Localization signals within ataxin-3 influence the formation of intranuclear aggregates in spinocerebellar ataxia type 3

Autor: Antony, PMA, Boy, J, Henderson, B, Stamminger, T, Rieß, O, Schmidt, T

Publikováno v: Aktuelle Neurologie; 20240101, Issue: Preprints

PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation.

Autor: Lind-Holm Mogensen F; Neuro-Immunology Group, Department of Cancer Research, Luxembourg Institute of Health, 6A, rue Nicolas-Ernest Barblé, L-1210, Luxembourg, Luxembourg.; Faculty of Science, Technology and Medicine, University of Luxembourg, L-4365, Esch-sur-Alzette, Luxembourg., Sousa C; Neuro-Immunology Group, Department of Cancer Research, Luxembourg Institute of Health, 6A, rue Nicolas-Ernest Barblé, L-1210, Luxembourg, Luxembourg.; International Iberian Nanotechnology Laboratory, 4715-330, Braga, Portugal., Ameli C; Integrative Cell Signalling Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, L-4362, Esch-sur-Alzette, Luxembourg., Badanjak K; Molecular and Functional Neurobiology Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, L-4362, Esch-sur-Alzette, Luxembourg., Pereira SL; Molecular and Functional Neurobiology Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, L-4362, Esch-sur-Alzette, Luxembourg., Muller A; Bioinformatics Platform, Department of Medical Informatics, Luxembourg Institute of Health, L-1445, Strassen, Luxembourg.; LuxGen Genome Center, Luxembourg Institute of Health and Laboratoire National de Santé, L-3555, Dudelange, Luxembourg., Kaoma T; Bioinformatics Platform, Department of Medical Informatics, Luxembourg Institute of Health, L-1445, Strassen, Luxembourg., Coowar D; Rodent Platform, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, L-4362, Esch-sur-Alzette, Luxembourg., Scafidi A; Neuro-Immunology Group, Department of Cancer Research, Luxembourg Institute of Health, 6A, rue Nicolas-Ernest Barblé, L-1210, Luxembourg, Luxembourg.; Faculty of Science, Technology and Medicine, University of Luxembourg, L-4365, Esch-sur-Alzette, Luxembourg., Poovathingal SK; Integrative Cell Signalling Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, L-4362, Esch-sur-Alzette, Luxembourg.; Single Cell Analytics and Microfluidics Core, Vlaams Instituut Voor Biotechnologie-KU Leuven, 3000, Louvain, Belgium., Tziortziou M; Molecular and Functional Neurobiology Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, L-4362, Esch-sur-Alzette, Luxembourg., Antony PMA; Bioimaging Platform, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, L-4362, Esch-sur-Alzette, Luxembourg., Nicot N; LuxGen Genome Center, Luxembourg Institute of Health and Laboratoire National de Santé, L-3555, Dudelange, Luxembourg., Ginolhac A; Department of Life Sciences and Medicine, Faculty of Science, Technology and Medicine, University of Luxembourg, L-4365, Esch-sur-Alzette, Luxembourg., Vogt Weisenhorn DM; Institute of Developmental Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764, Neuherberg, Germany.; Technische Universität München-Weihenstephan, 85354, Freising, Germany., Wurst W; Institute of Developmental Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764, Neuherberg, Germany.; Technische Universität München-Weihenstephan, 85354, Freising, Germany.; German Center for Neurodegenerative Diseases (DZNE), 81377, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), 81377, Munich, Germany.; Deutsche Zentrum für Psychische Gesundheit (DZPG), 80336, Munich, Germany., Poli A; Neuro-Immunology Group, Department of Cancer Research, Luxembourg Institute of Health, 6A, rue Nicolas-Ernest Barblé, L-1210, Luxembourg, Luxembourg., Nazarov PV; Bioinformatics Platform, Department of Medical Informatics, Luxembourg Institute of Health, L-1445, Strassen, Luxembourg.; Multiomics Data Science Group, Department of Cancer Research, Luxembourg Institute of Health, L-1445, Strassen, Luxembourg., Skupin A; Integrative Cell Signalling Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, L-4362, Esch-sur-Alzette, Luxembourg.; Department of Neuroscience, University of California San Diego, La Jolla, CA, 92093, USA.; Integrative Biophysics, Department of Physics and Material Science, University of Luxembourg, L-1511, Luxembourg, Luxembourg., Grünewald A; Molecular and Functional Neurobiology Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, L-4362, Esch-sur-Alzette, Luxembourg.; Institute of Neurogenetics, University of Lübeck, 23538, Lübeck, Germany., Michelucci A; Neuro-Immunology Group, Department of Cancer Research, Luxembourg Institute of Health, 6A, rue Nicolas-Ernest Barblé, L-1210, Luxembourg, Luxembourg. alessandro.michelucci@lih.lu.

Publikováno v: Journal of neuroinflammation [J Neuroinflammation] 2024 Jul 16; Vol. 21 (1), pp. 174. Date of Electronic Publication: 2024 Jul 16.

Parkinson's Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2-Hydroxypropyl-β-Cyclodextrin Treatment.

Autor: Jarazo J; Developmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine University of Luxembourg, Esch-sur-Alzette, Luxembourg.; OrganoTherapeutics société à responsabilité limitée simplifiée (SARL-S), Esch-sur-Alzette, Luxembourg., Barmpa K; Developmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine University of Luxembourg, Esch-sur-Alzette, Luxembourg., Modamio J; Developmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine University of Luxembourg, Esch-sur-Alzette, Luxembourg., Saraiva C; Developmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine University of Luxembourg, Esch-sur-Alzette, Luxembourg., Sabaté-Soler S; Developmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine University of Luxembourg, Esch-sur-Alzette, Luxembourg., Rosety I; Developmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine University of Luxembourg, Esch-sur-Alzette, Luxembourg., Griesbeck A; Sciomics GmbH, Heidelberg, Germany., Skwirblies F; Sciomics GmbH, Heidelberg, Germany., Zaffaroni G; Institute for Globally Distributed Open Research and Education, Gothenburg, Sweden., Smits LM; Developmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine University of Luxembourg, Esch-sur-Alzette, Luxembourg., Su J; Institute of Health Sciences, China Medical University, Shenyang, China., Arias-Fuenzalida J; Developmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine University of Luxembourg, Esch-sur-Alzette, Luxembourg., Walter J; Developmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine University of Luxembourg, Esch-sur-Alzette, Luxembourg., Gomez-Giro G; Developmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine University of Luxembourg, Esch-sur-Alzette, Luxembourg., Monzel AS; Developmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine University of Luxembourg, Esch-sur-Alzette, Luxembourg., Qing X; Developmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine University of Luxembourg, Esch-sur-Alzette, Luxembourg., Vitali A; Translational Neuroscience, Luxembourg Centre for Systems Biomedicine University of Luxembourg, Esch-sur-Alzette, Luxembourg., Cruciani G; Translational Neuroscience, Luxembourg Centre for Systems Biomedicine University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Disease Modeling and Screening Platform, Luxembourg Institute of Systems Biomedicine, University of Luxembourg and Luxembourg Institute of Health, Belvaux, Luxembourg., Boussaad I; Translational Neuroscience, Luxembourg Centre for Systems Biomedicine University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Disease Modeling and Screening Platform, Luxembourg Institute of Systems Biomedicine, University of Luxembourg and Luxembourg Institute of Health, Belvaux, Luxembourg., Brunelli F; Department of Molecular Medicine, University of Pavia, Pavia, Italy., Jäger C; Metabolomics Platform, Enzymology and Metabolism, Luxembourg Centre for Systems Biomedicine University of Luxembourg, Esch-sur-Alzette, Luxembourg., Rakovic A; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany., Li W; Institute of Health Sciences, China Medical University, Shenyang, China., Yuan L; Institute of Health Sciences, China Medical University, Shenyang, China., Berger E; Developmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine University of Luxembourg, Esch-sur-Alzette, Luxembourg., Arena G; Translational Neuroscience, Luxembourg Centre for Systems Biomedicine University of Luxembourg, Esch-sur-Alzette, Luxembourg., Bolognin S; Developmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine University of Luxembourg, Esch-sur-Alzette, Luxembourg., Schmidt R; Sciomics GmbH, Heidelberg, Germany., Schröder C; Sciomics GmbH, Heidelberg, Germany., Antony PMA; Translational Neuroscience, Luxembourg Centre for Systems Biomedicine University of Luxembourg, Esch-sur-Alzette, Luxembourg., Klein C; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany., Krüger R; Translational Neuroscience, Luxembourg Centre for Systems Biomedicine University of Luxembourg, Esch-sur-Alzette, Luxembourg.; Centre Hospitalier de Luxembourg, Parkinson Research Clinic, Luxembourg, Luxembourg.; Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg., Seibler P; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany., Schwamborn JC; Developmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine University of Luxembourg, Esch-sur-Alzette, Luxembourg.

Publikováno v: Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2022 Jan; Vol. 37 (1), pp. 80-94. Date of Electronic Publication: 2021 Oct 12.

The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1.

Autor: Walter J; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Belvaux, Luxembourg., Bolognin S; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Belvaux, Luxembourg., Poovathingal SK; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Belvaux, Luxembourg., Magni S; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Belvaux, Luxembourg., Gérard D; Department of Life Science and Medicine (DLSM), University of Luxembourg, 4362 Belvaux, Luxembourg., Antony PMA; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Belvaux, Luxembourg., Nickels SL; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Belvaux, Luxembourg; Department of Life Science and Medicine (DLSM), University of Luxembourg, 4362 Belvaux, Luxembourg., Salamanca L; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Belvaux, Luxembourg., Berger E; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Belvaux, Luxembourg., Smits LM; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Belvaux, Luxembourg., Grzyb K; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Belvaux, Luxembourg., Perfeito R; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga, Coimbra 3004-504, Portugal., Hoel F; Department of Biomedicine, University of Bergen, Jonas Lies Vei 91, 5009 Bergen, Norway., Qing X; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Belvaux, Luxembourg., Ohnmacht J; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Belvaux, Luxembourg; Department of Life Science and Medicine (DLSM), University of Luxembourg, 4362 Belvaux, Luxembourg., Bertacchi M; Université Côte d'Azur, CNRS, Inserm, 06108 Nice, France., Jarazo J; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Belvaux, Luxembourg., Ignac T; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Belvaux, Luxembourg., Monzel AS; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Belvaux, Luxembourg., Gonzalez-Cano L; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Belvaux, Luxembourg., Krüger R; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Belvaux, Luxembourg; Transversal Translational Medicine, Luxembourg Institute of Health, Strassen, Luxembourg; Centre Hospitalier de Luxembourg, Luxembourg City, Luxembourg., Sauter T; Department of Life Science and Medicine (DLSM), University of Luxembourg, 4362 Belvaux, Luxembourg., Studer M; Université Côte d'Azur, CNRS, Inserm, 06108 Nice, France., de Almeida LP; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga, Coimbra 3004-504, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra 3000-548, Portugal., Tronstad KJ; Department of Biomedicine, University of Bergen, Jonas Lies Vei 91, 5009 Bergen, Norway., Sinkkonen L; Department of Life Science and Medicine (DLSM), University of Luxembourg, 4362 Belvaux, Luxembourg., Skupin A; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Belvaux, Luxembourg; Center for Research of Biological Systems, University of California, San Diego, La Jolla, CA 92093, USA., Schwamborn JC; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Belvaux, Luxembourg. Electronic address: jens.schwamborn@uni.lu.

Publikováno v: Cell reports [Cell Rep] 2021 Oct 19; Vol. 37 (3), pp. 109864.

Fibroblast mitochondria in idiopathic Parkinson's disease display morphological changes and enhanced resistance to depolarization.

Autor: Antony PMA; LCSB, University of Luxembourg, Belvaux, Luxembourg. paul.antony@uni.lu., Kondratyeva O; LCSB, University of Luxembourg, Belvaux, Luxembourg., Mommaerts K; IBBL, Luxembourg, Luxembourg., Ostaszewski M; LCSB, University of Luxembourg, Belvaux, Luxembourg., Sokolowska K; IBBL, Luxembourg, Luxembourg., Baumuratov AS; LCSB, University of Luxembourg, Belvaux, Luxembourg., Longhino L; CHL, Luxembourg, Luxembourg., Poulain JF; CHL, Luxembourg, Luxembourg., Grossmann D; LCSB, University of Luxembourg, Belvaux, Luxembourg., Balling R; LCSB, University of Luxembourg, Belvaux, Luxembourg., Krüger R; LCSB, University of Luxembourg, Belvaux, Luxembourg.; CHL, Luxembourg, Luxembourg.; Transversal Translational Medicine, Luxembourg Institute of Health (LIH), Strassen, Luxembourg., Diederich NJ; CHL, Luxembourg, Luxembourg.

Publikováno v: Scientific reports [Sci Rep] 2020 Jan 31; Vol. 10 (1), pp. 1569. Date of Electronic Publication: 2020 Jan 31.