Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Antony Symons"'
Autor:
Antony Symons, Wenjun Ouyang
Publikováno v:
EBioMedicine, Vol 25, Iss C, Pp 20-21 (2017)
Th17 cells, which express the cytokine IL-17A, and master regulator RORγt, are important in the inflammatory response to fungal and bacterial pathogens, but also have a pathogenic role in many inflammatory disorders. In contrast, regulatory T cells
Externí odkaz:
https://doaj.org/article/612aaa23649040f59b56dee13b1cf23e
Autor:
Simon Rousseau, Matoula Papoutsopoulou, Antony Symons, Dorthe Cook, John M. Lucocq, Alan R. Prescott, Anne O'Garra, Steven C. Ley, Philip Cohen
Publikováno v:
Journal of Cell Science. 135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e04e06f4a84711a61e6baca72df206bd
https://doi.org/10.1242/jcs.260708
https://doi.org/10.1242/jcs.260708
Autor:
Stella Aslibekyan, Janie F. Shelton, Teresa Filshtein-Sonmez, Chelsea Ye, Adam Auton, Daniella Coker, Antony Symons, Anjali J. Shastri, Jorge Esparza-Gordillo, Catherine H. Weldon
Publikováno v:
Nature Genetics. 53:801-808
COVID-19 presents with a wide range of severity, from asymptomatic in some individuals to fatal in others. Based on a study of 1,051,032 23andMe research participants, we report genetic and nongenetic associations with testing positive for SARS-CoV-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e64c86bd7caeb1b744e8db49f9cd97
https://doi.org/10.1038/s41588-021-00854-7
https://doi.org/10.1038/s41588-021-00854-7
Autor:
Zhiyu Huang, Antony Symons, Laura Sekirov, Boxi Kang, Dan Wolak, Nathan Pierce, Wenjun Ouyang, Jason DeVoss, Deepali V. Sawant, Xian Liu, Zemin Zhang, Kristy Perez, Liangtao Zheng, Julie Y. Huang, Paolo Manzanillo, Dev Bhatt
Publikováno v:
The Journal of Experimental Medicine
Single cell RNAseq analyses were performed on T cells from MC38 and CT26 tumor models. PCA-based sub-clustering and STARTRAC analyses revealed fine-tuned T cell subsets and dynamic in tumor. CCR8 was identified as a novel target on Tregs to synergize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430731e8ed0ed8f2fda88039ced175c8
https://doi.org/10.1084/jem.20201329
https://doi.org/10.1084/jem.20201329
Autor:
Xiaoshan Min, Ryan White, Sanjay Singh, Anjan Chakrabarti, Jun Hirata, Ryota Nakajima, Tomohide Ida, Hiroyuki Oono, Antony Symons, Keiko Kumazawa, Zhulun Wang, Srinivasa Reddy Mothe, Angel Guzman-Perez, Satoshi Shuto, Sergei Belyakov
Publikováno v:
Bioorganicmedicinal chemistry letters. 36
The retinoic acid receptor-related orphan nuclear receptor gamma t (RORγt), which is a promising therapeutic target for immune diseases, is a major transcription factor of genes related to psoriasis pathogenesis, such as interleukin (IL)-17A, IL-22,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c8d1269a03ac78c50a615b2c5680742
https://pubmed.ncbi.nlm.nih.gov/33493627
https://pubmed.ncbi.nlm.nih.gov/33493627
Autor:
Jorge Esparza-Gordillo, Catherine H. Weldon, Stella Aslibekyan, Teresa Filshtein-Somnez, Janie F. Shelton, Chelsea Ye, Antony Symons, Adam Auton, Anjali J. Shastri, Daniella Coker
COVID-19 presents with a wide range of severity, from asymptomatic in some individuals to fatal in others. Based on a study of over one million 23andMe research participants, we report genetic and non-genetic associations with testing positive for CO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55b50ba112843fcb587051abe6925952
https://doi.org/10.1101/2020.09.04.20188318
https://doi.org/10.1101/2020.09.04.20188318
Autor:
Shinji Kakuda, Akito Makino, Ryan White, Xiaoshan Min, Yohei Matsueda, Jun Hirata, Tomohide Ida, Angel Guzman-Perez, Sakae Sugiyama, Anjan Chakrabarti, Ryan Ρ. Wurz, Zhulun Wang, Sanjay K. Singh, Youngsook Shin, Hiroyuki Oono, Ryota Nakajima, Srinivasa Reddy Mothe, Sergei Belyakov, Atsushi Baba, Ryo Matsuyama, Antony Symons, Satoshi Shuto
Publikováno v:
ACS Med Chem Lett
[Image: see text] The retinoic acid receptor-related orphan nuclear receptor γt (RORγt), a promising therapeutic target, is a major transcription factor of genes related to psoriasis pathogenesis such as interleukin (IL)-17A, IL-22, and IL-23R. On
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce4e53dc562a141ea5cf0e8b2470a7d
https://europepmc.org/articles/PMC7153279/
https://europepmc.org/articles/PMC7153279/
Autor:
John A. Davis, Yu Zhang, James B. Rottman, Fergus R. Byrne, Jeannette Bigler, Alison L. Budelsky, Carole L. Smith, Antony Symons, Mike Fiorino, William A. Brown, Erin Stevens, Joseph R. Maxwell, Jennifer E. Towne
Publikováno v:
Immunity. 43(4):739-750
SummaryInterleukin-23 (IL-23) and IL-17 are cytokines currently being targeted in clinical trials. Although inhibition of both of these cytokines is effective for treating psoriasis, IL-12 and IL-23 p40 inhibition attenuates Crohn’s disease, wherea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c5b9dc146ce130e7b12a123c458cd9f
Autor:
Wenjun Ouyang, Antony Symons
Publikováno v:
EBioMedicine, Vol 25, Iss C, Pp 20-21 (2017)
EBioMedicine
EBioMedicine
The molecular mechanisms that govern differential T cell development into pro-inflammatory Th17 vs. regulatory T (Treg) cells remain unclear. Here, we show that selective deletion of CREB in T cells or Th17 cells impaired Th17 cell differentiation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4cb831ea1cdff8dcf3fbb7666b3470d
http://www.sciencedirect.com/science/article/pii/S2352396417304395
http://www.sciencedirect.com/science/article/pii/S2352396417304395
Autor:
Monica P Belich, Dimitris Kioussis, Stamatia Papoutsopoulou, Frank Kaiser, Anne O'Garra, Antony Symons, Victor L. J. Tybulewicz, Tharsana Tharmalingham, Steven C. Ley
Publikováno v:
Nature Immunology. 7:606-615
The TPL-2 MEK kinase is essential for activation of the Erk MAP kinase pathway during innate immune responses. TPL-2 is found in complex with ABIN-2 (A20-binding inhibitor of NF-kappaB 2). Here, using antigen-presenting cells from ABIN-2-deficient mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ec59e0375f5ef0beafbff76275bd4fb
https://doi.org/10.1038/ni1334
https://doi.org/10.1038/ni1334