Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Antra Zeltina"'
Autor:
Natalie J. Kingston, Keith Grehan, Joseph S. Snowden, Mark Hassall, Jehad Alzahrani, Guido C. Paesen, Lee Sherry, Connor Hayward, Amy Roe, Sam Stephen, Darren Tomlinson, Antra Zeltina, Katie J. Doores, Neil A. Ranson, Martin Stacey, Mark Page, Nicola J. Rose, Thomas A. Bowden, David J. Rowlands, Nicola J. Stonehouse
Publikováno v:
mSphere, Vol 8, Iss 1 (2023)
ABSTRACT Having varied approaches to the design and manufacture of vaccines is critical in being able to respond to worldwide needs and newly emerging pathogens. Virus-like particles (VLPs) form the basis of two of the most successful licensed vaccin
Externí odkaz:
https://doaj.org/article/b7c301ef9e3a4446bd7a97505024123b
Autor:
Weng M. Ng, Mehmet Sahin, Stefanie A. Krumm, Jeffrey Seow, Antra Zeltina, Karl Harlos, Guido C. Paesen, Daniel D. Pinschewer, Katie J. Doores, Thomas A. Bowden
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Transmission of the New World hemorrhagic fever arenaviruses Junín virus (JUNV) and Machupo virus (MACV) to humans is facilitated, in part, by the interaction between the arenavirus GP1 glycoprotein and the human transferrin receptor 1 (hTf
Externí odkaz:
https://doaj.org/article/c0526be8772c4f10948cbdf141eb261d
Autor:
Jonathan Powlson, Daniel Wright, Antra Zeltina, Mark Giza, Morten Nielsen, Tommy Rampling, Navin Venkatrakaman, Thomas A. Bowden, Adrian V.S. Hill, Katie J. Ewer
Publikováno v:
Cell Reports, Vol 29, Iss 9, Pp 2537-2545.e3 (2019)
Summary: Ebolavirus causes highly lethal hemorrhagic fever in humans. The envelope-displayed viral glycoprotein (GP) is the primary target of humoral immunity induced by natural exposure and vaccination. No T cell epitopes in the GP have been charact
Externí odkaz:
https://doaj.org/article/ebe16cc1a325464592d23c4905d28974
Autor:
Sai Li, Ilona Rissanen, Antra Zeltina, Jussi Hepojoki, Jayna Raghwani, Karl Harlos, Oliver G. Pybus, Juha T. Huiskonen, Thomas A. Bowden
Publikováno v:
Cell Reports, Vol 15, Iss 5, Pp 959-967 (2016)
Hantaviruses, a geographically diverse group of zoonotic pathogens, initiate cell infection through the concerted action of Gn and Gc viral surface glycoproteins. Here, we describe the high-resolution crystal structure of the antigenic ectodomain of
Externí odkaz:
https://doaj.org/article/2d7f19f22de2439fada439d2843905af
Publikováno v:
PLoS Pathogens, Vol 12, Iss 2, p e1005390 (2016)
Externí odkaz:
https://doaj.org/article/9eeabe1e29e14209ae658fce6448dbee
Autor:
Natalie J Kingston, Keith Grehan, Joseph S Snowden, Mark Hassall, Jehad Alzahrani, Guido C Paesen, Lee Sherry, Connor Hayward, Amy Roe, Sam Stephen, Darren Tomlinson, Antra Zeltina, Katie J Doores, Neil A Ranson, Martin Stacey, Mark Page, Nicola J Rose, Thomas A Bowden, David J Rowlands, Nicola J Stonehouse
Having varied approaches to the design and manufacture of vaccines is critical in being able to respond to worldwide needs and to newly emerging pathogens. Virus-like particle (VLP) vaccines form the basis of two of the most successful licensed vacci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0345f2318ac7709ebb7dabbc45162e8e
https://doi.org/10.1101/2022.04.22.489148
https://doi.org/10.1101/2022.04.22.489148
Autor:
Tommy Rampling, Antra Zeltina, Morten Nielsen, Mark Giza, Jonathan Powlson, Thomas A. Bowden, Adrian V. S. Hill, Daniel B. Wright, Katie J. Ewer, Navin Venkatrakaman
Publikováno v:
Cell Reports
Cell Reports, Vol 29, Iss 9, Pp 2537-2545.e3 (2019)
Powlson, J, Wright, D, Zeltina, A, Giza, M, Nielsen, M, Rampling, T, Venkatrakaman, N, Bowden, T A, Hill, A V S & Ewer, K J 2019, ' Characterization of Antigenic MHC-Class-I-Restricted T Cell Epitopes in the Glycoprotein of Ebolavirus ', Cell Reports, vol. 29, no. 9, pp. 2537-2545.e3 . https://doi.org/10.1016/j.celrep.2019.10.105
Cell Reports, Vol 29, Iss 9, Pp 2537-2545.e3 (2019)
Powlson, J, Wright, D, Zeltina, A, Giza, M, Nielsen, M, Rampling, T, Venkatrakaman, N, Bowden, T A, Hill, A V S & Ewer, K J 2019, ' Characterization of Antigenic MHC-Class-I-Restricted T Cell Epitopes in the Glycoprotein of Ebolavirus ', Cell Reports, vol. 29, no. 9, pp. 2537-2545.e3 . https://doi.org/10.1016/j.celrep.2019.10.105
Summary Ebolavirus causes highly lethal hemorrhagic fever in humans. The envelope-displayed viral glycoprotein (GP) is the primary target of humoral immunity induced by natural exposure and vaccination. No T cell epitopes in the GP have been characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453d595c85aa7dfae6aae446d1b262ee
https://doi.org/10.1016/j.celrep.2019.10.105
https://doi.org/10.1016/j.celrep.2019.10.105
Autor:
Antra Zeltina, Elizabeth E. Fry, Daniel M. Jones, Yuguang Zhao, Thomas A. Bowden, Sergi Padilla-Parra, Jingshan Ren, Karl Harlos, David I. Stuart
Publikováno v:
Nature
High-resolution structures of the unliganded Ebola virus glycoprotein (GP) and of GP bound to the drugs toremifene and ibuprofen are presented, providing insights into how the drugs inhibit viral fusion with the endosomal membrane. David Stuart and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::448d57fa7262921786812c1759c2a7b5
http://europepmc.org/articles/PMC4947387
http://europepmc.org/articles/PMC4947387
Autor:
Stuart D. Dowall, Ibrahim Al-Abdulla, Irene Taylor, Andrew Bosworth, Jo Callan, Sue Charlton, Antra Zeltina, Ian D. Cameron, John Landon, Verena Krähling, Roger Hewson, Abdulsalami Nasidi, Emma Rayner, Thomas Strecker, Thomas A. Bowden, Miles W. Carroll, Sarah Katharina Fehling
Publikováno v:
The Journal of Infectious Diseases
The highly glycosylated glycoprotein spike of Ebola virus (EBOV-GP1,2) is the primary target of the humoral host response. Recombinant EBOV-GP ectodomain (EBOV-GP1,2ecto) expressed in mammalian cells was used to immunize sheep and elicited a robust i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97ed2d98d69255c8bf930ae7e522d2e
https://doi.org/10.1093/infdis/jiv565
https://doi.org/10.1093/infdis/jiv565
Publikováno v:
Nat. Struct. Mol. Biol.
HmuUV is a bacterial ATP-binding cassette (ABC) transporter that catalyzes heme uptake into the cytoplasm of the gram-negative pathogen Yersinia pestis. We report the crystal structure of HmuUV at 3.0 Å resolution in a nucleotide-free state, which f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7904b2d92b497abbb9c6fd694791bf7c
https://doi.org/10.1038/nsmb.2417
https://doi.org/10.1038/nsmb.2417