Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Antreas C, Kalli"'
Autor:
Emma Brown, Gemma Swinscoe, Daniella A Lefteri, Ravi Singh, Amy Moran, Rebecca F Thompson, Daniel Maskell, Hannah Beaumont, Matthew J Bentham, Claire Donald, Alain Kohl, Andrew Macdonald, Neil Ranson, Richard Foster, Clive S McKimmie, Antreas C Kalli, Stephen Griffin
Publikováno v:
eLife, Vol 13 (2024)
Flaviviruses, including Zika virus (ZIKV), are a significant global health concern, yet no licensed antivirals exist to treat disease. The small membrane (M) protein plays well-defined roles during viral egress and remains within virion membranes fol
Externí odkaz:
https://doaj.org/article/2ea2a660429141029618f43cf5ee6d6c
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The membrane-bound lymphocyte-specific protein-tyrosine kinase (Lck) triggers T cell antigen receptor signalling to initiate adaptive immune responses. Despite many structure–function studies, the mode of action of Lck and the potential ro
Externí odkaz:
https://doaj.org/article/d48e41c0e0ad4909887a6f3fb90ef561
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 10, p e1010578 (2022)
Membrane-integral pyrophosphatases (mPPases) are membrane-bound enzymes responsible for hydrolysing inorganic pyrophosphate and translocating a cation across the membrane. Their function is essential for the infectivity of clinically relevant protozo
Externí odkaz:
https://doaj.org/article/2b179b09f8644df08a9ca16c37a4c260
Autor:
Matthew G. Iadanza, Bob Schiffrin, Paul White, Matthew A. Watson, Jim E. Horne, Anna J. Higgins, Antonio N. Calabrese, David J. Brockwell, Roman Tuma, Antreas C. Kalli, Sheena E. Radford, Neil A. Ranson
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
With cryo-EM, single-molecule FRET and MD simulations, Iadanza et al. characterise the membrane protein insertase complex BAM in lipid bilayer nanodiscs. They show that the β-barrel domain of BamA is in a ‘lateral open’ conformation, and that BA
Externí odkaz:
https://doaj.org/article/cc183779d41f4d5aabd191eaa4c934aa
Autor:
Antonio N. Calabrese, Bob Schiffrin, Matthew Watson, Theodoros K. Karamanos, Martin Walko, Julia R. Humes, Jim E. Horne, Paul White, Andrew J. Wilson, Antreas C. Kalli, Roman Tuma, Alison E. Ashcroft, David J. Brockwell, Sheena E. Radford
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The chaperone SurA is involved in outer membrane protein (OMP) biogenesis in Gram-negative bacteria, but its mechanism of action is not fully understood. Combining mass spectrometric, biophysical and computational approaches, the authors here show ho
Externí odkaz:
https://doaj.org/article/2047c9564bc341c98f0fa558c55a100a
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Molecular dynamics (MD) simulations have provided new insights into the organization and dynamics of the red blood cell Band 3 anion exchanger (AE1, SLC4A1). Band 3, like many solute carriers, works by an alternating access mode of transport where th
Externí odkaz:
https://doaj.org/article/25650ba89f2d480589caef9ae4380765
Autor:
Anna-Lisa Lanz, Giulia Masi, Nicla Porciello, André Cohnen, Deborah Cipria, Dheeraj Prakaash, Štefan Bálint, Roberto Raggiaschi, Donatella Galgano, David K. Cole, Marco Lepore, Omer Dushek, Michael L. Dustin, Mark S.P. Sansom, Antreas C. Kalli, Oreste Acuto
Publikováno v:
Cell Reports, Vol 36, Iss 6, Pp 109531- (2021)
Externí odkaz:
https://doaj.org/article/a6cb432e0b0a4011bea51b73db0ce5dd
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 7, p e1009232 (2021)
The T cell receptor (TCR-CD3) initiates T cell activation by binding to peptides of Major Histocompatibility Complexes (pMHC). The TCR-CD3 topology is well understood but the arrangement and dynamics of its cytoplasmic tails remains unknown, limiting
Externí odkaz:
https://doaj.org/article/eef43c7c0731423c8ca702ee06b2de21
Autor:
Jian Shi, Adam J. Hyman, Dario De Vecchis, Jiehan Chong, Laeticia Lichtenstein, T. Simon Futers, Myriam Rouahi, Anne Negre Salvayre, Nathalie Auge, Antreas C. Kalli, David J. Beech
Publikováno v:
Cell Reports, Vol 33, Iss 1, Pp 108225- (2020)
Summary: Endogenous PIEZO1 channels of native endothelium lack the hallmark inactivation often seen when these channels are overexpressed in cell lines. Because prior work showed that the force of shear stress activates sphingomyelinase in endotheliu
Externí odkaz:
https://doaj.org/article/f6b344136b464cb480bd078a6a9a4088
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2019)
Membrane integral pyrophosphatases (mPPases) are responsible for the hydrolysis of pyrophosphate. This enzymatic mechanism is coupled to the pumping of H+ or Na+ across membranes in a process that can be K+ dependent or independent. Understanding the
Externí odkaz:
https://doaj.org/article/2d41e110bfbf4546b2bb29b9f33da4a2