Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Antun Hutinec"'
Autor:
Stacey M. Southall, Joydeep Banerjee, Jason Brown, Kristina Butkovic, Andrew D. Cansfield, Julie E. Cansfield, Miles S. Congreve, Gabriella Cseke, Francesca Deflorian, Martina Petrovic Hunjadi, Antun Hutinec, Trinadh Kumar Inturi, Renata Rupcic, Gordon Saxty, Stephen P. Watson
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1776-1782
The diastereomeric macrocyclic calcitonin generelated peptide (CGRP) antagonists HTL0029881 (3) and HTL0029882 (4), in which the stereochemistry of a spiro center is reversed, surprisingly demonstrate comparable potency. X-ray crystallographic charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6056f84865bf327ec61e26bf41ed7b3
https://doi.org/10.1021/acsmedchemlett.2c00400
https://doi.org/10.1021/acsmedchemlett.2c00400
Autor:
Andrew D. Cansfield, Mark A. Ator, Joydeep Banerjee, Michael Bestwick, Andrea Bortolato, Giles A. Brown, Jason Brown, Kristina Butkovic, Julie E. Cansfield, John A. Christopher, Miles Congreve, Gabriella Cseke, Francesca Deflorian, Benjamin Dugan, Martina Petrovic Hunjadi, Antun Hutinec, Trinadh Kumar Inturi, Goran Landek, Jonathan Mason, Alistair O’Brien, Gregory R. Ott, Renata Rupcic, Gordon Saxty, Stacey M. Southall, Rahela Zadravec, Stephen P. Watson
Publikováno v:
ACS Chemical Neuroscience. 13:751-765
A series of macrocyclic calcitonin gene-related peptide (CGRP) receptor antagonists identified using structure-based design principles, exemplified by HTL0028016 (1) and HTL0028125 (2), is described. Structural characterization by X-ray crystallograp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c446db762c3a729f140cd365a9977f1b
https://doi.org/10.1021/acschemneuro.1c00696
https://doi.org/10.1021/acschemneuro.1c00696
Autor:
Sulejman, Alihodžić, Mirjana, Bukvić, Ivaylo J, Elenkov, Antun, Hutinec, Sanja, Koštrun, Dijana, Pešić, Gordon, Saxty, Linda, Tomašković, Dinko, Žiher
Publikováno v:
Progress in medicinal chemistry. 57(1)
This chapter will discuss the recent literature of macrocycles and drug-like property space moving beyond the rule of five (bRo5). Trends in chemical classes that fall within this definition are discussed and the impact of the latest technologies in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b7c789c7bd3c1ab58fbe8e972b11b488
https://pubmed.ncbi.nlm.nih.gov/29680148
https://pubmed.ncbi.nlm.nih.gov/29680148
Autor:
Dijana Pesic, Ivaylo Jivkov Elenkov, Antun Hutinec, Linda Tomaskovic, Sanja Koštrun, Mirjana Bukvić, Sulejman Alihodžić, Dinko Žiher, Gordon Saxty
This chapter will discuss the recent literature of macrocycles and drug-like property space moving beyond the rule of five (bRo5). Trends in chemical classes that fall within this definition are discussed and the impact of the latest technologies in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0773aeccbb559a31abb85103d691d875
https://doi.org/10.1016/bs.pmch.2018.01.002
https://doi.org/10.1016/bs.pmch.2018.01.002
Publikováno v:
Tetrahedron Letters. 52:1745-1748
The application of microwave heating to a polymer-assisted solution phase synthesis technique has been used to develop a rapid and efficient protocol for the solution phase synthesis of amides from unprotected polyfunctional 15-membered azalides.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e44977089486ce20d677a4cb55790642
https://doi.org/10.1016/j.tetlet.2011.01.154
https://doi.org/10.1016/j.tetlet.2011.01.154
Autor:
Colin Ohrt, Kirsten S. Smith, Antun Hutinec, Wilbur K. Milhous, Renata Rupčić, Zrinka Ivezić Schönfeld, William Y. Ellis, Dinko Žiher
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:1692-1701
A series of 15-membered azalide urea and thiourea derivatives has been synthesized and evaluated for their in vitro antimalarial activity against chloroquine-sensitive (D6), chloroquine/pyremethamine resistant (W2) and multidrug resistant (TM91C235)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a9d45cdce22d620db66289b16733b6
https://doi.org/10.1016/j.bmc.2011.01.030
https://doi.org/10.1016/j.bmc.2011.01.030
Autor:
Stjepan Mutak, Miljenko Dumić, V. Sunjic, Antun Hutinec, Sulejman Alihodžić, Vesna Eraković Haber, Nataša Maršić, Gorjana Lazarevski, Marko Đerek, Hana Čipčić Paljetak
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3244-3249
Fifteen-membered 8a-aza-8a-homoerythromycins derived from either erythromycin or clarithromycin have been acylated to form 4″-O-propenoyl derivative. These functionalized analogues underwent Michael reaction with primary or secondary amines to affo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e143e8a7738cbf990c57b8c1d97c5f2
https://doi.org/10.1016/j.bmcl.2010.04.062
https://doi.org/10.1016/j.bmcl.2010.04.062
Publikováno v:
ARKIVOC, Vol 2003, Iss 14, Pp 87-97 (2003)
Irradiation of 3-X-2-[2-(2-vinylphenyl)ethenyl]furans (6a, X=CH3 ; 6b, X=Br ; 6c, X=vinyl) gave 2-(3-X-2- furyl)-2, 3-dihydro-1, 3-methano-1H-indenes (14a-c) and 1-X-phenanthrenes (15a-c). The formation of benzobicyclo[2.1.1]hexene structures (14a-c)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025fcc858287b64e9144d7b47eec5e1d
https://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/ark.5550190.0004.e09
https://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/ark.5550190.0004.e09
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :2201-2208
Several quinonoidal spirolactones (1-oxaspiro[4, 5]deca-6, 9-diene-2, 8-diones) 12 have been synthesized chemically or electrochemically by oxidation of the corresponding tyrosine phenols 3. The spirolactones are of considerable value in peptide chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a6db7de277ed0b8e01eb21f809e4d5
https://doi.org/10.1039/a801803k
https://doi.org/10.1039/a801803k
Autor:
Andrea Fajdetić, Dubravko Jelić, Mirjana Bukvić Krajačić, Jasna Padovan, Sulejman Alihodžić, Arba L. Ager, Wilbur K. Milhous, Kirsten S. Smith, Milan Mesic, Dinko Žiher, Radan Spaventi, Antun Hutinec, William Y. Ellis, Mihaela Perić, Goran Landek, Zrinka Ivezić-Schönfeld, Renata Rupčić, Colin Ohrt
Publikováno v:
Journal of medicinal chemistry. 55(3)
Novel classes of antimalarial drugs are needed due to emerging drug resistance. Azithromycin, the first macrolide investigated for malaria treatment and prophylaxis, failed as a single agent and thus novel analogues were envisaged as the next generat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e89530ff62b7a8631590f61d1dc18d3
https://pubmed.ncbi.nlm.nih.gov/22148880
https://pubmed.ncbi.nlm.nih.gov/22148880