Zobrazeno 1 - 10
of 225
pro vyhledávání: '"Antony M, Carr"'
Autor:
Eri Koyanagi, Yoko Kakimoto, Tamiko Minamisawa, Fumiya Yoshifuji, Toyoaki Natsume, Atsushi Higashitani, Tomoo Ogi, Antony M. Carr, Masato T. Kanemaki, Yasukazu Daigaku
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Profiling of human DNA polymerase Polε and Polα demonstrates their roles in leading and lagging strand DNA synthesis, and their independent measures allowed accurate predictions of replication dynamics and effects of transcription.
Externí odkaz:
https://doaj.org/article/107ddf542bee417bbce94543b2172205
Autor:
Alice M Budden, Murat Eravci, Adam T Watson, Eduard Campillo-Funollet, Antony W Oliver, Karel Naiman, Antony M Carr
Publikováno v:
eLife, Vol 12 (2023)
Arrested replication forks, when restarted by homologous recombination, result in error-prone DNA syntheses and non-allelic homologous recombination. Fission yeast RTS1 is a model fork barrier used to probe mechanisms of recombination-dependent resta
Externí odkaz:
https://doaj.org/article/823a7db80f5f4850904e186ae21c686d
Autor:
Mélina Vaurs, Karel Naiman, Chaïnez Bouabboune, Sudhir Rai, Katarzyna Ptasińska, Marion Rives, Samah Matmati, Antony M. Carr, Vincent Géli, Stéphane Coulon
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112537- (2023)
Summary: Efficient replication of terminal DNA is crucial to maintain telomere stability. In fission yeast, Taz1 and the Stn1-Ten1 (ST) complex play prominent roles in DNA-ends replication. However, their function remains elusive. Here, we have analy
Externí odkaz:
https://doaj.org/article/6edcf68cf0b44f51bdedcda436c81243
Autor:
Zizhi Tang, Ming Zeng, Xiaojun Wang, Chang Guo, Peng Yue, Xiaohu Zhang, Huiqiang Lou, Jun Chen, Dezhi Mu, Daochun Kong, Antony M. Carr, Cong Liu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The authors uncover synthetic lethality between TP53 and ENDOD1, which contains an atypical endonuclease domain. Co-depleted G1 cells accumulate single stranded DNA and die. Combined with xenograft data the work identifies ENDOD1 as a potential cance
Externí odkaz:
https://doaj.org/article/6635eea4132e4bd4861d24a3f717f185
Publikováno v:
Wellcome Open Research, Vol 7 (2022)
Single-molecule localisation microscopy (SMLM) uses software to extract super-resolved positions from microscope images of fluorescent molecules. These localisations can then be used to render super-resolution images or analysed to extract informatio
Externí odkaz:
https://doaj.org/article/688d81851bd94264a8f53210aa52b069
Autor:
Freddy Khayat, Elda Cannavo, Majedh Alshmery, William R. Foster, Charly Chahwan, Martino Maddalena, Christopher Smith, Antony W. Oliver, Adam T. Watson, Antony M. Carr, Petr Cejka, Alessandro Bianchi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Telomeres suppress the DNA damage response at chromosome ends. Here the authors show that in budding yeast the activity of the MRX complex in DNA repair and DNA damage signaling is inhibited by telomeric protein Rif2 via a short motif at the N-termin
Externí odkaz:
https://doaj.org/article/8cecf44805f740329669d3853d59d8f7
Autor:
Karel Naiman, Eduard Campillo-Funollet, Adam T. Watson, Alice Budden, Izumi Miyabe, Antony M. Carr
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Replication forks that are stalled at obstacles on the DNA template can be restarted by homologous recombination. Here, the authors show replication dynamics during homologous recombination-dependent replication fork restart by combining polymerase u
Externí odkaz:
https://doaj.org/article/2a6dc8952f774e83b7e96e8950dd7e83
Autor:
Maria B. Goncalves, Julien Moehlin, Earl Clarke, John Grist, Carl Hobbs, Antony M. Carr, Julian Jack, Marco Antonio Mendoza-Parra, Jonathan P.T. Corcoran
Publikováno v:
iScience, Vol 20, Iss , Pp 554-566 (2019)
Summary: Neuropathic pain (NP) is associated with profound gene expression alterations within the nociceptive system. DNA mechanisms, such as epigenetic remodeling and repair pathways have been implicated in NP. Here we have used a rat model of perip
Externí odkaz:
https://doaj.org/article/8551eb581aa8412dbb09b8e31da54c5a
Autor:
Róbert Zach, Antony M. Carr
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Background: In vitro experiments utilising the reconstituted Saccharomyces cerevisiae eukaryotic replisome indicated that the efficiency of the leading strand replication is impaired by a moderate increase in Polδ concentration. It was hypothesised
Externí odkaz:
https://doaj.org/article/25e2c150cc7246a9b3a9ee670ca46a9a
Autor:
Thomas J Etheridge, Desiree Villahermosa, Eduard Campillo-Funollet, Alex David Herbert, Anja Irmisch, Adam T Watson, Hung Q Dang, Mark A Osborne, Antony W Oliver, Antony M Carr, Johanne M Murray
Publikováno v:
eLife, Vol 10 (2021)
The essential Smc5/6 complex is required in response to replication stress and is best known for ensuring the fidelity of homologous recombination. Using single-molecule tracking in live fission yeast to investigate Smc5/6 chromatin association, we s
Externí odkaz:
https://doaj.org/article/a87f3e7fa1b34575930f08ff8d91c899