl10-dependent NF-κB activation after TCR engagement

Autor: Sean K. Maynard, Kariana E. Rios, Suman Paul, Michael A Washington, Brian C. Schaefer, Anuj K. Kashyap

Publikováno v: Cell Immunol

After T cell receptor (TCR) engagement, the CARD11-Bcl10-Malt1 (CBM) complex oligomerizes to transduce NF-κB activating signals. Bcl10 is then degraded to limit NF-κB activation. The cDNA AK057716 (BinCARD-1) was reported to encode a novel CARD pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e00b8050e703ac467078e397670da3
https://doi.org/10.1016/j.cellimm.2020.104179

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Effective 'activated PI3Kδ syndrome'–targeted therapy with the PI3Kδ inhibitor leniolisib

Publikováno v: Blood, 130(21), 2307-2316. American Society of Hematology

Pathogenic gain-of-function variants in the genes encoding phosphoinositide 3-kinase δ (PI3Kδ) lead to accumulation of transitional B cells and senescent T cells, lymphadenopathy, and immune deficiency (activated PI3Kδ syndrome [APDS]). Knowing th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ee11d7e47890c9ff26ab300ee6042f
https://europepmc.org/articles/PMC5701526/

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Selective Autophagy of the Adaptor Protein Bcl10 Modulates T Cell Receptor Activation of NF-κB

Autor: Anuj K. Kashyap, You-Wen He, Suman Paul, Wei Jia, Brian C. Schaefer

Publikováno v: Immunity. 36(6):947-958

SummaryThe adaptor protein Bcl10 is a critically important mediator of T cell receptor (TCR)-to-NF-κB signaling. Bcl10 degradation is a poorly understood biological phenomenon suggested to reduce TCR activation of NF-κB. Here we have shown that TCR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6560a45e6aeebef446a9d3f49ae535

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An active kinase domain is required for retention of PKCθ at the T cell immunological synapse

Autor: Brian C. Schaefer, Natalia G. Cartwright, Anuj K. Kashyap

Publikováno v: Molecular Biology of the Cell

In response to antigen stimulation, PKCθ translocates to the T cell plasma membrane, becoming highly focused at the immunological synapse (IS). cis-Acting sequences that regulate IS retention are not known. It is shown that a catalytically competent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835b491ce62f736ed6dd1126fa999249
http://europepmc.org/articles/PMC3172272

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Novel signal transducer and activator of transcription 1 mutation disrupts small ubiquitin-related modifier conjugation causing gain of function

Autor: Elizabeth P. Sampaio, Phillip Cruz, Tatyana A. Tavella, Anuj K. Kashyap, Michail S. Lionakis, Stacey R. Rose, Amy P. Hsu, Lindsey B. Rosen, Christa S. Zerbe, Elise M. N. Ferré, Steven M. Holland, Meredith K. Wierman, Margery G. Smelkinson, Li Ding

Publikováno v: Journal of Allergy and Clinical Immunology. 141:1844-1853.e2

Background Sumoylation is a posttranslational reversible modification of cellular proteins through the conjugation of small ubiquitin-related modifier (SUMO) and comprises an important regulator of protein function. Objective We sought to characteriz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d80507d8ac830fc9ac372ebba732008
https://doi.org/10.1016/j.jaci.2017.07.027

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T Cell Receptor Signals to NF-κB Are Transmitted by a Cytosolic p62-Bcl10-Malt1-IKK Signalosome

Autor: Brian C. Schaefer, Maria Traver, Suman Paul, Michael A Washington, Joseph R. Latoche, Anuj K. Kashyap

Publikováno v: Science Signaling. 7

Antigen-mediated stimulation of the T cell receptor (TCR) triggers activation of nuclear factor κB (NF-κB), a key transcriptional regulator of T cell proliferation and effector cell differentiation. TCR signaling to NF-κB requires both the Carma1-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77fb27197dbab1f57e18cf36f1aa1508
https://doi.org/10.1126/scisignal.2004882

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Multiple Protein Domains Mediate Interaction between Bcl10 and MALT1*

Autor: Anuj K. Kashyap, Jeremy S. Rossman, Nidhi A. Jain, Lara M. Kingeter, Brian C. Schaefer, Felicia D. Langel

Bcl10 and MALT1 are essential mediators of NF-κB activation in response to the triggering of a diverse array of transmembrane receptors, including antigen receptors. Additionally, both proteins are translocation targets in MALT lymphoma. Thus, a det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca125f73eac6635fa6c05058ac5d87e
https://europepmc.org/articles/PMC2583291/

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