Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Antony D. Buss"'
Publikováno v:
CHIMIA, Vol 61, Iss 6 (2007)
The screening of crude natural product extracts can be problematic, especially in enzyme/protein-based assays, due to promiscuous inhibitors and interference compounds, while high salt and lipid content can significantly dilute compounds of interest.
Externí odkaz:
https://doaj.org/article/862d02f6c6b74ebcbc361cead15578a9
Autor:
Mark S. Butler, Siewbee Ng, K. Yoganathan, Shugeng Cao, Antony D. Buss, Srinivasulu Aitipamula, Stephen R. Whitton, Sharon C. Crasta
Publikováno v:
Tetrahedron. 64:10181-10187
Bioassay-guided isolation using an MRSA whole cell assay yielded four novel benzophenone dimers, microsphaerins A-D (1-4), from two Singapore isolates of the soil anamorph Microsphaeropsis sp. The structures of 1-4 were elucidated on the basis of spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab595e21f0497fb24feaa9e1c23403a9
https://doi.org/10.1016/j.tet.2008.08.038
https://doi.org/10.1016/j.tet.2008.08.038
Autor:
Jung-Rae Rho, Hyukjae Choi, Eun-Hee Kim, Sok Peng Ng, K. Yoganathan, Gurusamy Subramaniam, Siewbee Ng, Mark S. Butler, William H. Gerwick, Antony D. Buss
Gargantulide A (1), an extremely complex 52-membered macrolactone, was isolated from Streptomyces sp. A42983 and displayed moderate activity against MRSA. The planar structure of 1 was determined using 2D NMR, and its stereochemistry was partially es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5bcf9fb6f5abc0ab2dcb733e1f1be17
https://europepmc.org/articles/PMC5125438/
https://europepmc.org/articles/PMC5125438/
Autor:
Antony D. Buss, Mark S. Butler
Publikováno v:
Biochemical Pharmacology. 71:919-929
Natural products have played a pivotal role in antibiotic drug discovery with most antibacterial drugs being derived from a natural product or natural product lead. However, the rapid onset of resistance to most antibacterial drugs diminishes their e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad42db997ff68f11070acb5b0f4cd743
https://doi.org/10.1016/j.bcp.2005.10.012
https://doi.org/10.1016/j.bcp.2005.10.012
Autor:
Shugeng Cao, Yicun Huang, and Antony D. Buss, K. Yoganathan, Christine Rossant, Siewbee Ng, Robert P. Glover, Jagadese J. Vittal, Mark S. Butler
Publikováno v:
Journal of Natural Products. 67:1681-1684
An extract from the fungus Emericella aurantiobrunnea was found to compete with macrophage inflammatory protein (MIP)-1alpha for binding to human CCR5 in a scintillation proximity assay (SPA). Bioassay-guided fractionation led to the isolation of var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5005f1fb00eb06a78e4c785c13194fd0
https://doi.org/10.1021/np049844c
https://doi.org/10.1021/np049844c
Autor:
Antony D. Buss, Mark S. Butler
Publikováno v:
Drug Development Research. 62:362-370
Although combinatorial chemistry technology has enabled large libraries of compounds to be screened for biological activity and synthetic modifications to be effected rapidly, the reality is that quality leads and development candidates for many drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9def9431f5a2065f354fbca4c49ecea3
https://doi.org/10.1002/ddr.10389
https://doi.org/10.1002/ddr.10389
Autor:
Antony D. Buss, Alex S. Y. Lee, Victor C. Yu, Doel D. Soejarto, Lay-Kien Yang, Shing Leng Chan, Mei Chin Lee, Mark S. Butler, Nai Yang Fu, Horst Flotow, Kuan Onn Tan
Publikováno v:
Journal of Biological Chemistry. 278:20453-20456
The identification of small molecule inhibitors of antiapoptotic Bcl-2 family members has opened up new therapeutic opportunities, while the vast diversity of chemical structures and biological activities of natural products are yet to be systematica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90ddcd7198a5f3d0d8998e17069c77e8
https://doi.org/10.1074/jbc.c300138200
https://doi.org/10.1074/jbc.c300138200
Publikováno v:
SLAS Discovery. 7:367-371
Despite decades of research, malaria remains the world's most deadly parasitic disease. New treatments with novel mechanisms of action are urgently needed. Plasmepsin II is an aspartyl protease that has been validated as an antimalarial therapeutic t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4927aaabdf21e5dcc39bd9cbacd789c
https://doi.org/10.1177/108705710200700409
https://doi.org/10.1177/108705710200700409
Autor:
Philip J. Sidebottom, R. F. Middleton, Tracy C. Kennedy, Antony D. Buss, Oonagh S. Kinsman, Michael J. Dawson, Graham Webb, Richard J. P. Cannell, Nicholas L. Taylor
Publikováno v:
Europe PubMed Central
The isolation and structure determination of 6 analogues of the fungal protein synthesis inhibitor GR135402, from Graphium putredinis, is described. The relative potencies of the compounds as protein synthesis inhibitors and as in vitro antifungal ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad341e9578dc38b9c1060f42a57bb1e0
https://doi.org/10.7164/antibiotics.51.1012
https://doi.org/10.7164/antibiotics.51.1012
Autor:
Kia-Ngee Low, Shugeng Cao, Sharon C. Crasta, and Antony D. Buss, Robert P. Glover, Siewbee Ng, Mark S. Butler
Publikováno v:
Journal of Natural Products. 69:707-709
Bioassay-directed fractionation using a glucocorticoid receptor assay led to the isolation of two new, weakly active polyprenylated acylphloroglucinol derivatives, sundaicumones A (1) and B (2), from the leaves of Calophyllum sundaicum collected in S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::969a4cf1af730f85c85958b5694d5742
https://doi.org/10.1021/np050528n
https://doi.org/10.1021/np050528n