Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Anu Rambhadran"'
Autor:
Avanish K Varshney, Galina A Kuzmicheva, Jian Lin, Kevin M Sunley, Rodney A Bowling, Tzu-Yu Kwan, Heather R Mays, Anu Rambhadran, Yanfeng Zhang, Rebecca L Martin, Michael C Cavalier, John Simard, Sushma Shivaswamy
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190537 (2018)
Staphylococcus aureus can cause devastating and life-threatening infections. With the increase in multidrug resistant strains, novel therapies are needed. Limited success with active and passive immunization strategies have been attributed to S. aure
Externí odkaz:
https://doaj.org/article/cee8b261e24848b49ea2d2c8f81fb79b
Autor:
David M. MacLean, David Cooper, Christy F. Landes, Vasanthi Jayaraman, Nitesh Kumar Poddar, Swarna S. Ramaswamy, J. Nick Taylor, Anu Rambhadran, Heui Uhm
Publikováno v:
Journal of Biological Chemistry. 287:43557-43564
We have investigated the range of cleft closure conformational states that the agonist-binding domains of the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors occupy when bound to a series of willardiine derivatives using single
Publikováno v:
Nature chemical biology
α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors mediate fast excitatory neurotransmission by converting chemical signals into electrical signals. Thus, it is important to understand the relationship between their chemical biology
Publikováno v:
Journal of Biological Chemistry. 285:15296-15301
N-Methyl-d-aspartate (NMDA) receptors, the main mediators of excitatory synaptic transmission, are heterotetrameric receptors. Typically, glycine binding NR1 subunits co-assemble with glutamate binding NR2 subunits to form a functional receptor. Here
Autor:
Anu Rambhadran, Rodney A. Bowling, Rebecca L. Martin, Tzu-Yu Kwan, Yanfeng Zhang, Avanish K. Varshney, Kevin M. Sunley, Jian Lin, Sushma Shivaswamy, John Simard, Heather R. Mays, Michael C. Cavalier, Galina A. Kuzmicheva
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190537 (2018)
PLoS ONE
PLoS ONE
Staphylococcus aureus can cause devastating and life-threatening infections. With the increase in multidrug resistant strains, novel therapies are needed. Limited success with active and passive immunization strategies have been attributed to S. aure
Publikováno v:
Protein Science. 18:1585-1591
Fourier transform infrared spectroscopy has been used to probe the agonist-protein interactions in the ligand binding domain of the GluR6 subunit, one subunit of the kainate subtype of glutamate receptors. In order to study the changes in the interac
Publikováno v:
Journal of Biological Chemistry. 283:27074-27078
The apo state structure of the isolated ligand binding domain of the GluR6 subunit and the conformational changes induced by agonist binding to this protein have been investigated by luminescence resonance energy transfer (LRET) measurements. The LRE
Publikováno v:
Biochemistry. 47:10027-10032
The structural investigations using the soluble ligand binding domain of the AMPA subtype of the glutamate receptor have provided invaluable insight into the mechanistic pathway by which agonist binding to this extracellular domain mediates the forma
Publikováno v:
Biochemistry. 47:398-404
Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, one subtype in the family of ionotropic glutamate receptors, are the main receptors responsible for excitatory signaling in the mammalian central nervous system. Previous stud
Publikováno v:
Biochemistry. 46:1343-1349
Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are the main excitatory neurotransmitter receptors in the mammalian central nervous system. Structures of the isolated ligand binding domain of this receptor have provided sign