Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Anu Moilanen"'
Autor:
Johanna K. Ahlskog, Antti Pohjakallio, Ralf Paul, Martin Augustin, Elisabeth Schneider, Sakshi Johri, Tuomas Tervahauta, Hans-Georg Beisel, Lars Neumann, Julia Lindqvist, Anu Moilanen
Publikováno v:
Cancer Research. 83:6179-6179
Background: DNA Polymerase θ (Polθ) is active in Theta-mediated end joining (TMEJ), a repair pathway that utilizes resected 3’ ends and micro-homology sequences to repair double strand breaks. Polθ contains an N-terminal helicase domain and a C-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a398847ea3513ad142d5cc706bdaf5e
https://doi.org/10.1158/1538-7445.am2023-6179
https://doi.org/10.1158/1538-7445.am2023-6179
Autor:
Avainash Kumar, Olli Törmäkangas, Susanta Samajdar, AB Aravind, Suraj Tgore, Subhendu Mukherjee, Nirbhay Kumar Tiwari, Girish Daginakatte, Anu Moilanen, Raghurami B Reddy, Laura Ravanti, Thomas Antony, Elina Mattila, Mari Björkman, Janith Mary Maben, Shekar Chelur, Mahaboobi Jaleel, Nvm Rao Bandaru, Akhila Srinivas, Indu Bansal, DS Samiulla, Rakesh P. Nankar, Kavitha Nellore, Chandrasekhar Abbineni, Chandranath D. Naik, Sanjeev Giri, Murali Ramachandra, Gerd Wohlfahrt, Naveen Kumar, Sivapriya Marappan
Publikováno v:
Cancer Research. 80:1754-1754
Background: Inhibition of Bromodomain and extra-terminal (BET) family proteins by small molecules is actively being pursued as a therapeutic strategy in the clinics. Targeted protein degradation is an emerging therapeutic modality that has shown init
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dac44ba72bb66c0059e6c8a84001aa4d
https://doi.org/10.1158/1538-7445.am2020-1754
https://doi.org/10.1158/1538-7445.am2020-1754
Autor:
Karthikeyan Narasingapuram Arumugam, Jwala Nagaraj, DS Samiulla, Murali Ramachandra, Rajendra K. Palakurthy, Rajeev Goswami, Olli Törmäkangas, Anirudha Lakshminarasimhan, Narasimha Rao Krishnamurthy, Gerd Wohlfahrt, Anu Moilanen, Subhendu Mukherjee, Mahaboobi Jaleel, Anita R. Chacko
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5309-5314
Hepsin, a type II transmembrane serine protease, is upregulated in prostate cancer and known to be involved in the progression of metastasis. Here we report a structure-guided approach, which resulted in the discovery of 2-aryl/pyridin-2-yl-1H-indole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11309c3bb66ab52d9329fa0c0ba4c60
https://doi.org/10.1016/j.bmcl.2015.09.042
https://doi.org/10.1016/j.bmcl.2015.09.042
Autor:
Passiniemi Mikko, Gerd Wohlfahrt, Petteri Rummakko, Reetta Riikonen, Riikka Huhtaniemi, Pekka Kallio, Päivi Taavitsainen, Karjalainen Arja, Chira Malmström, Hanna-Maija Metsänkylä, Meri Ramela, Riikka Oksala, Anu Moilanen, Mika Mustonen
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 192:105115
We report the discovery of a novel nonsteroidal dual-action compound, ODM-204, that holds promise for treating patients with castration-resistant prostate cancer (CRPC), an advanced form of prostate cancer characterised by high androgen receptor (AR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e1dd9dd4e56ddc4b7cbcd89a7b7e4e
https://doi.org/10.1016/j.jsbmb.2018.02.004
https://doi.org/10.1016/j.jsbmb.2018.02.004
Autor:
Heikki Joensuu, Murali Ramachandra, Denis Belitskin, Liina Nevalaita, Päivi Heikkilä, Johanna Englund, Hanna Ala-Hongisto, K Hewitson, Panu E. Kovanen, Shishir M. Pant, Anu Moilanen, Marjut Leidenius, Antti Poso, Harri Sihto, Juha Klefström, Elsa Marques, Topi A. Tervonen
Publikováno v:
Oncogene. 35(14)
Hepsin belongs to a family of cell-surface serine proteases, which have sparked interest as therapeutic targets because of the accessibility of extracellular protease domain for inhibitors. Hepsin is frequently amplified and/or overexpressed in epith
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab30b99eb3488a24b075d14d332ae04a
https://pubmed.ncbi.nlm.nih.gov/26165838
https://pubmed.ncbi.nlm.nih.gov/26165838
Autor:
Krishnaprasad Subbarao, Jwala Nagaraj, Rajendra K. Palakurthy, Ramesh Kumar Sistla, Hosahalli Subramanya, Murali Ramachandra, Chakshusmathi Ghadiyaram, Gerd Wohlfahrt, Narasimha Rao Krishnamurthy, Sreevalsam Gopinath, Anu Moilanen, Subhendu Mukherjee, Pekka Kallio, Tarja Ikonen, Rajeev Goswami, Leena Khare Satyam
Publikováno v:
Bioorganicmedicinal chemistry. 22(12)
Matriptase is a serine protease implicated in cancer invasion and metastasis. Expression of matriptase is frequently dysregulated in human cancers and matriptase has been reported to activate latent growth factors such as hepatocyte growth factor/sca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c843e7bca7b826071bdbe7d7c83e42d
https://pubmed.ncbi.nlm.nih.gov/24794746
https://pubmed.ncbi.nlm.nih.gov/24794746
Autor:
Shekar Chelur, Tim H. Holmström, Kishore Narayan, Murali Ramachandra, Stefan Karlsson, Anu Moilanen, Srinivasan Rajagopalan, Mari Björkman, Raghuveer Ramachandra, Timo Korjamo, Thomas Anthony, Tero Linnanen, DS Samiulla, Gerd Wohlfahrt, Riikka Oksala, Susanta Samajdar, Pekka Kallio
Publikováno v:
Cancer Research. 75:4133-4133
Genomic alterations in fibroblast growth factor receptors (FGFR) and upregulation of vascular endothelial growth factor receptors (VEGFR) are often found in the same cancer types such as gastric, lung and breast and these alterations correlate with p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25482cc8bdaf4ca622d4cd5c20eaf0be
https://doi.org/10.1158/1538-7445.am2015-4133
https://doi.org/10.1158/1538-7445.am2015-4133
Autor:
Jwala Nagaraj, Chakshusmathi Ghadiyaram, Anu Moilanen, Ramesh Kumar Sistla, Murali Ramachandra, Hosahalli Subramanya, Subhendu Mukherjee, Leena Khare Satyam, DS Samiulla, Rajeev Goswami, Beeram Ravi Chandra, Gerd Wohlfahrt
Matriptase belongs to trypsin-like serine proteases involved in matrix remodeling/degradation, growth regulation, survival, motility, and cell morphogenesis. Herein, we report a structure-based approach, which led to the discovery of sulfonamide and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307579e787f4faa4490227606014b2fa
https://europepmc.org/articles/PMC4027570/
https://europepmc.org/articles/PMC4027570/
Publikováno v:
Journal of Biological Chemistry. 271:24151-24156
Cross-modulation between androgen receptor (AR) and NF-kappaB/Rel proteins was studied using various androgen- and NF-kappaB-regulated reporter genes under transient transfection conditions. In COS-1 cells, elevated expression of RelA (p65) repressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf85ecf77b9f59f159cae635ed8b50c
https://doi.org/10.1074/jbc.271.39.24151
https://doi.org/10.1074/jbc.271.39.24151
Autor:
Reetta Riikonen, Pekka Kallio, Riikka Oksala, Chira Malmström, Petteri Rummakko, Anu Moilanen, Mika Mustonen
Publikováno v:
Journal of Clinical Oncology. 34:230-230
230 Background: Castration-resistant prostate cancer (CRPC) is characterized by high androgen receptor (AR) expression and persistent activation of AR signaling axis by residual tissue androgens. Inhibiting AR and androgen biosynthesis together may b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::031d8b96f2e2f39bab5e3ba4c6bb165c
https://doi.org/10.1200/jco.2016.34.2_suppl.230
https://doi.org/10.1200/jco.2016.34.2_suppl.230