Zobrazeno 1 - 10 of 32 pro vyhledávání: '"Antony Bigot"'
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Visible-Light-Driven CarboxyLic Amine Protocol (CLAP) for the Synthesis of 2-Substituted Piperazines under Batch and Flow Conditions
Autor: Antony Bigot, Till Bousquet, Mathieu Sauthier, Robin Gueret, Lydie Pelinski, Vincent Ferey
Publikováno v: Organic Letters. 22:5157-5162
Piperazines are privileged scaffolds in medicinal chemistry. Disclosed herein is a visible-light-promoted decarboxylative annulation protocol between a glycine-based diamine and various aldehydes to access 2-aryl, 2-heteroaryl, as well as 2-alkyl pip
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c687be4b0dae43731fdec98e4f32517
https://doi.org/10.1021/acs.orglett.0c01759
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3
Total Synthesis of (+)-Oxo-tomaymycin
Autor: Francoise Benedetti, Marc-Antoine Perrin, Franck Chouteau, Sebastien Bosc, Antony Bigot, Nicolas Champion
Publikováno v: Organic Process Research & Development. 24:762-768
(+)-Oxo-tomaymycin, a naturally occurring substance of the pyrrolo-1,4-benzodiazepine family, was synthesized using a short and efficient route. The key construction of the seven-membered ring by a...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c5a19dad282a2333f7635cb6998c957
https://doi.org/10.1021/acs.oprd.0c00009
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5
Total Synthesis of Herbimycin A
Autor: Sophie Canova, Serge Mignani, Antony Bigot, Janine Cossy, Véronique Bellosta, Patrick Mailliet
Publikováno v: Organic Letters. 9:145-148
[structure: see text] Hsp90 has recently emerged as a promising biological target for treatment of cancer. Herbimycin A and other members of the benzoquinoid ansamycin class of natural products are known to inhibit Hsp90 activity. The total synthesis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021f833c913bf5607b14acbb61ed0e7f
https://doi.org/10.1021/ol062642i
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6
Rearrangement of Homoallylic Alcohols Induced by DAST
Autor: Véronique Bellosta, Janine Cossy, Antony Bigot, Serge Mignani, Sophie Canova
Publikováno v: Organic Letters. 8:2091-2094
[reaction: see text] Treatment of beta,gamma-unsaturated monoprotected 1,2-diols with diethylaminosulfur trifluoride (DAST) allows the stereoselective formation of beta,gamma-unsaturated aldehydes in good yields and with a good transfer of chirality.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9e32b8b23eb6f1354b2c5286d87ea3
https://doi.org/10.1021/ol060529m
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7
An efficient total synthesis of K-13, a non-competitive inhibitor of ACE I
Autor: Jieping Zhu, Antony Bigot, Michèle Bois-Choussy
Publikováno v: Tetrahedron Letters. 41:4573-4577
An efficient synthesis of K-13 (I), a non-competitive inhibitor of ACE I with an endo biaryl ether bond, is described. The key cycloetherification reaction of linear tripeptide II gave a 17-membered macrocycle in quant. yield. [on SciFinder (R)]
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60569be7523811459ab6bc3ed91b0a8f
https://doi.org/10.1016/s0040-4039(00)00695-x
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10
Total Synthesis of an Antitumor Agent RA-VII via an Efficient Preparation of Cycloisodityrosine
Autor: Antony Bigot, Jieping Zhu, Marie Elise Tran Huu Dau
Publikováno v: The Journal of Organic Chemistry. 64:6283-6296
Details of efficient syntheses of cycloisodityrosine I (R = OMe, R1 = H, R2 = R3= Me, R4 = H) and a concise total synthesis of RA-VII were described. An intramol. SNAr-based cycloetherification reaction was employed as the key ring-closure step for c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d301a5ecabeca967ca17bc463b3ba9
https://doi.org/10.1021/jo990432w
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