Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Antti, Haapalinna"'
Autor:
Eveliina Pollari, Saara Tegelberg, Harry Björklund, Reetta Kälviäinen, Anna-Elina Lehesjoki, Antti Haapalinna
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 17 (2023)
Progressive myoclonus epilepsy type 1 (EPM1) is an autosomal recessively inherited childhood–adolescence onset neurodegenerative disease caused by mutations in the cystatin B (CSTB gene). The key clinical manifestation in EPM1 is progressive, stimu
Externí odkaz:
https://doaj.org/article/1a6df0e2dd9f4a6a809d599f6b3d80be
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 4, Pp n/a-n/a (2021)
Abstract α2‐Adrenoceptor agonists such as clonidine and dexmedetomidine are used as adjuvants to local anesthetics in regional anesthesia. Fadolmidine is an α2‐adrenoceptor agonist developed especially as a spinal analgesic. The current studies
Externí odkaz:
https://doaj.org/article/03043c47ea0f4626a0455857cd6103e5
Autor:
Jyrki, Lehtimäki, Niina, Jalava, Kaisa, Unkila, John, Aspegren, Antti, Haapalinna, Ullamari, Pesonen
Publikováno v:
European journal of pharmacology. 923
The pharmacological profile of tasipimidine, a novel orally active α
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 393:1459-1473
An α2-adrenoceptor agonist, clonidine, is extensively used in both anesthesia and intensive care medicine. However, clonidine may produce pronounced hemodynamic side effects such as hypotension and bradycardia which may limit its usefulness in certa
Publikováno v:
European journal of pharmacology. 882
Fadolmidine is an α2-adrenoceptor full agonist developed for spinal analgesia with a local mode of action. The purpose of this study was to demonstrate the safety of fadolmidine on known α2-adrenoceptor-related effects: kidney function, urodynamics
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 393(8)
An α
Autor:
Jelena Mijatovic, Petteri Piepponen, Katja Kuokkanen, Heikki Tanila, Johanna Holappa, Jukka Sallinen, Raimo Virtanen, Jouni Sirviö, Hugh Chapman, Antti Haapalinna, Ari Koivisto, Jyrki Lehtimäki
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 113:239-249
The α2-adrenoceptors (ARs) are important modulators of a wide array of physiological responses. As only a few selective compounds for the three α2-AR subtypes (α2A , α2B and α2C ) have been available, the pharmacological profile of a new α2C-se
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 380:539-550
The present experiments compared the peripheral and central pharmacological effects of three alpha(2)-adrenoceptor agonists: fadolmidine, clonidine, and dexmedetomidine after single intrathecal bolus injections at analgesic dose level in rats. Effect
Autor:
Ari Koivisto, Raimo Virtanen, Tiina Leino, Tarja Lehtimäki, Katja Kuokkanen, Antti Haapalinna, Jyrki Lehtimäki, Timo Viitamaa
Publikováno v:
European Journal of Pharmacology. 599:65-71
Alpha2-adrenergic receptors (alpha2-adrenoceptors) mediate various physiological actions of endogenous catecholamines in the central and peripheral nervous systems being involved in alertness, heart rate regulation, vasomotor control and nociceptive
Publikováno v:
Pharmacology & Toxicology. 87:242-245