Imbalance of plasma amino acids, metabolites and lipids in patients with lysinuric protein intolerance (LPI)

Autor: Ismo Mattila, Harri Niinikoski, Maaria Tringham, Olli Simell, Anu Olkku, Johanna Kurko, Heli Nygren, Matej Orešič, Mari Vähä-Mäkilä, Päivi Pöhö, Tuulia Hyötyläinen, Niina Lietzen, Kirsti Näntö-Salonen, Juha Mykkänen, Laura Tanner

Publikováno v: Kurko, J, Tringham, M, Tanner, L, Näntö-Salonen, K, Vähä-Mäkilä, M, Nygren, H, Pöhö, P, Lietzen, N, Mattila, I, Olkku, A, Hyötyläinen, T, Oresic, M, Simell, O, Niinikoski, H & Mykkänen, J 2016, ' Imbalance of plasma amino acids, metabolites and lipids in patients with lysinuric protein intolerance (LPI) ', Metabolism: Clinical and Experimental, vol. 65, no. 9, pp. 1361-1375 . https://doi.org/10.1016/j.metabol.2016.05.012

Background Lysinuric protein intolerance (LPI [MIM 222700]) is an aminoaciduria with defective transport of cationic amino acids in epithelial cells in the small intestine and proximal kidney tubules due to mutations in the SLC7A7 gene. LPI is charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::767423d7e038f346ef2d839e1bb3cae0
https://cris.vtt.fi/en/publications/47676a01-8ad2-47cb-a5ec-e6bdd48bed4f

Dioxins interfere with differentiation of osteoblasts and osteoclasts

Autor: Elise Kallio, Anu Olkku, Merja Korkalainen, Joanna Ilvesaro, Juha Tuukkanen, Matti Viluksela, Katri Nelo, Anitta Mahonen

Publikováno v: Bone. 44:1134-1142

We have previously shown that the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) affects bone growth, modelling and mechanical strength in vivo. In this study, we utilized differentiation of bone marrow stem cells to osteoblasts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b655732eaf3efea0709d00e9ab208332
https://doi.org/10.1016/j.bone.2009.02.019

Genome-wide microarray analysis of MG-63 osteoblastic cells exposed to ultrasound

Autor: Hannu M. Karjalainen, Mikko J. Lammi, Anitta Mahonen, Kullervo Hynynen, Jarkko Leskinen, Anu Olkku

Publikováno v: Biorheology. 45:345-354

It is well documented that low intensity pulsed ultrasound can be clinically used to accelerate bone fracture healing. Additionally, in vitro studies have shown that ultrasound can, for instance, increase mineralization, collagen production and alkal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f1e42058ecbfcd8a0f1f1433c0624d5
https://doi.org/10.3233/bir-2008-0480

Glucocorticoids induce glutamine synthetase expression in human osteoblastic cells: a novel observation in bone

Autor: P.V.N Bodine, Anitta Mahonen, Anu Olkku, A Linnala-Kankkunen

Publikováno v: Bone. 34:320-329

Glucocorticoids have marked effects on bone metabolism, and continued exposure of skeletal tissue to excessive amounts of these steroids results in osteoporosis. Therefore, in the present proteomic study, we characterized the potential effects of glu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4a8f024a449bb9396406e2bf71a58f
https://doi.org/10.1016/j.bone.2003.09.010

Ultrasound Induced Activation of Cell Signaling on Human MG-63 Osteoblastic Cells

Autor: Jarkko Leskinen, Anu Olkku, Mikko J. Lammi, Anitta Mahonen, Kullervo Hynynen, Emad S. Ebbini

Publikováno v: AIP Conference Proceedings.

Activity of Wnt/β‐catenin signaling pathway associated to bone formation and maintenance was studied by exposing human MG‐63 osteoblastic cells to ultrasound or heat.The in vitro US system consisting of three planar PZT26 discs operating at freq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::644a928aab2b21ab3499f3ce4352d296
https://doi.org/10.1063/1.3131448