Localization of the delta-like-1-binding site in human Notch-1 and its modulation by calcium affinity

Autor: Brian R. Champion, Penny A. Handford, Antony C. Willis, P. Anton van der Merwe, Jemima Cordle, Sophie Hambleton, Christina RedfieldZ, Martin Stacey

The Notch signaling pathway plays a key role in a myriad of cellular processes, including cell fate determination. Despite extensive study of the downstream consequences of receptor activation, very little molecular data are available for the initial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d003403330df1effabe41198d9b8bbd2
https://doi.org/10.1074/jbc.m708424200

Order within a mosaic distribution of mitochondrial c-type cytochrome biogenesis systems?

Autor: Antony C. Willis, James W. A. Allen, Daniel J. Rigden, Stuart J. Ferguson, Michael L. Ginger, Andrew P. Jackson

Publikováno v: FEBS Journal. 275:2385-2402

Mitochondrial cytochromes c and c(1) are present in all eukaryotes that use oxygen as the terminal electron acceptor in the respiratory chain. Maturation of c-type cytochromes requires covalent attachment of the heme cofactor to the protein, and ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d229ffb5960f1cdb3c4e3fc59ee3a96
https://doi.org/10.1111/j.1742-4658.2008.06380.x

Identification and removal of O-linked and non-covalently linked sugars from recombinant protein produced using Pichia pastoris

Autor: Catherine M. Radcliffe, A. Kristina Downing, Antony C. Willis, Joanne M. O'Leary, Pauline M. Rudd, Raymond A. Dwek

Publikováno v: Protein Expression and Purification. 38:217-227

The use of the methylotrophic yeast Pichia pastoris for large-scale recombinant production of proteins for therapeutic uses and/or biophysical characterisation has been gaining popularity. Here we describe the use of this organism for the production

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a00ed3f2973a6050983157421647fb
https://doi.org/10.1016/j.pep.2004.08.010

Cancer-associated Cleavage of Cytokeratin 8/18 Heterotypic Complexes Exposes a Neoepitope in Human Adenocarcinomas

Autor: Jens C. Jensenius, Karin Kejling, Henrik J. Ditzel, Merel C.M. Strik, Morten Larsen, Antony C. Willis, Ahmad Waseem

Publikováno v: Ditzel, H, Strik, M C M, Larsen, M K, Willis, A C, Waseem, A, Kejling, K & Jensenius, J C 2002, ' Cancer-associated cleavage of cytokeratin 8/18 heterotypic complexes exposes a neoepitope in human adenocarcinomas ' Journal of Biological Chemistry, vol. 277, no. 24, pp. 21712-22 . https://doi.org/10.1074/jbc.M202140200

The intermediate filament network in simple glandular epithelial cells predominantly consists of heterotypic complexes of cytokeratin 8 (K8) and cytokeratin 18 (K18). In contrast to other cytokeratins, K8 and K18 are persistently expressed during mal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::982f1376d420e76db48e3fed47bdd2fa
https://doi.org/10.1074/jbc.m202140200

Lymphoid/Neuronal Cell Surface OX2 Glycoprotein Recognizes a Novel Receptor on Macrophages Implicated in the Control of Their Function

Autor: Antony C. Willis, Robert M. Hoek, Gavin J. Wright, A N Barclay, M J Puklavec, Jonathon D. Sedgwick, Marion H. Brown

Publikováno v: Immunity. 13(2):233-242

The OX2 membrane glycoprotein (CD200) is expressed on a broad range of tissues including lymphoid cells, neurons, and endothelium. We report the characterization of an OX2 receptor (OX2R) that is a novel protein restricted to cells of the myeloid lin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b736381d516e8c018fc5872199195303