Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Antony P. Jackson"'
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-24 (2024)
Abstract Voltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of cancers, derived from “non-excitable” tissues that do no
Externí odkaz:
https://doaj.org/article/27ffa265831142f6b7a441d2795d3526
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Cardiac arrhythmias cause significant morbidity and mortality and pose a major public health problem. They arise from disruptions in the normally orderly propagation of cardiac electrophysiological activation and recovery through successive cardiomyo
Externí odkaz:
https://doaj.org/article/5931e0cf47424e51a948af6be9c4a03b
Autor:
Joshua A. Morris, Oliver J. Bardsley, Samantha C. Salvage, Antony P. Jackson, Hugh R. Matthews, Christopher L-H. Huang
Publikováno v:
Frontiers in Physiology, Vol 14 (2024)
Introduction: In addition to gap junction conduction, recent reports implicate possible ephaptic coupling contributions to action potential (AP) propagation between successive adjacent cardiomyocytes. Here, AP generation in an active cell, withdraws
Externí odkaz:
https://doaj.org/article/c07da66d15954f158d1d4733b176bd69
Autor:
Christopher A. Beaudoin, Samir W. Hamaia, Christopher L.-H. Huang, Tom L. Blundell, Antony P. Jackson
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
The RGD motif in the Severe Acute Syndrome Coronavirus 2 (SARS-CoV-2) spike protein has been predicted to bind RGD-recognizing integrins. Recent studies have shown that the spike protein does, indeed, interact with αVβ3 and α5β1 integrins, both o
Externí odkaz:
https://doaj.org/article/6232723385df46bc893a5afb2e3780ce
Publikováno v:
Biomolecules, Vol 10, Iss 7, p 989 (2020)
Voltage-gated sodium (Nav) channels drive the rising phase of the action potential, essential for electrical signalling in nerves and muscles. The Nav channel α-subunit contains the ion-selective pore. In the cardiomyocyte, Nav1.5 is the main Nav ch
Externí odkaz:
https://doaj.org/article/fafd0964380941c4a1fb3e0019896b5e
Publikováno v:
Data in Brief, Vol 3, Iss C, Pp 29-33 (2015)
In developing a new quantitative AP-MS method for exploring interactomes in the chicken B-cell line DT40, we also surveyed the most abundant proteins in this organism and explored the likely contaminants that bind to a variety of affinity resins that
Externí odkaz:
https://doaj.org/article/b5c3ec7f21d040ffa678ad316b28dce2
Autor:
Sivakumar Namadurai, Nikitha R. Yereddi, Fiona S. Cusdin, Christopher L.-H. Huang, Dimitri Y. Chirgadze, Antony P. Jackson
Publikováno v:
Open Biology, Vol 5, Iss 1 (2015)
Voltage-gated sodium (Nav) channels are intrinsic plasma membrane proteins that initiate the action potential in electrically excitable cells. They are a major focus of research in neurobiology, structural biology, membrane biology and pharmacology.
Externí odkaz:
https://doaj.org/article/257996248ebd40c38a40c05259dbe702
Autor:
Christopher A. Beaudoin, Emmanouela Petsolari, Samir W. Hamaia, Sharif Hala, Fadwa S. Alofi, Arun P. Pandurangan, Tom L. Blundell, Sundeep Chaitanya Vedithi, Christopher L.-H. Huang, Antony P. Jackson
Publikováno v:
Biochemical and Biophysical Research Communications. 666:61-67
The RGD motif on the SARS-CoV-2 spike protein has been suggested to interact with RGD-binding integrins αVβ3 and α5β1 to enhance viral cell entry and alter downstream signaling cascades. The D405N mutation on the Omicron subvariant spike proteins
Autor:
Samantha C. Salvage, Angela F. Dulhunty, Kamalan Jeevaratnam, Antony P. Jackson, Christopher L.-H. Huang
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 378
Skeletal and cardiac muscle excitation–contraction coupling commences with Na v 1.4/Na v 1.5-mediated, surface and transverse (T-) tubular, action potential generation. This initiates feedforward , allosteric or Ca 2+ -mediated, T-sarcoplasmic reti
Autor:
Samantha C. Salvage, Taufiq Rahman, David A. Eagles, Johanna S. Rees, Glenn F. King, Christopher L‐H. Huang, Antony P. Jackson
Publikováno v:
Journal of Cellular Physiology.