Trans-ancestry analysis reveals genetic and nongenetic associations with COVID-19 susceptibility and severity

Autor: Stella Aslibekyan, Janie F. Shelton, Teresa Filshtein-Sonmez, Chelsea Ye, Adam Auton, Daniella Coker, Antony Symons, Anjali J. Shastri, Jorge Esparza-Gordillo, Catherine H. Weldon

Publikováno v: Nature Genetics. 53:801-808

COVID-19 presents with a wide range of severity, from asymptomatic in some individuals to fatal in others. Based on a study of 1,051,032 23andMe research participants, we report genetic and nongenetic associations with testing positive for SARS-CoV-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e64c86bd7caeb1b744e8db49f9cd97
https://doi.org/10.1038/s41588-021-00854-7

Dual Mechanisms for Balancing Th17 and Treg Cell Fate by CREB

Autor: Antony Symons, Wenjun Ouyang

Publikováno v: EBioMedicine, Vol 25, Iss C, Pp 20-21 (2017)

Th17 cells, which express the cytokine IL-17A, and master regulator RORγt, are important in the inflammatory response to fungal and bacterial pathogens, but also have a pathogenic role in many inflammatory disorders. In contrast, regulatory T cells

Externí odkaz: https://doaj.org/article/612aaa23649040f59b56dee13b1cf23e

Genetic mechanisms of critical illness in COVID-19

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Roberta, Russo, Immacolata, Andolfo, Achille, Iolascon, Giuseppe, Fiorentino, Massimo, Carella, Marco, Castori, Giuseppe, Merla, Filippo, Aucella, Pamela, Raggi, Carmen, Marciano, Rita, Perna, Matteo, Bassetti, Antonio Di Biagio, Maurizio, Sanguinetti, Luca, Masucci, Valente, Serafina, Marco, Mandalà, Giorli, Alessia, Salerni, Lorenzo, Patrizia, Zucchi, Pierpaolo, Parravicini, Elisabetta, Menatti, Stefano, Baratti, Tullio, Trotta, Ferdinando, Giannattasio, Gabriella, Coiro, Fabio, Lena, Domenico, A Coviello, Cristina, Mussini, Giancarlo, Bosio, Enrico, Martinelli, Sandro, Mancarella, Luisa, Tavecchia, Lia, Crotti, Nicola, Picchiotti, Marco, Gori, Chiara, Gabbi, Maurizio, Sanarico, Stefano, Ceri, Pietro, Pinoli, Francesco, Raimondi, Filippo, Biscarini, Alessandra, Stella, Alessandra, Shen, Xia, Ponting, Chris P, Fawkes, Angie, Tenesa, Albert, Caulfield, Mark, Scott, Richard, Rowan, Kathy, Murphy, Lee, Openshaw, Peter J M, Semple, Malcolm G, Law, Andrew, Vitart, Veronique, Wilson, James F, Baillie, J Kenneth

Publikováno v: Nature
GenOMICC Investigators 2020, ' Genetic mechanisms of critical illness in Covid-19 ', Nature, pp. 92-98 . https://doi.org/10.1038/s41586-020-03065-y
NATURE
Horner, D 2021, ' Genetic mechanisms of critical illness in COVID-19 ', Nature, vol. 591, 7848, pp. 92-98 . https://doi.org/10.1038/s41586-020-03065-y
Nature (Lond.) 591 (2021): 92–98. doi:10.1038/s41586-020-03065-y
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Latif M.; Bunni L.; Spivey M.; Bean S.; Burt K.; Linnett V.; Ritzema J.; Sanderson A.; McCormick W.; Bokhari M.; Kapoor R.; Loader D.; Ayers A.; Harrison W.; North J.; Belagodu Z.; Paramsothy R.; Olufuwa O.; Gherman A.; Fuller B.; Stuart C.; Kelsall O.; Davis C.; Wild L.; Wood H.; Thrush J.; Durie A.; Austin K.; Archer K.; Anderson P.; Vigurs C.; Thorpe C.; Thomas A.; Knights E.; Boyle N.; Price A.; Kubisz-Pudelko A.; Wood D.; Lewis A.; Board S.; Pippard L.; Perry J.; Beesley K.; Rattray A.; Taylor M.; Lee E.; Lennon L.; Douglas K.; Bell D.; Boyle R.; Glass L.; Nauman Akhtar M.; Dent K.; Potoczna D.; Pearson S.; Horsley E.; Spencer S.; Phillips C.; Mullan D.; Skinner D.; Gaylard J.; Ortiz-Ruiz de Gordoa L.; Barber R.; Hewitt C.; Hilldrith A.; Shepardson S.; Wills M.; Jackson-Lawrence K.; Gupta A.; Easthope A.; Timlick E.; Gorman C.; Otahal I.; Gales A.; Coetzee S.; Sell C.; Raj M.; Peiu M.; Parris V.; Quaid S.; Watson E.; Elliott K.; Mallinson J.; Chandler B.; Turnbull A.; Quinn A.; Finch C.; Holl C.; Cooper J.; Evans A.; Khaliq W.; Collins A.; Gude E.T.; Love N.; van Koutrik L.; Hunt J.; Kaye D.; Fisher E.; Brayne A.; Tuckey V.; Jackson P.; Parkin J.; Brealey D.; Raith E.; Tariq A.; Houlden H.; Tucci A.; Hardy J.; Moncur E.; Highgate J.; Cowley A.; Mitra A.; Stead R.; Behan T.; Burnett C.; Newton M.; Heeney E.; Pollard R.; Hatton J.; Patel A.; Kasipandian V.; Allibone S.; Genetu R.M.; Otahal I.; O'Brien L.; Omar Z.; Perkins E.; Davies K.; Tetla D.; Pothecary C.; Deacon B.; Shelley B.; Irvine V.; Williams S.; Williams P.; Birch J.; Goodsell J.; Tutton R.; Bough L.; Winter-Goodwin B.; Kitson R.; Pinnell J.; Wilson A.; Nortcliffe T.; Wood T.; Home M.; Holdroyd K.; Robinson M.; Hanson K.; Shaw R.; Greig J.; Brady M.; Haigh A.; Matupe L.; Usher M.; Mellor S.; Dale S.; Gledhill L.; Shaw L.; Turner G.; Kelly D.; Anwar B.; Riley H.; Sturgeon H.; Ali A.; Thomis L.; Melia D.; Dance A.; Humphreys S.; Frost I.; Gopal V.; Godden J.; Holden A.; Swann S.; Smith T.; Clapham M.; Poultney U.; 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de Silva T.; Sigfrid L.; Solomon T.; Sriskandan S.; Stuart D.; Tedder R.S.; Thomson E.C.; Thompson A.A.R.; Thwaites R.S.; Turtle L.C.W.; Zambon M.; Hardwick H.; Donohue C.; Lyons R.; Norman L.; Pius R.; Drake T.M.; Fairfield C.J.; Knight S.R.; Mclean K.A.; Murphy D.; Shaw C.A.; Dalton J.; Girvan M.; Saviciute E.; Roberts S.; Harrison J.; Marsh L.; Connor M.; Halpin S.; Jackson C.; Gamble C.; Leeming G.; Wham M.; Greenhalf W.; Shaw V.; McDonald S.; Keating S.; Ganna A.; Sulem P.; van Heel D.A.; Cordioli M.; Sveinbjornsson G.; Niemi M.E.K.; Shelton J.F.; Shastri A.J.; Ye C.; Weldon C.H.; Filshtein-Sonmez T.; Coker D.; Symons A.; Esparza-Gordillo J.; Aslibekyan S.; Auton A.; Krieger J.E.; Marques E.; Jannes C.E.; Mari F.; Daga S.; Baldassarri M.; Benetti E.; Furini S.; Fallerini C.; Fava F.; Valentino F.; Doddato G.; Giliberti A.; Tita R.; Amitrano S.; Bruttini M.; Croci S.; Meloni I.; Pinto A.M.; Frullanti E.; Mencarelli M.A.; Rizzo C.L.; Montagnani F.; Di Sarno L.; Tommasi A.; Palmieri M.; Emiliozzi A.; Fabbiani M.; Rossetti B.; Zanelli G.; Bargagli E.; Bergantini L.; D'Alessandro M.; Cameli P.; Bennet D.; Anedda F.; Marcantonio S.; Scolletta S.; Franchi F.; Mazzei M.A.; Guerrini S.; Conticini E.; Cantarini L.; Frediani B.; Tacconi D.; Spertilli C.; Feri M.; Donati A.; Scala R.; Guidelli L.; Spargi G.; Corridi M.; Nencioni C.; Croci L.; Caldarelli G.P.; Spagnesi M.; Piacentini P.; Bandini M.; Desanctis E.; Cappelli S.; Canaccini A.; Verzuri A.; Anemoli V.; Ognibene A.; Vaghi M.; D'Arminio Monforte A.; Merlini E.; Mondelli M.U.; Mantovani S.; Ludovisi S.; Girardis M.; Venturelli S.; Sita M.; Cossarizza A.; Antinori A.; Vergori A.; Rusconi S.; Siano M.; Gabrieli A.; Riva A.; Francisci D.; Schiaroli E.; Scotton P.G.; Andretta F.; Panese S.; Scaggiante R.; Gatti F.; Parisi S.G.; Castelli F.; Quiros-Roldan M.E.; Magro P.; Zanella I.; Della Monica M.; Piscopo C.; Capasso M.; Russo R.; Andolfo I.; Iolascon A.; Fiorentino G.; Carella M.; Castori M.; Merla G.; Aucella F.; Raggi P.; Marciano C.; Perna R.; Bassetti M.; Di Biagio A.; Sanguinetti M.; Masucci L.; Valente S.; Mandala M.; Giorli A.; Salerni L.; Zucchi P.; Parravicini P.; Menatti E.; Baratti S.; Trotta T.; Giannattasio F.; Coiro G.; Lena F.; Coviello D.A.; Mussini C.; Bosio G.; Martinelli E.; Mancarella S.; Tavecchia L.; Crotti L.; Picchiotti N.; Gori M.; Gabbi C.; Sanarico M.; Ceri S.; Pinoli P.; Raimondi F.; Biscarini F.; Stella A.; Shen X.; Ponting C.P.; Fawkes A.; Tenesa A.; Caulfield M.; Scott R.; Rowan K.; Murphy L.; Openshaw P.J.M.; Semple M.G.; Law A.; Vitart V.; Wilson J.F.; Baillie J.K./titolo:Genetic mechanisms of critical illness in COVID-19/doi:10.1038%2Fs41586-020-03065-y/rivista:Nature (Lond.)/anno:2021/pagina_da:92/pagina_a:98/intervallo_pagine:92–98/volume:591
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Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6867dddecc656504bcaf6d92c773daa

Trans-ethnic analysis reveals genetic and non-genetic associations with COVID-19 susceptibility and severity

Autor: Jorge Esparza-Gordillo, Catherine H. Weldon, Stella Aslibekyan, Teresa Filshtein-Somnez, Janie F. Shelton, Chelsea Ye, Antony Symons, Adam Auton, Anjali J. Shastri, Daniella Coker

COVID-19 presents with a wide range of severity, from asymptomatic in some individuals to fatal in others. Based on a study of over one million 23andMe research participants, we report genetic and non-genetic associations with testing positive for CO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55b50ba112843fcb587051abe6925952
https://doi.org/10.1101/2020.09.04.20188318

Differential Roles for Interleukin-23 and Interleukin-17 in Intestinal Immunoregulation

Autor: John A. Davis, Yu Zhang, James B. Rottman, Fergus R. Byrne, Jeannette Bigler, Alison L. Budelsky, Carole L. Smith, Antony Symons, Mike Fiorino, William A. Brown, Erin Stevens, Joseph R. Maxwell, Jennifer E. Towne

Publikováno v: Immunity. 43(4):739-750

SummaryInterleukin-23 (IL-23) and IL-17 are cytokines currently being targeted in clinical trials. Although inhibition of both of these cytokines is effective for treating psoriasis, IL-12 and IL-23 p40 inhibition attenuates Crohn’s disease, wherea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c5b9dc146ce130e7b12a123c458cd9f