Výsledky vyhledávání - "Antony W. Braithwaite"

Akademický článek

Activated CD90/Thy-1 fibroblasts co-express the Δ133p53β isoform and are associated with highly inflamed rheumatoid arthritis

Autor: Anna K. Wiles, Sunali Mehta, Melanie Millier, Adele G. Woolley, Kunyu Li, Kim Parker, Marina Kazantseva, Michelle Wilson, Katie Young, Sarah Bowie, Sankalita Ray, Tania L. Slatter, Lisa K. Stamp, Paul A. Hessian, Antony W. Braithwaite

Publikováno v: Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-16 (2023)

Abstract Background The p53 isoform Δ133p53β is known to be associated with cancers driven by inflammation. Many of the features associated with the development of inflammation in rheumatoid arthritis (RA) parallel those evident in cancer progressi

Externí odkaz: https://doaj.org/article/e9733e4ad8ae4413aeea4bee5006da64

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Akademický článek

Alterations in the p53 isoform ratio govern breast cancer cell fate in response to DNA damage

Autor: Luiza Steffens Reinhardt, Xiajie Zhang, Kira Groen, Brianna C. Morten, Geoffry N. De Iuliis, Antony W. Braithwaite, Jean-Christophe Bourdon, Kelly A. Avery-Kiejda

Publikováno v: Cell Death and Disease, Vol 13, Iss 10, Pp 1-18 (2022)

Abstract Our previous studies have shown that p53 isoform expression is altered in breast cancer and related to prognosis. In particular, a high ∆40p53:p53α ratio is associated with worse disease-free survival. In this manuscript, the influence of

Externí odkaz: https://doaj.org/article/9cb81a5c712a40c4a75be9cdbbd0bfac

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Akademický článek

Effect of p53 and its N‐terminally truncated isoform, Δ40p53, on breast cancer migration and invasion

Autor: Xiajie Zhang, Kira Groen, Brianna C. Morten, Luiza Steffens Reinhardt, Hamish G. Campbell, Antony W. Braithwaite, Jean‐Christophe Bourdon, Kelly A. Avery‐Kiejda

Publikováno v: Molecular Oncology, Vol 16, Iss 2, Pp 447-465 (2022)

Breast cancer is the most diagnosed malignancy in women, with over half a million women dying from this disease each year. In our previous studies, ∆40p53, an N‐terminally truncated p53 isoform, was found to be upregulated in breast cancers, and

Externí odkaz: https://doaj.org/article/d096e9855e9f4682af97e433816271a0

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Akademický článek

∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Aberrant expression of the Δ133p53 isoform is linked to many cancers. Here, the authors utilise a model of the Δ133p53 isoform that is prone to tumours and inflammation, showing that Δ133p53 promotes tumour cell invasion by activation of the JAK-S

Externí odkaz: https://doaj.org/article/4c1f6ec1d79b419c8e9e3bfbf63ac5e5

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Akademický článek

Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression

Autor: Marina Kazantseva, Noelyn A. Hung, Sunali Mehta, Imogen Roth, Ramona Eiholzer, Alison M. Rich, Benedict Seo, Margaret A. Baird, Antony W. Braithwaite, Tania L. Slatter

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)

Abstract Accumulating evidence suggests tumor protein 53 (p53) promotes correct cellular differentiation. Thus, mutant TP53 may be more frequent in tumors with irregular differentiation. This study investigated whether TP53 mutations were more freque

Externí odkaz: https://doaj.org/article/969e6784a7154eea9c67d1c473e2032f

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Akademický článek

Enhanced isolation of fibroblasts from human skin explants

Autor: Lily I. Huschtscha, Christine E. Napier, Jane R. Noble, Kylie Bower, Amy Y.M. Au, Hamish G. Campbell, Antony W. Braithwaite, Roger R. Reddel

Publikováno v: BioTechniques, Vol 53, Iss 4, Pp 239-244 (2012)

Here we describe a method for growing fibroblasts from human skin explants that increases the number of cells obtained by up to two orders of magnitude, thus increasing the amount of material available for research and diagnostic purposes and potenti

Externí odkaz: https://doaj.org/article/bc987da89fe24c3089e5110360f03c75

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