Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Antony W Oliver"'
Autor:
Alice M Budden, Murat Eravci, Adam T Watson, Eduard Campillo-Funollet, Antony W Oliver, Karel Naiman, Antony M Carr
Publikováno v:
eLife, Vol 12 (2023)
Arrested replication forks, when restarted by homologous recombination, result in error-prone DNA syntheses and non-allelic homologous recombination. Fission yeast RTS1 is a model fork barrier used to probe mechanisms of recombination-dependent resta
Externí odkaz:
https://doaj.org/article/823a7db80f5f4850904e186ae21c686d
Autor:
Thomas J Etheridge, Desiree Villahermosa, Eduard Campillo-Funollet, Alex David Herbert, Anja Irmisch, Adam T Watson, Hung Q Dang, Mark A Osborne, Antony W Oliver, Antony M Carr, Johanne M Murray
Publikováno v:
eLife, Vol 10 (2021)
The essential Smc5/6 complex is required in response to replication stress and is best known for ensuring the fidelity of homologous recombination. Using single-molecule tracking in live fission yeast to investigate Smc5/6 chromatin association, we s
Externí odkaz:
https://doaj.org/article/a87f3e7fa1b34575930f08ff8d91c899
Autor:
Xiangrong Chen, Yusuf I Ali, Charlotte EL Fisher, Raquel Arribas-Bosacoma, Mohan B Rajasekaran, Gareth Williams, Sarah Walker, Jessica R Booth, Jessica JR Hudson, S Mark Roe, Laurence H Pearl, Simon E Ward, Frances MG Pearl, Antony W Oliver
Publikováno v:
eLife, Vol 10 (2021)
BLM (Bloom syndrome protein) is a RECQ-family helicase involved in the dissolution of complex DNA structures and repair intermediates. Synthetic lethality analysis implicates BLM as a promising target in a range of cancers with defects in the DNA dam
Externí odkaz:
https://doaj.org/article/9ec1a9ebd4b44f678f41f09602610beb
Autor:
Nicolas Bigot, Matthew Day, Robert A Baldock, Felicity Z Watts, Antony W Oliver, Laurence H Pearl
Publikováno v:
eLife, Vol 8 (2019)
Coordination of the cellular response to DNA damage is organised by multi-domain ‘scaffold’ proteins, including 53BP1 and TOPBP1, which recognise post-translational modifications such as phosphorylation, methylation and ubiquitylation on other pr
Externí odkaz:
https://doaj.org/article/91d10f077db94493b4f770071de85788
Autor:
Matthew Day, Mathieu Rappas, Katie Ptasinska, Dominik Boos, Antony W Oliver, Laurence H Pearl
Publikováno v:
eLife, Vol 7 (2018)
TOPBP1 and its fission yeast homologue Rad4, are critical players in a range of DNA replication, repair and damage signalling processes. They are composed of multiple BRCT domains, some of which bind phosphorylated motifs in other proteins. They thus
Externí odkaz:
https://doaj.org/article/63e82e1173f6422187a3405f665b6d76
Autor:
Philip J Byrd, Grant S Stewart, Anna Smith, Charlotte Eaton, Alexander J Taylor, Chloe Guy, Ieva Eringyte, Peggy Fooks, James I Last, Robert Horsley, Antony W Oliver, Dragana Janic, Lidija Dokmanovic, Tatjana Stankovic, A Malcolm R Taylor
Publikováno v:
PLoS Genetics, Vol 12, Iss 3, p e1005945 (2016)
Patients with biallelic truncating mutations in PALB2 have a severe form of Fanconi anaemia (FA-N), with a predisposition for developing embryonal-type tumours in infancy. Here we describe two unusual patients from a single family, carrying biallelic
Externí odkaz:
https://doaj.org/article/4ca4cfd430634bbbb739e182954dea88
Autor:
Matthew Day, Bilal Tetik, Milena Parlak, Yasser Almeida-Hernández, Markus Räschle, Farnusch Kaschani, Heike Siegert, Anika Marko, Elsa Sanchez-Garcia, Markus Kaiser, Isabel A. Barker, Laurence H. Pearl, Antony W. Oliver, Dominik Boos
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Activation of the replicative Mcm2-7 helicase by loading GINS and Cdc45 is crucial for replication origin firing, and as such for faithful genetic inheritance. Our biochemical and structural studies demonstrate that the helicase activator GI
Externí odkaz:
https://doaj.org/article/91e316aec1f548cab215f4d414dc36db
Autor:
Nadia Hégarat, Clare Vesely, P K Vinod, Cory Ocasio, Nisha Peter, Julian Gannon, Antony W Oliver, Béla Novák, Helfrid Hochegger
Publikováno v:
PLoS Genetics, Vol 10, Iss 1, p e1004004 (2014)
Entry into mitosis is triggered by activation of Cdk1 and inactivation of its counteracting phosphatase PP2A/B55. Greatwall kinase inactivates PP2A/B55 via its substrates Ensa and ARPP19. Both Greatwall and Ensa/ARPP19 are regulated by phosphorylatio
Externí odkaz:
https://doaj.org/article/a8ec7b573e9743e3938c8cb598895b1e
Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2.
Autor:
M Cris Silva-Santisteban, Isaac M Westwood, Kathy Boxall, Nathan Brown, Sam Peacock, Craig McAndrew, Elaine Barrie, Meirion Richards, Amin Mirza, Antony W Oliver, Rosemary Burke, Swen Hoelder, Keith Jones, G Wynne Aherne, Julian Blagg, Ian Collins, Michelle D Garrett, Rob L M van Montfort
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65689 (2013)
Checkpoint kinase 2 (CHK2) is an important serine/threonine kinase in the cellular response to DNA damage. A fragment-based screening campaign using a combination of a high-concentration AlphaScreen™ kinase assay and a biophysical thermal shift ass
Externí odkaz:
https://doaj.org/article/d0694d58cc464620a9a172b566b0062e
Autor:
Matthew Day, Bilal Tetik, Milena Parlak, Yasser Almeida-Hernández, Markus Räschle, Farnusch Kaschani, Heike Siegert, Anika Marko, Elsa Sanchez-Garcia, Markus Kaiser, Isabel A. Barker, Laurence H. Pearl, Antony W. Oliver, Dominik Boos
How the replicative Mcm2-7 helicase is activated during replication origin firing remains largely unknown. Our biochemical and structural studies reported here, demonstrate that the helicase activator GINS interacts with TopBP1 through two separate b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7c87ef96a2c3ea57289ac5d3d917811
https://doi.org/10.1101/2023.03.31.535063
https://doi.org/10.1101/2023.03.31.535063