Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Antti, Pohjakallio"'
Autor:
Johanna K. Ahlskog, Antti Pohjakallio, Ralf Paul, Martin Augustin, Elisabeth Schneider, Sakshi Johri, Tuomas Tervahauta, Hans-Georg Beisel, Lars Neumann, Julia Lindqvist, Anu Moilanen
Publikováno v:
Cancer Research. 83:6179-6179
Background: DNA Polymerase θ (Polθ) is active in Theta-mediated end joining (TMEJ), a repair pathway that utilizes resected 3’ ends and micro-homology sequences to repair double strand breaks. Polθ contains an N-terminal helicase domain and a C-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a398847ea3513ad142d5cc706bdaf5e
https://doi.org/10.1158/1538-7445.am2023-6179
https://doi.org/10.1158/1538-7445.am2023-6179
Autor:
Shouming, Wang, Anssi, Haikarainen, Antti, Pohjakallio, Julius, Sipilä, Janne, Kaskinoro, Satu, Juhila, Niina, Jalava, Mikko, Koskinen, Marja, Vesajoki, Esa, Kumpulainen, Jarmo, Pystynen, Tuula, Koskelainen, Patrik, Holm, David, Din Belle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 77:129005
Here is reported the design and synthesis of a series of highly potent and selective α2C antagonists using benzodioxine methyl piperazine as a central scaffold by pharmacophoric analysis to improve the pharmacokinetics of suboptimal clinical candida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a79817adb5e1c73186ea6f167f3ba422
https://doi.org/10.1016/j.bmcl.2022.129005
https://doi.org/10.1016/j.bmcl.2022.129005
Autor:
Shouming, Wang, Anssi, Haikarainen, Antti, Pohjakallio, Julius, Sipilä, Janne, Kaskinoro, Satu, Juhila, Niina, Jalava, Mikko, Koskinen, Marja, Vesajoki, Esa, Kumpulainen, Jarmo, Pystynen, Tuula, Koskelainen, Patrik, Holm, David, Din Belle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 69:128783
In this manuscript, we report a series of benzodioxine methyl piperidine derivatives as highly potent and selective α2C antagonists by ligand design to improve the pharmacokinetics of a previous candidate molecule.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11c0582b9e57eabdf758db92785f82e
https://doi.org/10.1016/j.bmcl.2022.128783
https://doi.org/10.1016/j.bmcl.2022.128783
Publikováno v:
Advanced Synthesis & Catalysis. 356:1555-1561
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8afcd567d91583ed855d64ccc18f32d
https://doi.org/10.1002/adsc.201301139
https://doi.org/10.1002/adsc.201301139
Autor:
Petri M. Pihko, Antti Pohjakallio
Publikováno v:
Chemistry - A European Journal. 15:3960-3964
Enantioselective isoxazoline synthesis: A combination of 1) a catalytic enantioselective conjugate addition of oximes to alpha,beta-unsaturated aldehydes and 2) an acid-catalyzed intramolecular oxime-transfer reaction lead to the first asymmetric syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a44686d144136cf9a0929f1731f941
https://doi.org/10.1002/chem.200802684
https://doi.org/10.1002/chem.200802684
Autor:
Petri M. Pihko, Antti Pohjakallio
Publikováno v:
Synlett. 2008:827-830
A new catalytic method for the preparation of 3-unsubstituted 2-isoxazolines is reported. The isoxazolines are easily prepared from the aliphatic α,β-unsaturated aldehydes and simple oximes in the presence of an anilinium salt catalyst.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be05783b8beca808b42ce4b1456affe0
https://doi.org/10.1055/s-2008-1042900
https://doi.org/10.1055/s-2008-1042900
Autor:
Petri M. Pihko, Antti Pohjakallio
Publikováno v:
Synlett. :2115-2118
Catalytic enantioselective α-amination reactions of p-keto esters and p-keto lactones with dibenzyl azodicarboxylate are catalyzed by cinchona alkaloids, affording the products in up to 99% yield and 90% ee.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3868d7fe1ad97f34acc53d0cc0c0d85b
https://doi.org/10.1055/s-2004-831326
https://doi.org/10.1055/s-2004-831326
Publikováno v:
ChemInform. 45
Optimized conditions render possible the highly selective C-5 arylation of pyrazole (I) with a wide variety of aryl bromides.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1696669a105a1173b797ea6cfd5bbef
https://doi.org/10.1002/chin.201442139
https://doi.org/10.1002/chin.201442139
Publikováno v:
ChemInform. 42
Treatment of chiral isoxazoles with catalytic amounts of DBU results in efficient formation of optically active β-hydroxynitriles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b5c22e0910ade5ecdceb0ce609adf9a
https://doi.org/10.1002/chin.201107076
https://doi.org/10.1002/chin.201107076
Publikováno v:
ChemInform. 42
Acidic anilinium salts catalyze the direct formation of racemic 2-isoxazolines from enals and oximes by means of consecutive oxime conjugate-addition and intramolecular oxime-transfer reaction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::467934d0d770ee26c128618974502727
https://doi.org/10.1002/chin.201107160
https://doi.org/10.1002/chin.201107160