Allergen-specific subcutaneous immunotherapy in allergic asthma: immunologic mechanisms and improvement

Autor: Yousef A. Taher, Paul A.J. Henricks, Antoon J.M. van Oosterhout

Publikováno v: Libyan Journal of Medicine, Vol 5, Iss 0, Pp 1-11 (2010)

Allergic asthma is a disease characterized by persistent allergen-driven airway inflammation, remodeling, and airway hyperresponsiveness. CD4+ T-cells, especially T-helper type 2 cells, play a critical role in orchestrating the disease process throug

Externí odkaz: https://doaj.org/article/b14d4823890e4c68865255f7a6f6c4a5

Allergen immunotherapy for allergic airway diseases

Autor: Laura Hesse, J.N.G. Oude Elberink, Antoon J.M. van Oosterhout, Martijn C. Nawijn

Publikováno v: Pharmacology & Therapeutics. 237

Allergic respiratory diseases, such as allergic dermatitis, food allergy, allergic rhino conjunctivitis and allergic asthma, are chronic inflammatory diseases with increasing prevalence. Symptoms include such as watery or itchy itching of the mouth,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d673c6662c954eff7e7866e9e2ed3e70
https://doi.org/10.1016/j.pharmthera.2022.108115

Allergen immunotherapy induces a suppressive memory response mediated by IL-10 in a mouse asthma model

Autor: Joost Lambert Max Vissers, Frank Reinoud Weller, Antoon J.M. Van Oosterhout, Martien L. Kapsenberg, Betty C.A.M. van Esch, Gerard A. Hofman

Publikováno v: Journal of Allergy and Clinical Immunology, 113(6), 1204-1210. MOSBY-ELSEVIER
Journal of allergy and clinical immunology, 113(6), 1204-1210. Mosby Inc.

Background Human studies have demonstrated that allergen immunotherapy induces memory suppressive responses and IL-10 production by allergen-specific T cells. Previously, we established a mouse model in which allergen immunotherapy was effective in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82ac2901a57a6f67c107d79dac838e3
https://research.rug.nl/en/publications/090abdd3-9f0a-4fbb-bd17-bbbe23dda193

The Efficacy of Immunotherapy in an Experimental Murine Model of Allergic Asthma Is Related to the Strength and Site of T Cell Activation During Immunotherapy

Autor: Edith M. Janssen, Antoon J.M. Van Oosterhout, Willem van Eden, Frans P. Nijkamp, Marca H. M. Wauben

Publikováno v: The Journal of Immunology. 165:7207-7214

In the present study, the relation between the efficacy of immunotherapy, and the strength and site of T cell activation during immunotherapy was evaluated. We used a model of allergic asthma in which OVA-sensitized and OVA-challenged mice display in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755fafc4ee339a35045f4b5da89343fb
https://doi.org/10.4049/jimmunol.165.12.7207

Recombinant interleukin-5 induces in vivo airway hyperresponsiveness to histamine in guinea pigs

Autor: Gerard A. Hofman, Huub F. J. Savelkoul, Frans P. Nijkamp, Ingrid van Ark, Antoon J.M. Van Oosterhout

Publikováno v: European Journal of Pharmacology, 236(3), 379-383
European Journal of Pharmacology 236 (1993) 3

Interleukin-5-producing CV-1 cells were encapsulated in alginate and injected i.p. in guinea pigs (4 × 10 6 /animal). These cells produced approximately 8 ng interleukin-5 per 4 × 10 6 cells per day. Airway hyperresponsiveness to histamine in vivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c4e8c175d5521d4420f4481156d49a
https://doi.org/10.1016/0014-2999(93)90475-w