Blood transcriptomic discrimination of bacterial and viral infections in the emergency department: a multi-cohort observational validation study

Autor: Dayle Sampson, Thomas D. Yager, Brian Fox, Laura Shallcross, Leo McHugh, Therese Seldon, Antony Rapisarda, Richard B. Brandon, Krupa Navalkar, Nandi Simpson, Sian Stafford, Eliza Gil, Cristina Venturini, Evi Tsaliki, Jennifer Roe, Benjamin Chain, Mahdad Noursadeghi

Publikováno v: BMC Medicine, Vol 18, Iss 1, Pp 1-12 (2020)

Abstract Background There is an urgent need to develop biomarkers that stratify risk of bacterial infection in order to support antimicrobial stewardship in emergency hospital admissions. Methods We used computational machine learning to derive a rul

Externí odkaz: https://doaj.org/article/f49351239a2f427ab2056944955526c8

Correction to: Blood transcriptomic discrimination of bacterial and viral infections in the emergency department: a multi-cohort observational validation study

Autor: Dayle Sampson, Thomas D. Yager, Brian Fox, Laura Shallcross, Leo McHugh, Therese Seldon, Antony Rapisarda, Roslyn A. Hendriks, Richard B. Brandon, Krupa Navalkar, Nandi Simpson, Sian Stafford, Eliza Gil, Cristina Venturini, Evi Tsaliki, Jennifer Roe, Benjamin Chain, Mahdad Noursadeghi

Publikováno v: BMC Medicine, Vol 18, Iss 1, Pp 1-1 (2020)

An amendment to this paper has been published and can be accessed via the original article.

Externí odkaz: https://doaj.org/article/d740ed64c3ac49a68c827986110142dc

Hip and Knee Section, Treatment, Algorithm: Proceedings of International Consensus on Orthopedic Infections

Autor: N.J. In den Kleef, Dirk Jan F Moojen, Brianna Fram, Marc W. Nijhof, Antony Rapisarda, Salvador Rivero-Boschert, Tae Kyun Kim, Ali Oliashirazi, Rudolf W. Poolman, James J. Purtill, Ewout S Veltman, Thanainit Chotanaphuti, Sébastien Lustig, Paul M. Courtney, Feng-Chih Kuo

Publikováno v: The Journal of Arthroplasty. 34:S393-S397

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcb4e5aeb00bb2ca38f9001f4411853d
https://doi.org/10.1016/j.arth.2018.09.024

Physician agreement on the diagnosis of sepsis in the intensive care unit: estimation of concordance and analysis of underlying factors in a multicenter cohort

Autor: Antony Rapisarda, Adey Tsegaye, Jorge P. Parada, Thomas D. Yager, Jordan A. Kempker, Robert A. Balk, Gourang P. Patel, Paul H. Mayo, Greg S. Martin, Venkataramana K. Sidhaye, Steven M. Opal, Therese Seldon, Russell R. Miller, Stella Hahn, Roslyn A. Brandon, Richard E. Rothman, Mangala Narasimhan, Dayle Sampson, Annette M. Esper, Franco R. D'Alessio, Majid Afshar, Mark Yoder, Richard Bruce Brandon, John P. Burke, Emily R. Gilbert, Leo McHugh, Jared A. Greenberg, Mitchell M. Levy, Bert K. Lopansri

Publikováno v: Journal of Intensive Care
Journal of Intensive Care, Vol 7, Iss 1, Pp 1-17 (2019)

Background Differentiating sepsis from the systemic inflammatory response syndrome (SIRS) in critical care patients is challenging, especially before serious organ damage is evident, and with variable clinical presentations of patients and variable t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63f075b8cf4fff92c339eebd564b0e7
https://doi.org/10.1186/s40560-019-0368-2

A Molecular Host Response Assay to Discriminate Between Sepsis and Infection-Negative Systemic Inflammation in Critically Ill Patients : Discovery and Validation in Independent Cohorts

Autor: James T. Kirk, Marc J. M. Bonten, Antony Rapisarda, Tom van der Poll, Mervyn Thomas, Brendon P. Scicluna, Leo McHugh, Richard Bruce Brandon, Olaf L. Cremer, Marcus J. Schultz, Jeffrey Lipman, Jeffrey J. Presneill, Thomas D. Yager, Lonneke A. van Vught, Peter M. C. Klein Klouwenberg, Deon J. Venter, A Sutherland, Therese Seldon, Roslyn A. Brandon

Publikováno v: PLoS medicine, 12(12). Public Library of Science
PLoS Medicine, Vol 12, Iss 12, p e1001916 (2015)
PLoS Medicine
PLoS Medicine, 12(12), e1001916. Public Library of Science

Background: Systemic inflammation is a whole body reaction having an infection-positive (i.e., sepsis) or infection-negative origin. It is important to distinguish between these two etiologies early and accurately because this has significant therape

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1df1b69e8ea0e9d0a628471368d67d8
https://dspace.library.uu.nl/handle/1874/333500