Výsledky vyhledávání - "Antwan G Ederveen"

Akademický článek

Intestinal tumorigenesis is not affected by progesterone signaling in rodent models.

Autor: Jarom Heijmans, Vanesa Muncan, Rutger J Jacobs, Eveline S M de Jonge-Muller, Laura Graven, Izak Biemond, Antwan G Ederveen, Patrick G Groothuis, Sietse Mosselman, James C Hardwick, Daniel W Hommes, Gijs R van den Brink

Publikováno v: PLoS ONE, Vol 6, Iss 7, p e22620 (2011)

Clinical data suggest that progestins have chemopreventive properties in the development of colorectal cancer. We set out to examine a potential protective effect of progestins and progesterone signaling on colon cancer development. In normal and neo

Externí odkaz: https://doaj.org/article/12c30f83960b4a05b201118a2942a0b6

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Early Clinical Development Planning via Biomarkers, Clinical Endpoints, and Simulation: A Case Study to Optimize for Phase 3 Dose Selection

Autor: Ghassan N. Fayad, Bret J. Musser, Yue Shentu, Nitin Patel, Lori A. Mixson, James Bolognese, Antwan G. Ederveen, Jaydeep Bhattacharyya

Publikováno v: Therapeutic innovationregulatory science. 49(3)

This study investigated a framework that leverages the relationship between biomarkers and a target clinical endpoint to optimize an early development plan.Different biomarker designs were assessed for proof of concept (PoC) and dose finding (DF) to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d3263a4dfd916cc00c0a4690d5e310
https://pubmed.ncbi.nlm.nih.gov/30222409

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Discovery and Clinical Evaluation of MK‐8150, A Novel Nitric Oxide Donor With a Unique Mechanism of Nitric Oxide Release

Autor: David E. Gutstein, Christopher J. Morabito, Anna Mitselos, Kaushik Mitra, Wen Liu, Peggy H. Wong, Doris F. Cully, Karim Azer, Shu Yu Sun, Clayton D. Knox, Antwan G. Ederveen, Pieter‐Jan de Kam, Michael Man-Chu Lo, Tom Reynders, Alan G. Meehan, Daniel Jonathan, Amjad Ali, Jean Francois Denef, Diane Shevell

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 9, Pp n/a-n/a (2016)

Background Nitric oxide donors are widely used to treat cardiovascular disease, but their major limitation is the development of tolerance, a multifactorial process to which the in vivo release of nitric oxide is thought to contribute. Here we descri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402e3bef922e3d1888227722e6fba249
http://europepmc.org/articles/PMC5079016

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Oestrogens promote tumorigenesis in a mouse model for colitis-associated cancer

Autor: Daniel W. Hommes, Patrick G. Groothuis, Mattheus C. B. Wielenga, Eveline S.M. de Jonge-Muller, James C. H. Hardwick, Joris J. T. H. Roelofs, Gijs R. van den Brink, Izak Biemond, Vanesa Muncan, Antwan G. Ederveen, Sanne L. Rosekrans, Jarom Heijmans, Geert D'Haens, Jooske F. van Lidth de Jeude

Publikováno v: Gut, 63(2), 310-316. BMJ Publishing Group
Gut, 63(2), 310-316

Background Hormone replacement therapy increases the risk of developing ulcerative colitis in postmenopausal women. Chronic intestinal inflammation predisposes to colon cancer development, but effects of female hormones on colitis-associated cancer d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f995ab896a7c303c2c7545a662e3383
https://hdl.handle.net/1887/117386

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Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones

Autor: Kathy J. Krentz, William F. Dove, Alexandra Shedlovsky, Antwan G. Ederveen, Jarom Heijmans, Linda Clipson, Elisa Dunkin, Mattheus C. B. Wielenga, Vanesa Muncan, Daniel W. Hommes, Gijs R. van den Brink, Sietse Mosselman, James M. Amos-Landgraf, Patrick G. Groothuis

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 111(46), 16514-16519. National Academy of Sciences

It recently has been recognized that men develop colonic adenomas and carcinomas at an earlier age and at a higher rate than women. In the Apc(Pirc/+) (Pirc) rat model of early colonic cancer, this sex susceptibility was recapitulated, with male Pirc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78daaaec28385968c49a2ed0caa94c9f
https://pure.amc.nl/en/publications/sex-disparity-in-colonic-adenomagenesis-involves-promotion-by-male-hormones-not-protection-by-female-hormones(29cef3db-5ba5-40aa-abff-e6a022f65574).html

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Correction: Intestinal Tumorigenesis Is Not Affected by Progesterone Signaling in Rodent Models

Autor: Patrick G. Groothuis, Antwan G. Ederveen, Rutger J. Jacobs, Laura Graven, Izak Biemond, Sietse Mosselman, Jarom Heijmans, Eveline S.M. de Jonge-Muller, Gijs R. van den Brink, Daniel W. Hommes, James C. H. Hardwick, Vanesa Muncan

Publikováno v: PLoS ONE, Vol 8, Iss 6 (2013)
PLoS ONE, 8(6). Public Library of Science

[This corrects the article DOI: 10.1371/journal.pone.0022620.].

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f18e7b11e20b8282bec1a985a731edb
http://europepmc.org/articles/PMC6061774

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Intestinal Tumorigenesis Is Not Affected by Progesterone Signaling in Rodent Models

Autor: Patrick G. Groothuis, Daniel W. Hommes, Rutger J. Jacobs, Gijs R. van den Brink, Sietse Mosselman, Jarom Heijmans, James C. H. Hardwick, Izak Biemond, Vanesa Muncan, Laura Graven, Antwan G. Ederveen, Eveline S.M. de Jonge-Muller

Publikováno v: PLoS ONE
PloS one, vol 6, iss 7
PLoS ONE, 6(7). Public Library of Science
PLoS ONE, Vol 6, Iss 7, p e22620 (2011)
PLoS ONE, 6(7):e22620. Public Library of Science
PLoS ONE, 6(7)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3409271a146bef26a0f2af96a57c2726
https://doi.org/10.1371/journal.pone.0022620

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