Discovery and Clinical Evaluation of MK‐8150, A Novel Nitric Oxide Donor With a Unique Mechanism of Nitric Oxide Release

Autor: Clayton D. Knox, Pieter‐Jan deKam, Karim Azer, Peggy Wong, Antwan G. Ederveen, Diane Shevell, Christopher Morabito, Alan G. Meehan, Wen Liu, Tom Reynders, Jean Francois Denef, Anna Mitselos, Daniel Jonathan, David E. Gutstein, Kaushik Mitra, Shu Yu Sun, Michael Man‐Chu Lo, Doris Cully, Amjad Ali

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 9, Pp n/a-n/a (2016)

Background Nitric oxide donors are widely used to treat cardiovascular disease, but their major limitation is the development of tolerance, a multifactorial process to which the in vivo release of nitric oxide is thought to contribute. Here we descri

Externí odkaz: https://doaj.org/article/7cd174d677244bd59548edc692b1ac0a

Intestinal tumorigenesis is not affected by progesterone signaling in rodent models.

Autor: Jarom Heijmans, Vanesa Muncan, Rutger J Jacobs, Eveline S M de Jonge-Muller, Laura Graven, Izak Biemond, Antwan G Ederveen, Patrick G Groothuis, Sietse Mosselman, James C Hardwick, Daniel W Hommes, Gijs R van den Brink

Publikováno v: PLoS ONE, Vol 6, Iss 7, p e22620 (2011)

Clinical data suggest that progestins have chemopreventive properties in the development of colorectal cancer. We set out to examine a potential protective effect of progestins and progesterone signaling on colon cancer development. In normal and neo

Externí odkaz: https://doaj.org/article/12c30f83960b4a05b201118a2942a0b6

Discovery and Clinical Evaluation of MK‐8150, A Novel Nitric Oxide Donor With a Unique Mechanism of Nitric Oxide Release

Autor: David E. Gutstein, Christopher J. Morabito, Anna Mitselos, Kaushik Mitra, Wen Liu, Peggy H. Wong, Doris F. Cully, Karim Azer, Shu Yu Sun, Clayton D. Knox, Antwan G. Ederveen, Pieter‐Jan de Kam, Michael Man-Chu Lo, Tom Reynders, Alan G. Meehan, Daniel Jonathan, Amjad Ali, Jean Francois Denef, Diane Shevell

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 9, Pp n/a-n/a (2016)

Background Nitric oxide donors are widely used to treat cardiovascular disease, but their major limitation is the development of tolerance, a multifactorial process to which the in vivo release of nitric oxide is thought to contribute. Here we descri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402e3bef922e3d1888227722e6fba249
http://europepmc.org/articles/PMC5079016

Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones

Autor: Kathy J. Krentz, William F. Dove, Alexandra Shedlovsky, Antwan G. Ederveen, Jarom Heijmans, Linda Clipson, Elisa Dunkin, Mattheus C. B. Wielenga, Vanesa Muncan, Daniel W. Hommes, Gijs R. van den Brink, Sietse Mosselman, James M. Amos-Landgraf, Patrick G. Groothuis

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 111(46), 16514-16519. National Academy of Sciences

It recently has been recognized that men develop colonic adenomas and carcinomas at an earlier age and at a higher rate than women. In the Apc(Pirc/+) (Pirc) rat model of early colonic cancer, this sex susceptibility was recapitulated, with male Pirc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78daaaec28385968c49a2ed0caa94c9f
https://pure.amc.nl/en/publications/sex-disparity-in-colonic-adenomagenesis-involves-promotion-by-male-hormones-not-protection-by-female-hormones(29cef3db-5ba5-40aa-abff-e6a022f65574).html

Intestinal Tumorigenesis Is Not Affected by Progesterone Signaling in Rodent Models

Autor: Patrick G. Groothuis, Daniel W. Hommes, Rutger J. Jacobs, Gijs R. van den Brink, Sietse Mosselman, Jarom Heijmans, James C. H. Hardwick, Izak Biemond, Vanesa Muncan, Laura Graven, Antwan G. Ederveen, Eveline S.M. de Jonge-Muller

Publikováno v: PLoS ONE
PloS one, vol 6, iss 7
PLoS ONE, 6(7). Public Library of Science
PLoS ONE, Vol 6, Iss 7, p e22620 (2011)
PLoS ONE, 6(7):e22620. Public Library of Science
PLoS ONE, 6(7)

Clinical data suggest that progestins have chemopreventive properties in the development of colorectal cancer. We set out to examine a potential protective effect of progestins and progesterone signaling on colon cancer development. In normal and neo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3409271a146bef26a0f2af96a57c2726
https://doi.org/10.1371/journal.pone.0022620