Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Anu Toropainen"'
Autor:
Andrey Anisimov, Shentong Fang, Karthik Amudhala Hemanthakumar, Tiit Örd, Kristof van Avondt, Raphael Chevre, Anu Toropainen, Prosanta Singha, Huda Gilani, Su D. Nguyen, Sinem Karaman, Emilia A. Korhonen, Ralf H. Adams, Hellmut G. Augustin, Katariina Öörni, Oliver Soehnlein, Minna U. Kaikkonen, Kari Alitalo
Publikováno v:
Nature Cardiovascular Research. 2:307-321
Leukocytes and resident cells in the arterial wall contribute to atherosclerosis, especially at sites of disturbed blood flow. Expression of endothelial Tie1 receptor tyrosine kinase is enhanced at these sites, and attenuation of its expression reduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa11707359131185bee4b27b0aa7ffc
https://doi.org/10.1038/s44161-023-00224-y
https://doi.org/10.1038/s44161-023-00224-y
Autor:
Ilakya Selvarajan, Jin Li, Petri Pölönen, Tiit Örd, Kadri Õunap, Aarthi Ravindran, Kiira Mäklin, Anu Toropainen, Lindsey K. Stolze, Stephen White, Casey E. Romanoski, Merja Heinäniemi, Yun Fang, Minna Kaikkonen-Määttä
Coronary artery disease (CAD) is one of the major causes of mortality worldwide. Recent genome-wide association studies have started to unravel the genetic architecture of the disease. Such efforts have identified Calcitonin receptor-like (CALCRL), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e151be10fc3938e1c28e80d8eaa4bb9
https://doi.org/10.1101/2023.02.08.527795
https://doi.org/10.1101/2023.02.08.527795
Autor:
Johanna P. Laakkonen, Henri Niskanen, Lari Holappa, Jari P. Lappalainen, Seppo Ylä-Herttuala, H. H. Pulkkinen, Minna U. Kaikkonen, Mustafa Beter, M. Kiema, Annakaisa Tirronen, Anu Toropainen
Publikováno v:
Angiogenesis
The BMP/TGFβ-Smad, Notch and VEGF signaling guides formation of endothelial tip and stalk cells. However, the crosstalk of bone morphogenetic proteins (BMPs) and vascular endothelial growth factor receptor 2 (VEGFR2) signaling has remained largely u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977f91e013549ed6b56892cd19c3e8a5
http://europepmc.org/articles/PMC7921060
http://europepmc.org/articles/PMC7921060
Autor:
Lindsey K Stolze, Anu Toropainen, Tiit Ord, Michael B Whalen, Minna Kaikkonen, Casey E Romanoski
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 41
Genome-wide association studies have linked thousands of genetic variants with complex diseases and traits. However, most genetic variants identified reside in non-coding regions of the genome, including variants associated with a myriad of vascular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71900c6d1becf2b88a7c5d67fb7fe2bb
https://doi.org/10.1161/atvb.41.suppl_1.104
https://doi.org/10.1161/atvb.41.suppl_1.104
Autor:
Paula Marta Torrell, Verena M. Link, Casey E. Romanoski, Michael B. Whalen, Anu Toropainen, Tiit Örd, Lindsey K. Stolze, Minna U. Kaikkonen
Functional consequences of genetic variation in the non-coding human genome are difficult to ascertain despite demonstrated associations to common, complex disease traits. To elucidate properties of functional non-coding SNPs with effects in human en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92ec812394d36d984ff595f988bb9372
https://doi.org/10.1101/2021.08.03.454513
https://doi.org/10.1101/2021.08.03.454513
Autor:
Anu Toropainen, Lindsey K. Stolze, Tiit Örd, Michael B. Whalen, Paula Martí Torrell, Verena M. Link, Minna U. Kaikkonen, Casey E. Romanoski
Publikováno v:
Genome research. 32(3)
Functional consequences of genetic variation in the noncoding human genome are difficult to ascertain despite demonstrated associations to common, complex disease traits. To elucidate properties of functional noncoding SNPs with effects in human endo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2824748e46b0a21979dba99ca9cc82d0
https://pubmed.ncbi.nlm.nih.gov/35193936
https://pubmed.ncbi.nlm.nih.gov/35193936
Autor:
Lindsey K. Stolze, Elamaran Meibalan, Juho Jalkanen, Minna U. Kaikkonen, Lei Hou, Pasi Tavi, Leandro Z. Agudelo, Tiit Örd, Manolis Kellis, Casey E. Romanoski, S. Linna-Kuosmanen, Jarmo Gunn, Anu Toropainen, Mantero Jc, Galani K, Guillermo García-Cardeña, Renfro A, Calum A. MacRae, E. Schmauch, Carles Boix, Ojanen J, Maija Hollmén, Tuomas Kiviniemi
Ischemic heart disease is the single most common cause of death worldwide with an annual death rate of over 9 million people. Genome-wide association studies have uncovered over 200 genetic loci underlying the disease, providing a deeper understandin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6cca2d8cc683661bf76311024e01800
https://doi.org/10.1101/2021.06.23.449672
https://doi.org/10.1101/2021.06.23.449672
Autor:
Anu Toropainen, Sami Heikkinen, Anna-Liisa Levonen, Ville Männistö, Jussi Pihlajamäki, Dorota Kaminska, Maykel López Rodríguez, Päivi Pajukanta, Tiit Örd, Casey E. Romanoski, Kristina M. Garske, Ashik Jawahar Deen, Minna U. Kaikkonen, Zong Miao, Aldons J. Lusis, Ilakya Selvarajan, Arthur Ko, Kadri Õunap, Oscar Hsin-Fu Liu, Calvin Pan, Pierre Moreau, Aarthi Ravindran
Publikováno v:
Am J Hum Genet
The American Journal of Human Genetics
The American Journal of Human Genetics
Genetic factors underlying coronary artery disease (CAD) have been widely studied using genome-wide association studies (GWASs). However, the functional understanding of the CAD loci has been limited by the fact that a majority of GWAS variants are l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79be5c2294d70f87f28cfc9b023ad559
https://europepmc.org/articles/PMC8008493/
https://europepmc.org/articles/PMC8008493/
Autor:
V. Nurminen, Minna U. Kaikkonen, Lindsey K. Stolze, Einari Aavik, T. Örd, K. Õunap, Casey E. Romanoski, Anu Toropainen, R. Aherrahrou, Seppo Ylä-Herttuala, M. Civelek
Publikováno v:
Atherosclerosis. 331:e17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::533c4855afaf443dbee88e7c89fe3b25
https://doi.org/10.1016/j.atherosclerosis.2021.06.055
https://doi.org/10.1016/j.atherosclerosis.2021.06.055
Autor:
Einari Aavik, Casey E. Romanoski, Seppo Ylä-Herttuala, Ilakya Selvarajan, Valtteri Nurminen, Redouane Aherrahrou, Kadri Õunap, Anu Toropainen, Minna U. Kaikkonen, Mete Civelek, Tiit Örd, Tapio Lönnberg, Lindsey K. Stolze
Publikováno v:
Circulation Research
Rationale: Genome-wide association studies have identified hundreds of loci associated with coronary artery disease (CAD). Many of these loci are enriched in cisregulatory elements but not linked to cardiometabolic risk factors nor to candidate causa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5853fc5221283398add4d961aed488