Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Anu R. Melge"'
Autor:
Bobby D. Robinson, Claire L. Isbell, Anu R. Melge, Angela M. Lomas, Chinchusha Anasooya Shaji, C. Gopi Mohan, Jason H. Huang, Binu Tharakan
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The main objective of this study was to determine the cellular and molecular effects of doxycycline on the blood–brain barrier (BBB) and protection against secondary injuries following traumatic brain injury (TBI). Microvascular hyperperme
Externí odkaz:
https://doaj.org/article/2356e89712b944149e98f1ef54b49734
Publikováno v:
Journal of Advanced Research, Vol 7, Iss 6, Pp 931-944 (2016)
Limited progress has been made in the quest to identify both selective and non-toxic T-type calcium channel blocking compounds. The present research work was directed toward slaking the same by identifying the selective three dimensional (3D) pharmac
Externí odkaz:
https://doaj.org/article/ca421cb7ea55408ca625516cbf13c1c2
Publikováno v:
Journal of Chemical Information and Modeling. 62:1126-1146
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6aee60c84ea4615656de12134ff5fe7b
https://doi.org/10.1021/acs.jcim.1c01554
https://doi.org/10.1021/acs.jcim.1c01554
Autor:
C. Gopi Mohan, Prajeesh Nath En, Anu R. Melge, Anju Choorakottayil Pushkaran, Rammanohar Puthiyedath
Publikováno v:
RSC Advances. 11:12003-12014
Identifying best bioactive phytochemicals from different medicinal plants using molecular docking techniques demonstrates a potential pre-clinical compound discovery against SARS-CoV-2 viral infection. The in silico screening of bioactive phytochemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd0ea5b3b4a0d4731184d0d2af48a19
https://doi.org/10.1039/d0ra10458b
https://doi.org/10.1039/d0ra10458b
Autor:
Anu R. Melge, C Gopi Mohan, K. Manzoor, Lekshmi G. Kumar, Keechilat Pavithran, Shantikumar V. Nair
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 37:4747-4766
BCR-ABL fusion protein drives chronic myeloid leukemia (CML) which constitutively activates tyrosine kinase involved in the initiation and maintenance of CML phenotype. Ponatinib, an oral drug, was discovered as an efficient BCR-ABL inhibitor by addr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fef344506a5c988d54e866215778a009
https://doi.org/10.1080/07391102.2018.1559765
https://doi.org/10.1080/07391102.2018.1559765
Publikováno v:
Journal of pharmaceutical sciences. 110(2)
Epidermal growth factor receptor (EGFR) is a transmembrane druggable target controlling cellular differentiation, proliferation, migration, survival and invasion. EGFR activation mainly occurs by its homo/hetro dimerization molecular phenomenon leadi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5369a5b444f68183dcb7bef7ae4c183
https://pubmed.ncbi.nlm.nih.gov/33058896
https://pubmed.ncbi.nlm.nih.gov/33058896
Autor:
Jerzy Leszczynski, Sunitha Subhramanian, C. Gopi Mohan, C P Anju, Natalia Sizochenko, Anu R. Melge
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 37:1582-1596
The bacterial ribosome is an established target for anti-bacterial therapy since decades. Several inhibitors have already been developed targeting both defined subunits (50S and 30S) of the ribosome. Aminoglycosides and tetracyclines are two classes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219ffc6f6b1e16ade96195ea47504554
https://doi.org/10.1080/07391102.2018.1462731
https://doi.org/10.1080/07391102.2018.1462731
Autor:
C. Gopi Mohan, Abhilash Sasidharan, Shantikumar V. Nair, K Manzoor, Anu R. Melge, Faiza Basheer
Publikováno v:
International Journal of Biological Macromolecules. 110:540-549
Recent reports indicated DNA damaging potential of few-layer graphene in human cell systems. Here, we used computational technique to understand the interaction of both pristine (pG) or carboxyl functionalized graphene (fG) of different sizes (1, 6,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c005909610aa6db33d6ad347810b229
https://doi.org/10.1016/j.ijbiomac.2017.10.106
https://doi.org/10.1016/j.ijbiomac.2017.10.106
Publikováno v:
Chemical Biology & Drug Design. 90:629-636
Present work elucidates identification of next generation inhibitors for clinically relevant mutations of epidermal growth factor receptor (EGFR) using structure-based bioactive pharmacophore modeling followed by virtual screening (VS) techniques. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::787d72413eccea881eca90c0b57bf918
https://doi.org/10.1111/cbdd.12977
https://doi.org/10.1111/cbdd.12977
The drug-repurposing approach has become an attractive area of research in drug-discovery programs due to its concise and rapid drug-development process. Several in silico drug-repurposing strategies have emerged in the current era, enabling rapid pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74e306055844a89c39e4f01356e4095c
https://doi.org/10.1016/b978-0-12-816125-8.00019-5
https://doi.org/10.1016/b978-0-12-816125-8.00019-5
